Instability and decay of the primary structure of DNA View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-04

AUTHORS

T Lindahl

ABSTRACT

Although DNA is the carrier of genetic information, it has limited chemical stability. Hydrolysis, oxidation and nonenzymatic methylation of DNA occur at significant rates in vivo, and are counteracted by specific DNA repair processes. The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils. More... »

PAGES

709-715

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/362709a0

DOI

http://dx.doi.org/10.1038/362709a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019428971

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8469282


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