Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-04

AUTHORS

D Moskophidis, F Lechner, H Pircher, R M Zinkernagel

ABSTRACT

Viruses that are non- or poorly cytopathic have developed various strategies to avoid elimination by the immune system and to persist in the host. Acute infection of adult mice with the noncytopathic lymphocytic choriomeningitis virus (LCMV) normally induces a protective cytotoxic T-cell response that also causes immunopathology. But some LCMV strains (such as DOCILE (LCMV-D) or Cl-13 Armstrong (Cl-13)) derived from virus carrier mice tend to persist after acute infection of adult mice without causing lethal immunopathological disease. Tendency to persist correlates with tropism, rapidity of virus spread and virus mutations. We report here that these LCMV isolates may persist because they induce most of the specific antiviral CD8+ cytotoxic T cells so completely that they all disappear within a few days and therefore neither eliminate the virus nor cause lethal immunopathology. The results illustrate that partially and sequentially induced (protective) immunity or complete exhaustion of T-cell immunity (high zone tolerance) are quantitatively different points on the scale of immunity; some viruses exploit the latter possibility to persist in an immunocompetent host. More... »

PAGES

758-761

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/362758a0

DOI

http://dx.doi.org/10.1038/362758a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049008808

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8469287


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