Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-05

AUTHORS

S E Egan, B W Giddings, M W Brooks, L Buday, A M Sizeland, R A Weinberg

ABSTRACT

The proteins Grb2-Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation. More... »

PAGES

45-51

Journal

TITLE

Nature

ISSUE

6424

VOLUME

363

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/363045a0

DOI

http://dx.doi.org/10.1038/363045a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051359913

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8479536


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