Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-12

AUTHORS

M Sendtner, B Holtmann, R Kolbeck, H Thoenen, Y A Barde

ABSTRACT

Motoneurons innervating the skeletal musculature were among the first neurons shown to require the presence of their target cells to develop appropriately. But the characterization of molecules allowing motoneuron survival has been difficult. Ciliary neurotrophic factor prevents the death of motoneurons, but its gene is not expressed during development. Although the presence of a neurotrophin receptor on developing motoneurons has suggested a role for neurotrophins, none could be shown to promote motoneuron survival in vitro. We report here that brain-derived neurotrophic factor can prevent the death of axotomized motoneurons in newborn rats, suggesting a role for this neurotrophin for motoneuron survival in vivo. More... »

PAGES

757-759

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/360757a0

DOI

http://dx.doi.org/10.1038/360757a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025667466

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1465147


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