The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-05

AUTHORS

M Rozakis-Adcock, R Fernley, J Wade, T Pawson, D Bowtell

ABSTRACT

Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggesting that these tyrosine kinases may activate a guanine-nucleotide releasing protein (GNRP). In Caenorhabditis elegans and Drosophila, genetic studies have shown that Ras activation by tyrosine kinases requires the protein Sem-5/drk, which contains a single Src-homology (SH) 2 domain and two flanking SH3 domains. Sem-5 is homologous to the mammalian protein Grb2, which binds the autophosphorylated EGF receptor and other phosphotyrosine-containing proteins such as Shc through its SH2 domain. Here we show that in rodent fibroblasts, the SH3 domains of Grb2 are bound to the proline-rich carboxy-terminal tail of mSos1, a protein homologous to Drosophila Sos. Sos is required for Ras signalling and contains a central domain related to known Ras-GNRPs. EGF stimulation induces binding of the Grb2-mSos1 complex to the autophosphorylated EGF receptor, and mSos1 phosphorylation. Grb2 therefore appears to link tyrosine kinases to a Ras-GNRP in mammalian cells. More... »

PAGES

83-85

Journal

TITLE

Nature

ISSUE

6424

VOLUME

363

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/363083a0

DOI

http://dx.doi.org/10.1038/363083a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022031225

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8479540


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3T3 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GRB2 Adaptor Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Son of Sevenless Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rozakis-Adcock", 
        "givenName": "M", 
        "id": "sg:person.01334671172.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334671172.10"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fernley", 
        "givenName": "R", 
        "id": "sg:person.0662770142.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662770142.28"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Wade", 
        "givenName": "J", 
        "id": "sg:person.01210702335.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210702335.33"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pawson", 
        "givenName": "T", 
        "id": "sg:person.01367636050.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367636050.26"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bowtell", 
        "givenName": "D", 
        "id": "sg:person.012102442677.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012102442677.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1126/science.1736363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002382243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90536-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002935937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90065-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004272509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.1.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005033955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(91)90339-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005460711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360762a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009718040", 
          "https://doi.org/10.1038/360762a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90169-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010009313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/363088a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012003451", 
          "https://doi.org/10.1038/363088a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/356340a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022331632", 
          "https://doi.org/10.1038/356340a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90167-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023123401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.4.1804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023784363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90075-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030097485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90170-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031295172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/320540a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040637908", 
          "https://doi.org/10.1038/320540a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360689a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042782556", 
          "https://doi.org/10.1038/360689a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.3.1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045896855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.5.2641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046843087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.3.1903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048963039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/313241a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052282285", 
          "https://doi.org/10.1038/313241a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/358351a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053445950", 
          "https://doi.org/10.1038/358351a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1280858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062471978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1379745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062478197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1496380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062486253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1604323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062494790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8438166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062655600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1991.tb08050.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078060028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078329566", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-05", 
    "datePublishedReg": "1993-05-01", 
    "description": "Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggesting that these tyrosine kinases may activate a guanine-nucleotide releasing protein (GNRP). In Caenorhabditis elegans and Drosophila, genetic studies have shown that Ras activation by tyrosine kinases requires the protein Sem-5/drk, which contains a single Src-homology (SH) 2 domain and two flanking SH3 domains. Sem-5 is homologous to the mammalian protein Grb2, which binds the autophosphorylated EGF receptor and other phosphotyrosine-containing proteins such as Shc through its SH2 domain. Here we show that in rodent fibroblasts, the SH3 domains of Grb2 are bound to the proline-rich carboxy-terminal tail of mSos1, a protein homologous to Drosophila Sos. Sos is required for Ras signalling and contains a central domain related to known Ras-GNRPs. EGF stimulation induces binding of the Grb2-mSos1 complex to the autophosphorylated EGF receptor, and mSos1 phosphorylation. Grb2 therefore appears to link tyrosine kinases to a Ras-GNRP in mammalian cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/363083a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6424", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "363"
      }
    ], 
    "name": "The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1", 
    "pagination": "83-85", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "68f662d42e2433936125caab7280f63d3d746ad76ceb7fe5facc23ef09d3e657"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8479540"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/363083a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022031225"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/363083a0", 
      "https://app.dimensions.ai/details/publication/pub.1022031225"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/363083a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/363083a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/363083a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/363083a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/363083a0'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      21 PREDICATES      77 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/363083a0 schema:about N03968cd77329429cb8a54198c97fcaf8
2 N346329b4c3c64ecba79ccf8f9132f96a
3 N3d1a562b2de64bf485bf63ed713fe9ad
4 N406d5899fe60453d8de5efe81ded3bf4
5 N491c802bb68d4a0985ce8c24980ba4f4
6 N525b6247f1e64c0eaf2210afff2387e7
7 N57a660c76ca943dab9ee8e843117767b
8 N62b5a57b48874e89b68c44e7b1c72a35
9 N76025167da514e3fba7b1908fdbb8919
10 N7e318c78a90f49109d4f94cbca8e8ef6
11 N9c24472acb8c408f8c29b32976c9d0a8
12 N9d722f09597e4741965b56b0f90fc867
13 Nac54809e7f2e4c93a9eb4761dd4f4c14
14 Nae99e1f756c54dd2b4e17ac55da6d580
15 Nafea01d5d3af47c4bb12c6db97ab47c0
16 Nd5df31acde334dfc96e5cfeaf39a6725
17 Ne80fc40806354c71a99cc49755f99b58
18 Need7cbe6e8664939993a0aac5369df5e
19 Nef2f91ed58ba451ab9405b10c86eddf0
20 Nf741133fe2274fe29ce2c00af31a075e
21 Nf93ed7505b9249d2815248bc25f8d6fa
22 anzsrc-for:06
23 anzsrc-for:0601
24 schema:author N9f3245fa1ee048cb8fdc8152bc6a78ab
25 schema:citation sg:pub.10.1038/313241a0
26 sg:pub.10.1038/320540a0
27 sg:pub.10.1038/356340a0
28 sg:pub.10.1038/358351a0
29 sg:pub.10.1038/360689a0
30 sg:pub.10.1038/360762a0
31 sg:pub.10.1038/363088a0
32 https://app.dimensions.ai/details/publication/pub.1078329566
33 https://doi.org/10.1002/j.1460-2075.1991.tb08050.x
34 https://doi.org/10.1016/0092-8674(91)90065-7
35 https://doi.org/10.1016/0092-8674(92)90075-n
36 https://doi.org/10.1016/0092-8674(92)90167-b
37 https://doi.org/10.1016/0092-8674(92)90536-l
38 https://doi.org/10.1016/0092-8674(93)90169-q
39 https://doi.org/10.1016/0092-8674(93)90170-u
40 https://doi.org/10.1016/0896-6273(91)90339-2
41 https://doi.org/10.1126/science.1280858
42 https://doi.org/10.1126/science.1379745
43 https://doi.org/10.1126/science.1496380
44 https://doi.org/10.1126/science.1604323
45 https://doi.org/10.1126/science.1736363
46 https://doi.org/10.1126/science.8438166
47 https://doi.org/10.1128/mcb.11.4.1804
48 https://doi.org/10.1128/mcb.11.5.2641
49 https://doi.org/10.1128/mcb.13.1.155
50 https://doi.org/10.1128/mcb.13.3.1345
51 https://doi.org/10.1128/mcb.13.3.1903
52 schema:datePublished 1993-05
53 schema:datePublishedReg 1993-05-01
54 schema:description Many tyrosine kinases, including the receptors for hormones such as epidermal growth factor (EGF), nerve growth factor and insulin, transmit intracellular signals through Ras proteins. Ligand binding to such receptors stimulates Ras guanine-nucleotide-exchange activity and increases the level of GTP-bound Ras, suggesting that these tyrosine kinases may activate a guanine-nucleotide releasing protein (GNRP). In Caenorhabditis elegans and Drosophila, genetic studies have shown that Ras activation by tyrosine kinases requires the protein Sem-5/drk, which contains a single Src-homology (SH) 2 domain and two flanking SH3 domains. Sem-5 is homologous to the mammalian protein Grb2, which binds the autophosphorylated EGF receptor and other phosphotyrosine-containing proteins such as Shc through its SH2 domain. Here we show that in rodent fibroblasts, the SH3 domains of Grb2 are bound to the proline-rich carboxy-terminal tail of mSos1, a protein homologous to Drosophila Sos. Sos is required for Ras signalling and contains a central domain related to known Ras-GNRPs. EGF stimulation induces binding of the Grb2-mSos1 complex to the autophosphorylated EGF receptor, and mSos1 phosphorylation. Grb2 therefore appears to link tyrosine kinases to a Ras-GNRP in mammalian cells.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N52d6816ee03d44a493227c964c6f37f8
59 N9046a850cdd14802a49620ec908f6726
60 sg:journal.1018957
61 schema:name The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
62 schema:pagination 83-85
63 schema:productId N7793ecd1652b49fc8e20dedd0472ce33
64 N89a2fd9383be4c1d8c7d38a053e8c06e
65 N98e11a5e9a504730bdde439abd2f37db
66 Na2471580ae284571b525a5cecf5ea66d
67 Nac8941eec9e64ba193531384fc3d3520
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022031225
69 https://doi.org/10.1038/363083a0
70 schema:sdDatePublished 2019-04-10T13:55
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N33ebfc993a4c4a78bf480ad83e38a245
73 schema:url http://www.nature.com/articles/363083a0
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N03968cd77329429cb8a54198c97fcaf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name GTP-Binding Proteins
79 rdf:type schema:DefinedTerm
80 N0a2d9cfd0125472aac260d286e33f31e rdf:first sg:person.01210702335.33
81 rdf:rest Nae5fe312fd9e413c921872c7633536ec
82 N21ebed6e774d4ac98f5a80811e39d083 rdf:first sg:person.0662770142.28
83 rdf:rest N0a2d9cfd0125472aac260d286e33f31e
84 N32fa6f64dfed473487dcfbc5ffa0d757 schema:name Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
85 rdf:type schema:Organization
86 N33ebfc993a4c4a78bf480ad83e38a245 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N346329b4c3c64ecba79ccf8f9132f96a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Protein-Tyrosine Kinases
90 rdf:type schema:DefinedTerm
91 N3d1a562b2de64bf485bf63ed713fe9ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name GRB2 Adaptor Protein
93 rdf:type schema:DefinedTerm
94 N406d5899fe60453d8de5efe81ded3bf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Signal Transduction
96 rdf:type schema:DefinedTerm
97 N491c802bb68d4a0985ce8c24980ba4f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Cells, Cultured
99 rdf:type schema:DefinedTerm
100 N525b6247f1e64c0eaf2210afff2387e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Rats
102 rdf:type schema:DefinedTerm
103 N52d6816ee03d44a493227c964c6f37f8 schema:volumeNumber 363
104 rdf:type schema:PublicationVolume
105 N57a660c76ca943dab9ee8e843117767b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Binding Sites
107 rdf:type schema:DefinedTerm
108 N62b5a57b48874e89b68c44e7b1c72a35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Molecular Sequence Data
110 rdf:type schema:DefinedTerm
111 N76025167da514e3fba7b1908fdbb8919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Membrane Proteins
113 rdf:type schema:DefinedTerm
114 N7793ecd1652b49fc8e20dedd0472ce33 schema:name readcube_id
115 schema:value 68f662d42e2433936125caab7280f63d3d746ad76ceb7fe5facc23ef09d3e657
116 rdf:type schema:PropertyValue
117 N7e318c78a90f49109d4f94cbca8e8ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name DNA
119 rdf:type schema:DefinedTerm
120 N89a2fd9383be4c1d8c7d38a053e8c06e schema:name doi
121 schema:value 10.1038/363083a0
122 rdf:type schema:PropertyValue
123 N9046a850cdd14802a49620ec908f6726 schema:issueNumber 6424
124 rdf:type schema:PublicationIssue
125 N98e11a5e9a504730bdde439abd2f37db schema:name pubmed_id
126 schema:value 8479540
127 rdf:type schema:PropertyValue
128 N9c24472acb8c408f8c29b32976c9d0a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Protein Binding
130 rdf:type schema:DefinedTerm
131 N9d722f09597e4741965b56b0f90fc867 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Receptor, Epidermal Growth Factor
133 rdf:type schema:DefinedTerm
134 N9f3245fa1ee048cb8fdc8152bc6a78ab rdf:first sg:person.01334671172.10
135 rdf:rest N21ebed6e774d4ac98f5a80811e39d083
136 Na2471580ae284571b525a5cecf5ea66d schema:name nlm_unique_id
137 schema:value 0410462
138 rdf:type schema:PropertyValue
139 Nac54809e7f2e4c93a9eb4761dd4f4c14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Animals
141 rdf:type schema:DefinedTerm
142 Nac8941eec9e64ba193531384fc3d3520 schema:name dimensions_id
143 schema:value pub.1022031225
144 rdf:type schema:PropertyValue
145 Nae5fe312fd9e413c921872c7633536ec rdf:first sg:person.01367636050.26
146 rdf:rest Nbecce21da56d4f19bf88f9caad7d3e3a
147 Nae99e1f756c54dd2b4e17ac55da6d580 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Adaptor Proteins, Signal Transducing
149 rdf:type schema:DefinedTerm
150 Nafea01d5d3af47c4bb12c6db97ab47c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name 3T3 Cells
152 rdf:type schema:DefinedTerm
153 Nbecce21da56d4f19bf88f9caad7d3e3a rdf:first sg:person.012102442677.58
154 rdf:rest rdf:nil
155 Nd5df31acde334dfc96e5cfeaf39a6725 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Son of Sevenless Proteins
157 rdf:type schema:DefinedTerm
158 Ne80fc40806354c71a99cc49755f99b58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Phosphorylation
160 rdf:type schema:DefinedTerm
161 Need7cbe6e8664939993a0aac5369df5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Humans
163 rdf:type schema:DefinedTerm
164 Nef2f91ed58ba451ab9405b10c86eddf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Amino Acid Sequence
166 rdf:type schema:DefinedTerm
167 Nf741133fe2274fe29ce2c00af31a075e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Mice
169 rdf:type schema:DefinedTerm
170 Nf93ed7505b9249d2815248bc25f8d6fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Proteins
172 rdf:type schema:DefinedTerm
173 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
174 schema:name Biological Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biochemistry and Cell Biology
178 rdf:type schema:DefinedTerm
179 sg:journal.1018957 schema:issn 0090-0028
180 1476-4687
181 schema:name Nature
182 rdf:type schema:Periodical
183 sg:person.012102442677.58 schema:familyName Bowtell
184 schema:givenName D
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012102442677.58
186 rdf:type schema:Person
187 sg:person.01210702335.33 schema:familyName Wade
188 schema:givenName J
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210702335.33
190 rdf:type schema:Person
191 sg:person.01334671172.10 schema:affiliation N32fa6f64dfed473487dcfbc5ffa0d757
192 schema:familyName Rozakis-Adcock
193 schema:givenName M
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334671172.10
195 rdf:type schema:Person
196 sg:person.01367636050.26 schema:familyName Pawson
197 schema:givenName T
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367636050.26
199 rdf:type schema:Person
200 sg:person.0662770142.28 schema:familyName Fernley
201 schema:givenName R
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662770142.28
203 rdf:type schema:Person
204 sg:pub.10.1038/313241a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052282285
205 https://doi.org/10.1038/313241a0
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/320540a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040637908
208 https://doi.org/10.1038/320540a0
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/356340a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022331632
211 https://doi.org/10.1038/356340a0
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/358351a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053445950
214 https://doi.org/10.1038/358351a0
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/360689a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042782556
217 https://doi.org/10.1038/360689a0
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/360762a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009718040
220 https://doi.org/10.1038/360762a0
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/363088a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012003451
223 https://doi.org/10.1038/363088a0
224 rdf:type schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1078329566 schema:CreativeWork
226 https://doi.org/10.1002/j.1460-2075.1991.tb08050.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078060028
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/0092-8674(91)90065-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004272509
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/0092-8674(92)90075-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1030097485
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/0092-8674(92)90167-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1023123401
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/0092-8674(92)90536-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1002935937
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0092-8674(93)90169-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1010009313
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/0092-8674(93)90170-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1031295172
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/0896-6273(91)90339-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005460711
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1126/science.1280858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062471978
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1126/science.1379745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062478197
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.1496380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062486253
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1126/science.1604323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062494790
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1126/science.1736363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002382243
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1126/science.8438166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655600
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1128/mcb.11.4.1804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023784363
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1128/mcb.11.5.2641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046843087
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1128/mcb.13.1.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005033955
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1128/mcb.13.3.1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045896855
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1128/mcb.13.3.1903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048963039
263 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...