Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-02

AUTHORS

Andrew Fire, SiQun Xu, Mary K. Montgomery, Steven A. Kostas, Samuel E. Driver, Craig C. Mello

ABSTRACT

Experimental introduction of RNA into cells can be used in certain biological systems to interfere with the function of an endogenous gene. Such effects have been proposed to result from a simple antisense mechanism that depends on hybridization between the injected RNA and endogenous messenger RNA transcripts. RNA interference has been used in the nematode Caenorhabditis elegans to manipulate gene expression. Here we investigate the requirements for structure and delivery of the interfering RNA. To our surprise, we found that double-stranded RNA was substantially more effective at producing interference than was either strand individually. After injection into adult animals, purified single strands had at most a modest effect, whereas double-stranded mixtures caused potent and specific interference. The effects of this interference were evident in both the injected animals and their progeny. Only a few molecules of injected double-stranded RNA were required per affected cell, arguing against stochiometric interference with endogenous mRNA and suggesting that there could be a catalytic or amplification component in the interference process. More... »

PAGES

806

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6669

VOLUME

391

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  • Mrna Therapy For Phenylketonuria
  • Oligonucleotide Modulators Of The Toll-Like Receptor Pathway
  • Compositions Of Asymmetric Interfering Rna And Uses Thereof
  • Methods And Compositions For Isolating Small Rna Molecules
  • Human Chondroitinase Glycoprotein (Chasegp), Process For Preparing The Same, And Pharmaceutical Compositions Comprising Thereof
  • Post-Transcriptional Gene Silencing Using Expressed Double Stranded Rna
  • Drug Carrier And Drug Carrier Kit For Inhibiting Fibrosis
  • Nucleic Acid Constructs And Methods For Producing Altered Seed Oil Compositions
  • Methods For Producing Genetically Modified Animals Using Hypermethylated Transposons
  • Sirna Targeting Proto-Oncogene Met
  • Soybean Transgenic Event Mon87705 And Methods For Detection Thereof
  • Retinoid-Liposomes For Enhancing Modulation Of Hsp47 Expression
  • Nicked Or Gapped Nucleic Acid Molecules And Uses Thereof
  • Par-4 Antagonists For Use In The Treatment Or Prevention Of Influenza Virus Type A Infections
  • Methods And Compositions For Selecting Sirna Of Improved Functionality
  • Rnai Modulation Of Rsv And Therapeutic Uses Thereof
  • Nucleic Acid Constructs And Methods For Producing Altered Seed Oil Compositions
  • Nucleic Acid Sequences And Methods Of Use For The Production Of Plants With Modified Polyunsaturated Fatty Acids
  • Compositions For Dna Mediated Gene Silencing
  • Microrna-Related Nucleic Acids And Uses Thereof
  • Rnai Modulation Of Rsv And Therapeutic Uses Thereof
  • Pharmaceutical Compositions And Methods Useful For Modulating Angiogenesis, Inhibiting Metastasis And Tumor Fibrosis, And Assessing The Malignancy Of Colon Cancer Tumors
  • Rnai Modulation Of Rsv And Therapeutic Uses Thereof
  • Alteration Of Tobacco Alkaloid Content Through Modification Of Specific Cytochrome P450 Genes
  • Methods For The Synthesis Of Functionalized Nucleic Acids
  • Soybean Transgenic Event Mon87705 And Methods For Detection Thereof
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Method Of Regulating Gene Expression
  • Small Conditional Rnas
  • Vectors And Methods For High Throughput Co-Expression
  • Compositions Comprising Alternating 2′-Modified Nucleosides For Use In Gene Modulation
  • B7-H4 Expression On Tumor Vasculature
  • Pharmaceutical Compositions Comprising Small Interfering Rna Inhibitors Of Nox3
  • Sirna And Their Use In Methods And Compositions For Inhibiting The Expression Of The Pdk1 Gene
  • Treatment Of Cancer By Inhibition Of Igfbps And Clusterin
  • Biodegradable Poly(Β-Amino Esters) And Uses Thereof
  • Compositions And Methods For Silencing Genes Expressed In Cancer
  • Compositions And Methods For Sirna Inhibition Of Hif-1 Alpha
  • Oligonucleotide Complex Compositions And Methods Of Use As Gene Alteration Tools
  • Methods For Genetic Control Of Plant Pest Infestation And Compositions Thereof
  • Sirna And Their Use In Methods And Compositions For The Treatment And/Or Prevention Of Eye Conditions
  • Rna Interference Mediated Inhibition Of Gene Expression Using Short Interfering Nucleic Acids (Sina)
  • Compositions And Methods For Inhibition Of Expression Of Apolipoprotein C-Iii (Apoc3) Genes
  • Composition Of Anti-Endo180 Antibodies And Methods Of Use For The Treatment Of Cancer And Fibrotic Diseases
  • Methods Of Treating Transthyretin (Ttr) Mediated Amyloidosis
  • Sirnas And Their Use In Methods And Compositions For The Treatment And/Or Prevention Of Eye Conditions
  • Methods And Compositions For Plant Pest Control
  • Therapeutic Targets In Cancer
  • Methods And Means For Obtaining Modified Phenotypes
  • Pharmaceutical Agents For Treating Hcv Infections
  • Drug Carrier And Drug Carrier Kit For Inhibiting Fibrosis
  • Rna Interference Pathway Genes As Tools For Targeted Genetic Interference
  • Interfering Rna Molecules
  • Rna Interference Mediated Inhibition Of Platelet-Derived Endothelial Cell Growth Factor (Ecgf1) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Compositions And Methods For Inhibiting Expression Of Anti-Apoptotic Genes
  • Sirna And Methods Of Manufacture
  • Sirna Target Hypoxia-Inducible Factor 1
  • Rna Interference Mediated Inhibition Of Hepatitis C Virus (Hcv) Expression Using Short Interfering Nucleic Acid (Sina)
  • Par-1 Antagonists For Use In The Treatment Or Prevention Of Influenza Virus Type A Infections
  • Irna Agents Targeting Vegf
  • Tobacco Nicotine Demethylase Genomic Clone And Uses Thereof
  • Compositions And Methods For Sirna Inhibition Of Angiogenesis
  • Methods Of Treating Ocular Conditions
  • Rna Interference Mediated Inhibition Of Matrix Metalloproteinase 13 (Mmp13) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Methods Of Treating Eye Diseases In Diabetic Patients
  • Rna Interference Mediated Inhibition Of Interleukin And Interleukin Receptor Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Treatment Of Eye Disorders Characterized By An Elevated Intraocular Pressure By Sirnas
  • Methods And Compositions For Synthesis Of Nucleic Acid Molecules Using Multiple Recognition Sites
  • Sirna Targeting Cyclin-Dependent Kinase 4 (Cdk4)
  • Expression Cassettes For Transgenic Expression Of Nucleic Acids
  • Bioinformatically Detectable Group Of Novel Regulatory Oligonucleotides And Uses Thereof
  • Conjugates And Compositions For Cellular Delivery
  • Methods And Means For Producing Efficient Silencing Construct Using Recombinational Cloning
  • Methods And Compositions For The Treatment Of Intestinal Conditions
  • Sirna Targeting Amyloid Beta (A4) Precursor Protein (App)
  • Compositions And Methods For Inhibiting Expression Of Nav1.8 Gene
  • Treatment Of Eye Disorders Characterized By An Elevated Intraocular Pressure By Sirnas
  • Compositions And Methods For Inhibiting Expression Of Xbp-1 Gene
  • Recombinant Constructs And Their Use In Reducing Gene Expression
  • Rna Interference Mediated Inhibition Of Grb2 Associated Binding Protein (Gab2) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Rna Interference Mediated Inhibition Of Muscarinic Colinergic Receptor Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Regulatory Nucleic Acid Of A Human Proteinase 3 - Variant
  • Par-1 Antagonists For Use In The Treatment Or Prevention Of Influenza Virus Type A Infections
  • Conjugates And Compositions For Cellular Delivery
  • Sirna Targeting Tumor Protein 53 (P53)
  • Sirna Targeting Tata Box Binding Protein (Tbp)-Associated Factor (Taf1)
  • Rna Interference Mediated Inhibition Of Muscarinic Colinergic Receptor Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Modified Irna Agents
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rna Silencing
  • Multiple Promoter Expression Cassettes For Simultaneous Delivery Of Rnai Agents Targeted To Hepatitis C Virus
  • Methods Of Generating High-Production Of Antibodies From Hybridomas Created By In Vitro Immunization
  • Control Of Gene Expression
  • Compositions And Methods For Inhibiting Expression Of A Gene From The Jc Virus
  • Methods And Compositions Concerning Sirna's As Mediators Of Rna Interference
  • 2′-Fluoro Substituted Oligomeric Compounds And Compositions For Use In Gene Modulations
  • Sirna Targeting Proto-Oncogene Met
  • Compositions And Methods For Delivering Rnai Using Lipoproteins
  • Expression Cassettes For Transgenic Expression Of Nucleic Acids
  • Rna Interference Mediated Inhibition Of Respiratory Syncytial Virus (Rsv) Expression Using Short Interfering Nucleic Acid (Sina)
  • Analysing Sequencing Bias
  • Methods For Shp1 Mediated Neuroprotection
  • Human Mitogenic Oxidase
  • Polynucleotides Encoding Cellular Transporters And Methods Of Use Thereof
  • Antimicrobial Methods And Materials
  • Methods And Compositions For Dna Mediated Gene Silencing
  • Methods For Modulating Ikkα Activity
  • Rna Interference Mediated Inhibition Of Vascular Endothelial Growth Factor And Vascular Endothelial Growth Factor Receptor Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Sirna Targeting Interleukin-1 Receptor-Associated Kinase 4(Irak4)
  • Methods And Compositions Relating To Labeled Rna Molecules That Reduce Gene Expression
  • Delivery Of Sirna By Neutral Lipid Compositions
  • Rna Interference Mediating Small Rna Molecules
  • Biodegradable Lipids For Delivery Of Nucleic Acids
  • Methods And Compositions For Plant Pest Control
  • Means And Methods For Treating Or Preventing Brain Tumors Based On The Nuclear Receptor Tailless (Tlx)
  • Compositions And Methods For Inhibiting Expression Of The Hamp Gene
  • Processes For The Preparation Of Lipophilic Drug Delivery Vehicles
  • Lipophilic Nucleic Acid Delivery Vehicle And Methods Of Use Thereof
  • Virus Resistant Transgenic Silkworm
  • Compositions And Methods For Inhibiting Expression Of Anti-Apoptotic Genes
  • Interfering Rna Molecules
  • Diagnosis, Prevention And Treatment Of Cancer
  • Method For The Synthesis Of Phosphorus Atom Modified Nucleic Acids
  • Self Assembled Films For Protein And Drug Delivery Applications
  • Modified Irna Agents
  • Rnai Agents, Compositions And Methods Of Use Thereof For Treating Transthyretin (Ttr) Associated Diseases
  • Versatile Nucleic Acid Hairpin Motif For Programming Biomolecular Self-Assembly Pathways
  • Asymmetric Auxiliary Group
  • Chiral Control
  • Methods For Increasing Efficacy Of Lipid Formulated Sirna
  • Compositions And Methods For Sirna Inhibition Of Angiogenesis
  • Nucleic Acids Encoding Anthelmintic Agents And Plants Made Therefrom
  • Tetrahydropyran Nucleic Acid Analogs
  • Methods For Purification Of Messenger Rna
  • Method For Expression Of Small Antiviral Rna Molecules With Reduced Cytotoxicity Within A Cell
  • Compositions And Methods For Reducing Or Protecting Against Delayed Graft Function (Dgf)
  • Cns Targeting Aav Vectors And Methods Of Use Thereof
  • Irna Agents With Biocleavable Tethers
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Methods And Compositions For Increasing Invertase Activity In Plants
  • Alkaline Microbial Enhanced Oil Recovery
  • Cd40-Related Receptor That Binds Cd40l
  • Targeted Polypeptide Degradation
  • Rna Interference Mediating Small Rna Molecules
  • Methods For Treating Edema By Administering A Soluble Hyaluronidase Glycoprotein (Shasegp)
  • Monoclonal Antibodies With Enhanced Adcc Function
  • Disulfide-Linked Polyethyleneglycol/Peptide Conjugates For The Transfection Of Nucleic Acids
  • Micrornas
  • Phthalazinone Derivatives
  • Mammalian Cell Line Models And Related Methods
  • Irna Agents Targeting Vegf
  • Methods And Compositions For Rna Interference
  • Methods For Increasing Susceptibility To Apoptosis By Administering An Inhibitor Of Kallikrein 6 Polypeptide Activity
  • Methods And Compositions For Modulating Gene Expression Using Oligonucleotide Based Drugs Administered In Vivo Or In Vitro
  • Rnai Expression Constructs
  • Oligomeric Compounds Comprising Tricyclic Nucelosides And Methods For Their Use
  • Sirna Targeting Connective Tissue Growth Factor (Ctgf)
  • Tetrahydropyran Nucleic Acid Analogs
  • A Transgenic Plant Of The Type Of Solanum Tuberosum With Resistance To Phytophthora
  • Rnai For The Control Of Insects And Arachnids
  • Oligonucleotide Modulators Of The Toll-Like Receptor Pathway
  • Rna Interference Mediating Small Rna Molecules
  • Compositions And Methods For Mediating Rnai In Vivo
  • Rnai Modulation Of Apob And Uses Thereof
  • Methods And Compositions For Weed Control
  • Cftr Mrna Compositions And Related Methods And Uses
  • Double-Stranded Oligonucleotides
  • Rna Interference Mediating Small Rna Molecules
  • Rna Interference Mediating Small Rna Molecules
  • Means And Methods Of Using A Nadph Oxidase Inhibitor For The Treatment Of Hearing Loss And Phantom Hearing
  • End-Modified Poly(Beta-Amino Esters) And Uses Thereof
  • Soluble Glycosaminoglycanases And Methods Of Preparing And Using Soluble Glycosaminoglycanases
  • Compositions And Methods For Inhibiting Viral Replication
  • Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
  • Tetrahydropyran Nucleic Acid Analogs
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Genetic Markers Associated With Risk Of Diabetes Mellitus
  • Muc1 And Galectin-3
  • Means For Inhibiting The Expression Of Protein Kinase 3
  • Interfering Rna Molecules
  • Rna Aptamers Against Baff-R As Cell-Type Specific Delivery Agents And Methods For Their Use
  • Disulfide-Linked Polyethyleneglycol/Peptide Conjugates For The Transfection Of Nucleic Acids
  • Nucleic Acids And Proteins Of C. Elegans Insulin-Like Genes And Uses Thereof
  • Synthesis Of Deuterated Ribo Nucleosides, N-Protected Phosphoramidites And Oligonucleotides
  • Alteration Of Tobacco Alkaloid Content Through Modification Of Specific Cytochrome P450 Genes
  • Alteration Of Tobacco Alkaloid Content Through Modification Of Specific Cytochrome P450 Genes
  • Engineering And Optimization Of Systems, Methods And Compositions For Sequence Manipulation With Functional Domains
  • Enhancement Of Influenza Gene Expression
  • Nucleic Acid Molecules And Collections Thereof, Their Application And Identification
  • Tetrahydropyran Nucleic Acid Analogs
  • Targeted Delivery Of Nucleic Acids
  • Rna Aptamers Against Baff-R As Cell-Type Specific Delivery Agents And Methods For Their Use
  • Method For Increasing Sucrose Yield In Agricultural Production Of Sugar Beet And Sugar Cane
  • Method Of Identifying Myelodysplastic Syndromes
  • Increasing The Expression Of A Transgene In Eukaryotic Cells By Reducing Rna Interference
  • Bicyclic Nucleosides And Oligomeric Compounds Prepared Therefrom
  • Oligoribonucleotide Or Peptide Nucleic Acid Capable Of Inhibiting Activity Of Hepatitis C Virus
  • Compositions Comprising Alternating 2′-Modified Nucleosides For Use In Gene Modulation
  • Bioactive Agent Delivery Particles
  • Sirna Conjugate And Preparation Method Thereof
  • Methods And Compositions For Weed Control
  • Methods And Means For Obtaining Modified Phenotypes
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Combined Hairpin-Antisense Compositions And Methods For Modulating Expression
  • Nicotiana Nucleic Acid Molecules And Uses Thereof
  • Genetic Variants On Chr 5p12 And 10q26 As Markers For Use In Breast Cancer Risk Assessment, Diagnosis, Prognosis And Treatment
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Antigenic Compositions And Use Of Same In The Targeted Delivery Of Nucleic Acids
  • Retinoid-Liposomes For Treating Fibrosis
  • Methods And Compositions For Rna Interference
  • Bicyclic Cyclohexitol Nucleic Acid Analogs
  • Gnaq Targeted Dsrna Compositions And Methods For Inhibiting Expression
  • Interfering Rna Molecules
  • Compositions And Methods For Controlling Leptinotarsa
  • Costimulatory B7-H1 In Renal Cell Carcinoma Patients: Indicator Of Tumor Aggressiveness And Potential Therapeutic Target
  • Methods And Means For Obtaining Modified Phenotypes
  • Therapeutic Compositions
  • Anionic Polymer, Polyion Complex And Ternary Polymer Composite Using Anionic Polymer, And Pharmaceutical Composition
  • Rna Interference Mediating Small Rna Molecules
  • Tetrahydropyran Nucleic Acid Analogs
  • Synthetic Genes And Genetic Constructs
  • Sirna Targeting Connective Tissue Growth Factor (Ctgf)
  • Rnai Modulation Of Aha And Therapeutic Uses Thereof
  • Methods Of Making Decomposable Thin Films Of Polyelectrolytes And Uses Thereof
  • Rnai Expression Constructs With Liver-Specific Enhancer/Promoter
  • Rna Interference Mediated Inhibition Of Human Immunodeficiency Virus (Hiv) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Vectors And Methods For High Throughput Co-Expressions
  • Methods And Compositions For The Treatment Of Eye Disorders With Increased Intraocular Pressure
  • Sirna Targeting Glucagon Receptor (Gcgr)
  • Sirna Targeting Apolipoprotein B (Apob)
  • Drug Carrier And Drug Carrier Kit For Inhibiting Fibrosis
  • Method Using Snail Transcriptional Repressor
  • In Vivo Production Of Small Interfering Rnas That Mediate Gene Silencing
  • Rna Interference Mediated Inhibition Of Tnf And Tnf Receptor Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Compositions And Methods For Inhibiting Expression Of Huntingtin Gene
  • Methods And Compositions For Seamless Cloning Of Nucleic Acid Molecules
  • Polycation-Functionalized Nanoporous Silicon Carrier For Systemic Delivery Of Gene Silencing Agents
  • Polynucleotides For Multivalent Rna Interference, Compositions And Methods Of Use Thereof
  • Short Interfering Rna (Sirna) Analogues
  • Soluble Glycosaminoglycanases And Methods Of Preparing And Using Soluble Glycosaminoglycanases
  • Lipid Formulations For Delivery Of Messenger Rna
  • Treatment Or Prevention Of Oto-Pathologies By Inhibition Of Pro-Apoptotic Genes
  • Methods And Compositions For Isolating Small Rna Molecules
  • Methods For Delivery Of Sirna To The Spinal Cord And Therapies Arising Therefrom
  • Viral And Viral Associated Mirnas And Uses Thereof
  • Rnai Modulation Of Apob And Uses Thereof
  • Synthetic Genes And Genetic Constructs Comprising Same I
  • Soluble Hyaluronidase Glycoprotein (Shasegp), Process For Preparing The Same, Uses And Pharmaceutical Compositions Comprising Thereof
  • Methods And Compositions For Root Knot Nematode Control
  • Tobacco Inbred And Hybrid Plants And Tobacco Products Made Thereof
  • Modulation Of Transthyretin Expression
  • Isolation Of Novel Aav's And Uses Thereof
  • Interfering Rna Molecules
  • Compositions And Methods For Sirna Inhibition Of Angiogenesis
  • Methods For Reducing Intraocular Pressure By Administering A Soluble Hyaluronidase Glycoprotein (Shasegp)
  • Tobacco Inbred And Hybrid Plants And Uses Thereof
  • Synthesis Of Deuterated Ribo Nucleosides, N-Protected Phosphoramidites, And Oligonucleotides
  • Protein Surface Remodeling
  • Method For Treating Fibrosis Using Sirna And A Retinoid-Lipid Drug Carrier
  • Combination Of Anti-Clusterin Oligonucleotide With Hsp90 Inhibitor For The Treatment Of Prostate Cancer
  • Substituted 2′-Thio-Bicyclic Nucleosides And Oligomeric Compounds Prepared Therefrom
  • Method For Screening Transgenic Plants For Anthelmintic Activity
  • Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Fibrotic Conditions And Other Diseases
  • Method Of Designing Sirnas For Gene Silencing
  • Prevention And Treatment Of Acute Renal Failure And Other Kidney Diseases By Inhibition Of P53 By Sirna
  • Rna Interference Mediated Inhibition Of Myc And/Or Myb Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Relaxin-3 Chimeric Polypeptides And Their Preparation And Use
  • Allele-Specific Rna Interference
  • Rna Interference Mediated Inhibition Of Protein Tyrosine Phosphatase-1b (Ptp-1b) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Rna Interference Mediated Inhibition Of Telomerase Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Cationic Liposomes For The Delivery Of High Molecular Weight Compounds
  • C-Met Sirna Adenovirus Vectors Inhibit Cancer Cell Growth, Invasion And Tumorigenicity
  • Methods And Compositions For The Treatment Of Eye Disorders With Increased Intraocular Pressure
  • Antisense Modulation Of Cd40 Expression
  • Antibodies To Interleukin-Like Epithelial-Mesenchymal Transition Inducer (Ilei)
  • Irna Agents With Biocleavable Tethers
  • Methods And Means For Producing Efficient Silencing Construct Using Recombinational Cloning
  • Methods And Compositions For Rna Interference Using Recombinant Dicer And Argonaut
  • Compositions And Methods For Inhibiting Expression Of A Mutant Gene
  • Ship-Deficiency To Increase Megakaryocyte Progenitor Production
  • Cloning Of Cytochrome P450 Genes From Nicotiana
  • Modulation Of Eif4e-Bp2 Expression
  • Ship-Deficiency To Increase Megakaryocyte Progenitor Production
  • Highly Branched Hk Peptides As Effective Carriers Of Sirna
  • Sirna Having Antiviral Activity Against Nonpolio Enterovirus
  • Methods Of Treatment Of Acute Renal Failure
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Genetic Inhibition By Double-Stranded Rna
  • Nicotiana Nucleic Acid Molecules And Uses Thereof
  • Small Molecules Modulating Activity Of Micro Rna Oligonucleotides And Micro Rna Targets And Uses Thereof
  • Methods And Compositions For Selecting Sirna Of Improved Functionality
  • Methods And Compositions Involving Nkg2d Inhibitors And Cancer
  • Isolated Dsrna Molecules And Methods Of Using Same For Silencing Target Molecules Of Interest
  • Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
  • Composition For Preventing Or Treating Rheumatoid Arthritis
  • Chemically Modified Multifunctional Short Interfering Nucleic Acid Molecules That Mediate Rna Interference
  • Liquid Pharmaceutical Formulations For Injection Comprising Thiamine Pyrophosphate 1-(3-Aminopropyl)-2-Methyl-1h-Imidazole And Uses Thereof
  • Methods And Compositions For Treating Neurological Disease
  • Mitogenic Oxygenases
  • Rna Interference Pathway Genes As Tools For Targeted Genetic Interference
  • Control Of Post-Transcriptional Gene Silencing In Plants
  • Genetic Inhibition By Double-Stranded Rna
  • Modified Irna Agents
  • Gene Silencing
  • Compositions For Bacterial Mediated Gene Silencing And Methods Of Using Same
  • Methods And Compositions For Rna Interference
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Compositions And Methods For Inhibiting Expression Of The Hamp Gene
  • Clusterin Antisense Therapy For Treatment Of Cancer
  • Double-Stranded Lipid-Modified Rna Having High Rna Interference Effect
  • Sirna And Their Use In Methods And Compositions For Inhibiting The Expression Of The Orai1 Gene
  • Sirna And Their Use In Methods And Compositions For Inhibiting The Expression Of The Flap Gene.
  • Rna Interference Mediating Small Rna Molecules
  • Modulation Of Ptp1b Signal Transduction By Rna Interference
  • Specific Inhibition Of Gene Expression By Small Double Stranded Rnas
  • Telomerase Interference
  • Control Of Post-Transcriptional Gene Silencing In Plants
  • Nucleic Acids Encoding Anthelmintic Agents And Plants Made Therefrom
  • Polyamine-Fatty Acid Derived Lipidoids And Uses Thereof
  • Synthesis Of Deuterated Ribo Nucleosides, N-Protected Phosphoramidites, And Oligonucleotides
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Soluble Hyaluronidase Glycoprotein (Shasegp), Process For Preparing The Same, Uses And Pharmaceutical Compositions Comprising Thereof
  • Use Of Egfr Inhibitors To Prevent Or Treat Obesity
  • Liquid Protein Formulations For Injection Comprising 1-Butyl-3-Methylimidazolium Methanesulfonate And Uses Thereof
  • Interfering Rna Molecules
  • Rna Interference Mediating Small Rna Molecules
  • Chimeric Oligomeric Compounds And Their Use In Gene Modulation
  • Compositions And Methods For Inhibiting Expression Of A Gene From The Jc Virus
  • Bacteria Mediated Gene Silencing
  • Methods And Compositions For The Treatment Of Eye Disorders With Increased Intraocular Pressure
  • Rnai Modulation Of Rsv, Piv And Other Respiratory Viruses And Uses Thereof
  • Synthetic Lariat Rna For Rna Interference
  • Cloning Of Cytochrome P450 Genes From Nicotiana
  • Compositions Comprising Sirna And Plasmids
  • Compositions And Methods For Nucleic Acid Delivery
  • Compositions And Methods For Inhibiting Expression Of The Hamp Gene
  • Compositions And Methods For Selective Inhibition Of Vegf
  • Inhibition Of Bolting And Flowering Of A Beta Vulgaris Plant
  • Lipid Formulated Compositions And Methods For Inhibiting Expression Of Serum Amyloid A Gene
  • Phthalazinone Derivatives
  • Methods And Means For Obtaining Modified Phenotypes
  • Irna Agents Targeting Vegf
  • Chemically Modified Rna For Immunpstimulation
  • Rnai Modulation Of Mll-Af4 And Uses Thereof
  • Genetic Variants Contributing To Risk Of Prostate Cancer
  • Irna Agents With Biocleavable Tethers
  • Rna Interference Mediating Small Rna Molecules
  • Genetic Markers For Risk Management Of Atrial Fibrillation And Stroke
  • Nucleic Acid Sequences And Methods Of Use For The Production Of Plants With Modified Polyunsaturated Fatty Acids
  • Rnai For The Control Of Insects And Arachnids
  • Methods And Compositions For The Treatment Of Eye Disorders With Increased Intraocular Pressure
  • Compositions Of A Peptide-Based System For Cell-Specific Targeting
  • Methods And Compositions For Selecting Sirna Of Improved Functionality
  • Sirna Targeting Myeloid Differentiation Primary Response Gene (88) (Myd88)
  • Oligomeric Compounds Comprising Tricyclic Nucelosides And Methods For Their Use
  • Rna Interference Mediating Small Rna Molecules
  • Compounds And Methods For Modulating Expression Of Gccr
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Metal Bisphosphonate Nanoparticles For Anti-Cancer Therapy And Imaging And For Treating Bone Disorders
  • Method Of Conferring Resistance Against A Fusarium Plant Disease
  • Compositions For Rna Interference And Methods Of Use Thereof
  • Biodegradable Poly(Beta-Amino Esters) And Uses Thereof
  • Genetically Modified Reduced-Browning Fruit-Producing Plant And Produced Fruit Thereof, And Method Of Obtaining Such
  • Positionally Modified Sirna Constructs
  • Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola Virus
  • Modified Gene Silencing
  • Short Interfering Rna (Sirna) Analogues
  • Methods And Compositions For Weed Control
  • Diagnosis And Treatment Of Disease
  • Methods Of Treating Ischemia-Reperfusion Injury With Sirnas
  • Sirna Conjugate And Preparation Method Thereof
  • Antibodies To Human Β-Adrenergic Receptor Kinase
  • Rna Interference Mediating Small Rna Molecules
  • Cns Targeting Aav Vectors And Methods Of Use Thereof
  • Lipid Formulated Compositions And Methods For Inhibiting Expression Of Transthyretin (Ttr)
  • Methods And Materials For Producing Transgenic Artiodactyls
  • Nucleic Acid Molecules Containing Recombination Sites And Methods Of Using The Same
  • Self-Assembled Polynucleotide Structure
  • Tobacco Nicotine Demethylase Genomic Clone And Uses Thereof
  • Control Of Gene Expression
  • Modulation Of 11beta-Hydroxysteriod Dehydrogenase 1 Expression For The Treatment Of Ocular Diseases
  • Compounds And Methods For Modulating Expression Of Gcgr
  • Sirna And Their Use In Methods And Compositions For The Treatment And/Or Prevention Of Eye Conditions
  • Nucleic Acid Molecules Encoding A Transmembrane Serine Protease 7, The Encoded Polypeptides And Methods Based Thereon
  • Short Interference Ribonucleic Acids For Treating Allegic Diseases
  • Aminoalcohol Lipidoids And Uses Thereof
  • In Vivo Production Of Small Interfering Rnas That Mediate Gene Silencing
  • High Potency Sirnas For Reducing The Expression Of Target Genes
  • Use Of A Decoy Protein That Interferes With The Hedgehog Signalling Pathway For The Manufacture Of A Medicament For Preventing, Inhibiting, And/Or Reversing Ocular Diseases Related With Ocular Neovascularization
  • Pharmaceutical Compositions And Methods Useful For Modulating Angiogenesis, Inhibiting Metastasis And Tumor Fibrosis, And Assessing The Malignancy Of Colon Cancer Tumors
  • Aminoalcohol Lipidoids And Uses Thereof
  • Method For Rapidly Screening Microbial Hosts To Identify Certain Strains With Improved Yield And/Or Quality In The Expression Of Heterologous Proteins
  • Rnai Targeting Sec61g
  • Means And Methods For Treating And/Or Preventing Natural Ahr Ligand-Dependent Cancer
  • Genetic Variants Contributing To Risk Of Prostate Cancer
  • Irna Agents With Biocleavable Tethers
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Methods And Compositions For The Treatment Of Eye Disorders With Increased Intraocular Pressure
  • Methods And Compositions For Weed Control
  • Genetically Modified Reduced-Browning Fruit-Producing Plant And Produced Fruit Thereof, And Method Of Obtaining Such
  • Control Of Gene Expression
  • Modulation Of 11beta-Hydroxysteriod Dehydrogenase 1 Expression For The Treatment Of Ocular Diseases
  • Compounds And Methods For Modulating Expression Of Gcgr
  • Sirna And Their Use In Methods And Compositions For The Treatment And/Or Prevention Of Eye Conditions
  • Self-Assembled Polynucleotide Structure
  • Compositions Of A Peptide-Based System For Cell-Specific Targeting
  • Nucleic Acid Sequences And Methods Of Use For The Production Of Plants With Modified Polyunsaturated Fatty Acids
  • Metal Bisphosphonate Nanoparticles For Anti-Cancer Therapy And Imaging And For Treating Bone Disorders
  • Lipid Formulated Compositions And Methods For Inhibiting Expression Of Serum Amyloid A Gene
  • Compositions And Methods For Inhibition Of Expression Of Protein C (Proc) Genes
  • Methods And Means For Obtaining Modified Phenotypes
  • Therapeutic Compositions
  • Fungal Strains
  • Composition For Preventing Or Treating Cachexia
  • Method For Conferring Resistance Or Tolerance Aganist Furovirus, Potyvirus, Tospovirus, And Cucomovirus To Plant Cells
  • Interfering Rna Molecules
  • Therapeutic Agent For Pulmonary Fibrosis
  • Methods And Means For Obtaining Modified Phenotypes
  • Cosmetic Designs And Products Using Intronic Rna
  • Tobacco Inbred Plants K326 Src, Cms K326 Src, K346 Src, Cms K346 Src, Nc1562-1 Src, Nctg-61 Src, Cms Nctg-61 Src And Hybrid Nc196 Src
  • Lipophilic Conjugated Irna Agents
  • Oligomeric Compounds Comprising 4′-Thionucleosides For Use In Gene Modulation
  • Compositions And Methods For Sirna Inhibition Of Icam-1
  • Double-Stranded Rna (Dsrna) And Method Of Use For Inhibiting Expression Of A Fusion Gene
  • Novel Drugs For Inhibition Of Gene Expression
  • Composition And Method For In Vivo And In Vitro Attenuation Of Gene Expression Using Double Stranded Rna
  • Functional And Hyperfunctional Sirna
  • Treatment Or Prevention Of Oto-Pathologies By Inhibition Of Pro-Apoptotic Genes
  • Rna Interference Mediated Inhibition Of Hypoxia Inducible Factor 1 (Hif1) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Coordinated Decrease And Increase Of Gene Expression Of More Than One Gene Using Transgenic Constructs
  • Compositions And Methods For Inhibiting Viral Replication
  • Antisense Agents Combining Strongly Bound Base-Modified Oligonucleotide And Artificial Nuclease
  • Compositions And Methods For Inhibiting Expression Of Anti-Apoptotic Genes
  • Irna Agents Targeted To The Rho-A Gene
  • Rna Interference Mediated Inhibition Of Matrix Metalloproteinase 13 (Mmp13) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Rna Interference Mediated Inhibition Of Nogo And Nogo Receptor Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Phthalazinone Derivatives
  • Bioinformatically Detectable Human Herpesvirus 5 Regulatory Gene
  • Rna Interference Mediated Inhibition Of Platelet-Derived Endothelial Cell Growth Factor (Ecgf1) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Gene Silencing Using Mrna-Cdna Hybrids
  • Compositions And Methods For Inhibiting Expression Of Eg5 Gene
  • Micrornas And Uses Thereof
  • Rnai Modulation Of Hif-1 And Therapeutic Uses Thereof
  • Therapeutic Uses Of Inhibitors Of Rtp801
  • Mammalian Genes Involved In Viral Infection And Tumor Suppression
  • Rna Interference Mediated Inhibition Of Myostatin Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Sirna Against P22phox
  • Oxocarbonamide Peptide Nucleic Acids And Methods Of Using Same
  • Methods And Compositions For Enhancing The Efficacy And Specificity Of Rna Silencing
  • Therapeutic Uses Of Inhibitors Of Rtp801
  • Sirna Targeting Tie-2
  • Rna Interference Mediated Treatment Of Alzheimer's Disease Using Short Interfering Nucleic Acid (Sina)
  • Synthetic Genes And Genetic Constructs
  • Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
  • Compositions And Methods For Preparing Short Rna Molecules And Other Nucleic Acids
  • Rna Interference Mediated Inhibition Of Muscarinic Colinergic Receptor Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Method And Means To Modulate Programmed Cell Death In Eukaryotic Cells
  • Soluble Glycosaminoglycanases And Methods Of Preparing And Using Soluble Glycosaminoglycanases
  • Bis-Modified Bicyclic Nucleic Acid Analogs
  • Methods For Modulating Ikkα Activity
  • Method For Making A 21 Nucleotide Double Stranded Rna Chemically Linked At One End
  • Nucleic Acids Encoding Anthelmintic Agents And Plants Made Therefrom
  • Oligomeric Compounds Comprising 4′-Thionucleosides For Use In Gene Modulation
  • Materials And Methods For Colorectal Cancer Screening, Diagnosis And Therapy
  • Modification Of Plant Lignin Content
  • Modulation Of Exportin 5 Expression
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Carbocyclic Bicyclic Nucleic Acid Analogs
  • Methods And Compositions For The Treatment Of Eye Disorders With Increased Intraocular Pressure
  • Ph Triggerable Polymeric Particles
  • Pkr Activation Via Hybridization Chain Reaction
  • Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
  • Treatment Of Cancer By Inhibition Of Igfbp's And Clusterin
  • Rna Interference Mediated Inhibition Of Nogo And Nogo Receptor Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Bicyclic Cyclohexose Nucleic Acid Analogs
  • Compositions And Methods For Inhibiting Expression Of Eg5 And Vegf Genes
  • Amine-Containing Lipidoids And Uses Thereof
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Methods And Compositions For Modulating Gene Expression Using Oligonucleotide Based Drugs Administered In Vivo Or In Vitro
  • Bicyclic Morpholino Compounds And Oligomeric Compounds Prepared Therefrom
  • B7-H3 And B7-H4, Novel Immunoregulatory Molecules
  • Poly(Beta-Amino Alcohols), Their Preparation, And Uses Thereof
  • Compositions And Methods For Inhibiting Expression Of Eg5 Gene
  • Small Molecule-Dependent Inteins And Uses Thereof
  • Compositions And Methods For Inhibiting Expression Of An Rna From West Nile Virus
  • Myostatin Inhibition For Enhancing Muscle And/Or Improving Muscle Function
  • Down-Regulation Of Gene Expression Using Artificial Micrornas
  • Peptide Having Angiogenesis Inhibitory Activity And Composition Containing Same
  • Oligonucleotide Compositions With Enhanced Efficiency
  • Sirna And Their Use In Methods And Compositions For Inhibiting The Expression Of The Flap Gene
  • Nucleic Acid Prodrugs And Methods Of Use Thereof
  • Methods And Compositions For Selecting Sirna Of Improved Functionality
  • Composition For Preventing Or Treating Sepsis
  • Transgenic Plant Of The Species Solanum Tuberosum With Resistance To Phytophthora
  • Antisense-Based Small Rna Agents Targeting The Gag Open Reading Frame Of Hiv-1 Rna
  • H-1 Pv Expressing Rnai Effectors Targeting Cdk9
  • Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
  • Cyclohexenyl Nucleic Acids Analogs
  • Nicotiana Nucleic Acid Molecules And Uses Thereof
  • Dsrna Induced Specific And Non-Specific Immunity In Crustaceans And Other Invertebrates And Biodelivery Vehicles For Use Therein
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Inhibitory Rna For Modulating The Molecular Function Of Zfat Gene
  • Nicotiana Nucleic Acid Molecules And Uses Thereof
  • Hybridization Chain Reaction Amplification For In Situ Imaging
  • Use Of Trim72 As A Target For Muscle And Heart Enhancer
  • Dsrna Delivery Composition And Methods Of Use
  • Treatment Of Cancer By Inhibition Of Igfbps And Clusterin
  • End-Modified Poly(Beta-Amino Esters) And Uses Thereof
  • Rna Interference Mediating Small Rna Molecules
  • Aminoalcohol Lipidoids And Uses Thereof
  • Poly Adp-Ribose Polymerase Sequences And Their Uses
  • Compositions Of A Peptide Targeting System For Treating Cancer
  • Method For Inhibiting Expression Of A Protein In A Hepatocyte
  • Rna Interference Mediated Inhibition Of Interleukin Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Inhibition Of Gene Expression In Vertebrates Using Double-Stranded Rna (Rnai)
  • Double Stranded Constructs Comprising One Or More Short Strands Hybridized To A Longer Strand
  • Filipil Compositions And Methods For Treating Cancer
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  • System For Delivering Therapeutic Agents Into Living Cells And Cells Nuclei
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  • 6-Modified Bicyclic Nucleic Acid Analogs
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  • Compositions For Rna Interference And Methods Of Use Thereof
  • Compositions And Methods For Sirna Inhibition Of Angiogenesis
  • Method Of Regulating Gene Expression
  • Methods And Compositions For Modulating Gene Expression Using Oligonucleotide Based Drugs Administered In Vivo Or In Vitro
  • Insect Control Agent
  • Materials And Methods For The Efficient Production Of Pasteuria
  • Alternatively Spliced Isoform Of Acetyl-Coa Carboxylase 2 (Acc2)
  • Methods For Isolating Novel Antimicrobial Agents From Hypermutable Mammalian Cells
  • Sirna And Their Use In Methods And Compositions For Inhibiting The Expression Of The Pdk1 Gene.
  • Materials And Methods For In Vitro Production Of Bacteria
  • Methods For Identifying Novel Therapeutics And Diagnostics In The P53 Pathway
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  • Modulation Of Transthyretin Expression
  • Genetic Constructs For Delaying Or Repressing The Expression Of A Target Gene
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  • Sirna-Mediated Gene Silencing
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  • Rnai Probes Targeting Cancer-Related Proteins
  • Methods For Producing Micrornas
  • Rna Interference Methods Using Dna-Rna Duplex Constructs
  • Sirna Conjugate And Preparation Method Thereof
  • Biodegradable Poly(Beta-Amino Esters) And Uses Thereof
  • Triggered Rnai
  • Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
  • A Delivery System For Targeted Delivery Of A Therapeutically Active Payload
  • Methods For Indentifying Compounds That Modulate Gluconeogenesis Through The Binding Of Creb To The Pgc-1 Promoter
  • Methods And Means For Obtaining Modified Phenotypes
  • Tunable Genetic Switch For Regulating Gene Expression
  • Composition And Methods For Treating Ischemic Damage
  • Method For Expression Of Small Antiviral Rna Molecules With Reduced Cytotoxicity Within A Cell
  • Nucleic Acid Molecules Containing Recombination Sites And Methods Of Using The Same
  • Modulation Of Tudor-Sn Expression
  • Rna Interference Mediated Inhibition Of Cxcr4 Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Therapeutic Uses Of Inhibitors Of Rtp801l
  • Rnai Modulation Of Apob And Uses Thereof
  • Compositions And Methods For Inhibiting Expression Of The Hamp Gene
  • Cftr Mrna Compositions And Related Methods And Uses
  • Compositions And Methods For Inhibiting Expression Of A Target Gene
  • Therapeutic Targeting Of Interleukins Using Sirna In Neutral Liposomes
  • Therapeutic Uses Of Inhibitors Of Rtp801
  • Methods And Compositions For The Treatment Of Intestinal Conditions
  • Modulation Of Eif4e-Bp2 Expression
  • Rna Interference Mediated Inhibition Of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (Sina)
  • Trpm-2 Antisense Therapy
  • Short Antisense Compounds With Gapmer Configuration
  • Method For The Synthesis Of Phosphorus Atom Modified Nucleic Acids
  • Triggered Rnai
  • Sirna-Mediated Gene Silencing
  • Base Modified Bicyclic Nucleosides And Oligomeric Compounds Prepared Therefrom
  • Modulation Of Eif4e-Bp1 Expression
  • Gapped Oligomeric Compounds Having Linked Bicyclic Sugar Moieties At The Termini
  • Mrna Therapy For Fabry Disease
  • Tobacco Nicotine Demethylase Genomic Clone And Uses Thereof
  • Compositions And Methods For Inhibiting Expression Of The Pcsk9 Gene
  • Method Of Regulating Gene Expression
  • Nucleic Acid Particles, Methods And Use Thereof
  • Genetic Variants For Breast Cancer Risk Assessment
  • Genetic Susceptibility Variants Associated With Cardiovascular Disease
  • Sequence-Specific Inhibition Of Small Rna Function
  • Lipid Formulated Dsrna Targeting The Pcsk9 Gene
  • Charge-Dynamic Polymers And Delivery Of Anionic Compounds
  • Double-Stranded Rna Compounds To Casp2 And Uses Thereof
  • Interfering Rna Molecules
  • Function Of Gpr4 In Vascular Inflammatory Response To Acidosis And Related Methods
  • Tandem Sirnas
  • Compositions And Methods For Modulating Skin Pigmentation
  • Method And Medicament For Inhibiting The Expression Of A Given Gene
  • Inhibitors Of Fpr2, Compositions And Uses Thereof For Modulating Influenza Virus Replication
  • Sequence-Specific Inhibition Of Small Rna Function
  • Lipophilic Drug Delivery Vehicle And Methods Of Use Thereof
  • B7-H1 And Methods Of Diagnosis, Prognosis, And Treatment Of Cancer
  • B7-H1 Antibodies And Method Of Use
  • Methods For Treating A Disease Characterized By An Excess Of Hyaluronan By Administering A Soluble Hyaluronidase Glycoprotein (Shasegp)
  • Putative Cytokinin Receptor And Methods For Use Thereof
  • Cloning Of Cytochrome P450 Genes From Nicotiana
  • Irf-5 Haplotypes In Systemic Lupus Erythematosus
  • Oligoribonucleotides And Methods Of Use Thereof For Treatment Of Alopecia, Acute Renal Failure And Other Diseases
  • Dose Selection Of Adjuvanted Synthetic Nanocarriers
  • Compositions And Methods For Inhibiting Expression Of The Pcsk9 Gene
  • Methods And Compositions For Prevention Or Treatment Of Rsv Infection
  • Rna Interference Mediated Inhibition Of Vascular Cell Adhesion Molecule (Vcam) Gene Expression Using Short Interfering Nucleic Acid (Sina)
  • Methods And Compositions For The Specific Inhibition Of Gene Expression By Double-Stranded Rna
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Compositions And Methods For Inhibiting Expression Of Transthyretin
  • Double-Stranded Rna Directed To Casp2 And Methods Of Use Thereof
  • Rtp801l Sirna Compounds And Methods Of Use Thereof
  • Rna Interference For The Treatment Of Gain-Of-Function Disorders
  • 1,3,5-Triazinane-2,4,6-Trione Derivatives And Uses Thereof
  • Rna Interference Mediating Small Rna Molecules
  • Nucleic Acid Having An Anti-Metabolic Syndrome Effect
  • Gnaq Targeted Dsrna Compositions And Methods For Inhibiting Expression
  • Rnai Targeting Znf205
  • Compositions And Methods For Inhibiting Expression Of Cd45 Gene
  • Sirna Targeting Apolipoprotein B (Apob)
  • Means And Methods For The Treatment Of Hearing Loss And Phantom Hearing
  • Therapeutic Compositions
  • Expression Of Mammalian Proteins In Pseudomonas Fluorescens
  • Compositions And Methods For Inhibiting Expression Of Cd45 Gene
  • Treatment Of Cancer By Inhibition Of Igfbps And Clusterin
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35888

    DOI

    http://dx.doi.org/10.1038/35888

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018713804

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9486653


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