α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-11

AUTHORS

M M Matzuk, M J Finegold, J G Su, A J Hsueh, A Bradley

ABSTRACT

The inhibins are alpha:beta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity. More... »

PAGES

313-319

Journal

TITLE

Nature

ISSUE

6402

VOLUME

360

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/360313a0

DOI

http://dx.doi.org/10.1038/360313a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052319710

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1448148


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