Mutation of the mouse klotho gene leads to a syndrome resembling ageing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-11

AUTHORS

M Kuro-o, Y Matsumura, H Aizawa, H Kawaguchi, T Suga, T Utsugi, Y Ohyama, M Kurabayashi, T Kaname, E Kume, H Iwasaki, A Iida, T Shiraki-Iida, S Nishikawa, R Nagai, Y I Nabeshima

ABSTRACT

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases. More... »

PAGES

45-51

References to SciGraph publications

  • 1996-05. Mutation-causing mutations in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    6655

    VOLUME

    390

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/36285

    DOI

    http://dx.doi.org/10.1038/36285

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002866404

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9363890


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