α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-11

AUTHORS

Martin M. Matzuk, Milton J. Finegold, Jyan-Gwo J. Su, Aaron J. W. Hsueh, Allan Bradley

ABSTRACT

The inhibins are α:β heterodimeric growth factors that are members of the transforming growth factor-β family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the α-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity. More... »

PAGES

313-319

Journal

TITLE

Nature

ISSUE

6402

VOLUME

360

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/360313a0

    DOI

    http://dx.doi.org/10.1038/360313a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052319710

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1448148


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