A synaptic model of memory: long-term potentiation in the hippocampus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-01

AUTHORS

T V Bliss, G L Collingridge

ABSTRACT

Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength. More... »

PAGES

31-39

Journal

TITLE

Nature

ISSUE

6407

VOLUME

361

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/361031a0

    DOI

    http://dx.doi.org/10.1038/361031a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042608618

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8421494


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