Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-11-12

AUTHORS

Frank Momburg, Vianney Ortiz-Navarrete, Jacques Neefjes, Els Goulmy, Yvonne van de Wal, Hergen Spits, Simon J. Powis, Geoffrey W. Butcher, Jonathan C. Howard, Peter Walden, Günter J. Hämmerling

ABSTRACT

MAJOR histocompatibility complex (MHC) class I molecules bind and deliver peptides derived from endogenously synthesized proteins to the cell surface for survey by cytotoxic T lymphocytes. It is believed that endogenous antigens are generally degraded in the cytosol, the resulting peptides being translocated into the endoplasmic reticulum where they bind to MHC class I molecules. Transporters containing an ATP-binding cassette encoded by the MHC class II region seem to be responsible for this transport1–8. Genes coding for two subunits of the '20S' proteasome (a multicatalytic proteinase) have been found in the vicinity of the two transporter genes in the MHC class II region, indicating that the proteasome could be the unknown proteolytic entity in the cytosol involved in the generation of MHC class I-binding peptides9–13. By introducing rat genes encoding the MHC-linked transporters into a human cell line lacking both transporter and proteasome subunit genes, we show here that the MHC-encoded proteasome subunits are not essential for stable MHC class I surface expression, or for processing and presentation of antigenic peptides from influenza virus and an intracellular protein. More... »

PAGES

174-177

References to SciGraph publications

  • 1992-02-13. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex in NATURE
  • 1992-04. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides in NATURE
  • 1982-08. Differential recognition of the serologically defined HLA-A2 antigen by allogeneic cytotoxic T Cells in IMMUNOGENETICS
  • 1991-10. Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex in NATURE
  • 1991-10. Second proteasome-related gene in the human MHC class II region in NATURE
  • 1992-02. Ham-2 corrects the class I antigen-processing defect in RMA-S cells in NATURE
  • 1991-09. A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC in NATURE
  • 1990-05-31. Presentation of viral antigen controlled by a gene in the major histocompatibility complex in NATURE
  • 1990-12. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters in NATURE
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  • 1992-05. Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule in NATURE
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  • 1990-11. A nucleoprotein peptide of influenza A virus stimulates assembly of HLA-B27 class I heavy chains and β2-micro-globulin translated in vitro in NATURE
  • 1991-10. Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene in NATURE
  • 1991-09. Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes in NATURE
  • 1991-12-26. Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter in NATURE
  • 1985-03. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids in IMMUNOGENETICS
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  • Journal

    TITLE

    Nature

    ISSUE

    6400

    VOLUME

    360

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/360174a0

    DOI

    http://dx.doi.org/10.1038/360174a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013551518

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1299222


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