Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-10

AUTHORS

J W Foster, F E Brennan, G K Hampikian, P N Goodfellow, A H Sinclair, R Lovell-Badge, L Selwood, M B Renfree, D W Cooper, J A Graves

ABSTRACT

In mammals, testis determination is under the control of the testis-determining factor borne by the Y chromosome. SRY, a gene cloned from the sex-determining region of the human Y chromosome, has been equated with the testis-determining factor in man and mouse. We have used a human SRY probe to identify and clone related genes from the Y chromosome of two marsupial species. Comparisons of eutherian and metatherian Y-located SRY sequences suggest rapid evolution of these genes, especially outside the region encoding the DNA-binding HMG box. The SRY homologues, together with the mouse Ube1y homologues, are the first genes to be identified on the marsupial Y chromosome. More... »

PAGES

531-533

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/359531a0

DOI

http://dx.doi.org/10.1038/359531a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028023362

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1406969


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