Ontology type: schema:ScholarlyArticle
1992-08
AUTHORSGabriel Waksman, Dorothea Kominos, Scott C. Robertson, Nalin Pant, David Baltimore, Raymond B. Birge, David Cowburn, Hidesaburo Hanafusa, Bruce J. Mayer, Michael Overduin, Marilyn D. Resh, Carlos B. Rios, Lauren Silverman, John Kuriyan
ABSTRACTThree-dimensional structures of complexes of the SH2 domain of the v-src oncogene product with two phosphotyrosyl peptides have been determined by X-ray crystallography at resolutions of 1.5 and 2.0 Å, respectively. A central antiparallel β-sheet in the structure is flanked by two α-helices, with peptide binding mediated by the sheet, intervening loops and one of the helices. The specific recognition of phosphotyrosine involves amino–aromatic interactions between lysine and arginine side chains and the ring system in addition to hydrogen-bonding interactions with the phosphate. More... »
PAGES646-653
http://scigraph.springernature.com/pub.10.1038/358646a0
DOIhttp://dx.doi.org/10.1038/358646a0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/1379696
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