Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-01

AUTHORS

G G Holz, W M Kühtreiber, J F Habener

ABSTRACT

Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a disorder of glucose homeostasis characterized by hyperglycaemia, peripheral insulin resistance, impaired hepatic glucose metabolism, and diminished glucose-dependent secretion of insulin from pancreatic beta-cells. Glucagon-like-peptide-1(7-37) (GLP-1) is an intestinally derived hormone that may be useful for the treatment of NIDDM because it acts in vivo to increase the level of circulating insulin, and thus lower the concentration of blood glucose. This therapeutic effect may result from the ability of GLP-1 to compensate for a defect in the glucose signalling pathway that regulates insulin secretion from beta-cells. In support of this concept we report here that GLP-1 confers glucose sensitivity to glucose-resistant beta-cells, a phenomenon we term glucose competence. Induction of glucose competence by GLP-1 results from its synergistic interaction with glucose to inhibit metabolically regulated potassium channels that are also targeted for inhibition by sulphonylurea drugs commonly used in the treatment of NIDDM. Glucose competence allows membrane depolarization, the generation of action potentials, and Ca2+ influx, events that are known to trigger insulin secretion. More... »

PAGES

362-365

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/361362a0

DOI

http://dx.doi.org/10.1038/361362a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031441956

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8381211


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