A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-08

AUTHORS

M Berry, F Grosveld, N Dillon

ABSTRACT

In normal humans the fetal stage-specific gamma-globin genes are silenced after birth and not expressed in the adult. Exceptions are seen in cases of hereditary persistence of fetal haemoglobin (HPFH). These are clinically important because the elevated levels of gamma-globin can alleviate beta-thalassaemia and sickle cell anaemia. One class of mutations is associated with point mutations in the promoter of the gamma-globin genes (non-deletion HPFH), whereas others seem to be caused by large deletions 3' to the gamma-globin genes. To test whether the point mutation found in the Greek non-deletion HPFH (guanine to adenine at nucleotide position -117) is the cause of the raised gamma-globin levels in the adult stage and is not just a linked polymorphism, we engineered this mutation into a gamma-globin gene. When this gene was introduced into mice, the presence of the -117 mutation results in persistence of gamma-globin expression at a high level and a concomitant decrease in beta-globin expression in fetal and adult mice. We show that these changes correlate with the loss of binding of the transcription factor GATA1 to the gamma-globin promoter, suggesting that it may act as a negative regulator of the gamma-globin gene in adults. More... »

PAGES

499-502

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/358499a0

DOI

http://dx.doi.org/10.1038/358499a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043495245

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1379347


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetal Hemoglobin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fetus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Globins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Greece", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemoglobinopathies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berry", 
        "givenName": "M", 
        "id": "sg:person.01132212630.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132212630.30"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Grosveld", 
        "givenName": "F", 
        "id": "sg:person.010064524477.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010064524477.44"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Dillon", 
        "givenName": "N", 
        "id": "sg:person.0675552716.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675552716.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/mcb.11.2.843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002090552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.5.8.1387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003501695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.5.2057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006722970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.12.6596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012908837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90483-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021977430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/17.16.6681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023936409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/350252a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026007026", 
          "https://doi.org/10.1038/350252a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.4.3.380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029486948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/313323a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030745598", 
          "https://doi.org/10.1038/313323a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.4.11.1886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036277795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/313325a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038846498", 
          "https://doi.org/10.1038/313325a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90584-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041471577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/344309a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042861416", 
          "https://doi.org/10.1038/344309a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.2.9.1089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052658367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2448875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062538000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07385.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078715791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078903582", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1988.tb03176.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079598373"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-08", 
    "datePublishedReg": "1992-08-01", 
    "description": "In normal humans the fetal stage-specific gamma-globin genes are silenced after birth and not expressed in the adult. Exceptions are seen in cases of hereditary persistence of fetal haemoglobin (HPFH). These are clinically important because the elevated levels of gamma-globin can alleviate beta-thalassaemia and sickle cell anaemia. One class of mutations is associated with point mutations in the promoter of the gamma-globin genes (non-deletion HPFH), whereas others seem to be caused by large deletions 3' to the gamma-globin genes. To test whether the point mutation found in the Greek non-deletion HPFH (guanine to adenine at nucleotide position -117) is the cause of the raised gamma-globin levels in the adult stage and is not just a linked polymorphism, we engineered this mutation into a gamma-globin gene. When this gene was introduced into mice, the presence of the -117 mutation results in persistence of gamma-globin expression at a high level and a concomitant decrease in beta-globin expression in fetal and adult mice. We show that these changes correlate with the loss of binding of the transcription factor GATA1 to the gamma-globin promoter, suggesting that it may act as a negative regulator of the gamma-globin gene in adults.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/358499a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6386", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "358"
      }
    ], 
    "name": "A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin", 
    "pagination": "499-502", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cf2f1551c73cc21b03836185060413e175974a19aca43310483a29ce050b57a7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1379347"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/358499a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043495245"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/358499a0", 
      "https://app.dimensions.ai/details/publication/pub.1043495245"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/358499a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/358499a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/358499a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/358499a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/358499a0'


 

This table displays all metadata directly associated to this object as RDF triples.

198 TRIPLES      21 PREDICATES      62 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/358499a0 schema:about N03b624a264444cf29f0a3fdefaa08b9b
2 N08390e337d7b4d41bea8013e7afd8217
3 N0c0bd1e65d194861b98ccd3da919d4e7
4 N33e67c42a72348ca865cd3c19891c0dc
5 N6957c01446294790b348fb20e3a50505
6 N9478793d88a4483b837e90f2ec190a19
7 Na5042b96a43b43cb89a562f141552e7b
8 Na6d73355bd514c77bcd2073abc725bc1
9 Na98e364f262d4fb2828a92a0c458fc9c
10 Nb4fdc3803539481eb6c93e15cb66272a
11 Nd0d8e1c4e21e41768cb4c8dcbfb5e690
12 Nd9d6a26110144024872f2811c95c3d5f
13 Ndadaed4a942047eabe37508d2eb5f8e1
14 Nf087a72637894b598b125f01a4f571da
15 Nffaab4ee56c1460e9f9be637e9eba1ee
16 anzsrc-for:06
17 anzsrc-for:0604
18 schema:author Na2e01177bc3b4ced964c5dad7e7b9321
19 schema:citation sg:pub.10.1038/313323a0
20 sg:pub.10.1038/313325a0
21 sg:pub.10.1038/344309a0
22 sg:pub.10.1038/350252a0
23 https://app.dimensions.ai/details/publication/pub.1078903582
24 https://doi.org/10.1002/j.1460-2075.1988.tb03176.x
25 https://doi.org/10.1002/j.1460-2075.1990.tb07385.x
26 https://doi.org/10.1016/0092-8674(87)90584-8
27 https://doi.org/10.1016/0092-8674(88)90483-7
28 https://doi.org/10.1093/nar/17.16.6681
29 https://doi.org/10.1101/gad.2.9.1089
30 https://doi.org/10.1101/gad.4.11.1886
31 https://doi.org/10.1101/gad.4.3.380
32 https://doi.org/10.1101/gad.5.8.1387
33 https://doi.org/10.1126/science.2448875
34 https://doi.org/10.1128/mcb.10.12.6596
35 https://doi.org/10.1128/mcb.11.2.843
36 https://doi.org/10.1128/mcb.12.5.2057
37 schema:datePublished 1992-08
38 schema:datePublishedReg 1992-08-01
39 schema:description In normal humans the fetal stage-specific gamma-globin genes are silenced after birth and not expressed in the adult. Exceptions are seen in cases of hereditary persistence of fetal haemoglobin (HPFH). These are clinically important because the elevated levels of gamma-globin can alleviate beta-thalassaemia and sickle cell anaemia. One class of mutations is associated with point mutations in the promoter of the gamma-globin genes (non-deletion HPFH), whereas others seem to be caused by large deletions 3' to the gamma-globin genes. To test whether the point mutation found in the Greek non-deletion HPFH (guanine to adenine at nucleotide position -117) is the cause of the raised gamma-globin levels in the adult stage and is not just a linked polymorphism, we engineered this mutation into a gamma-globin gene. When this gene was introduced into mice, the presence of the -117 mutation results in persistence of gamma-globin expression at a high level and a concomitant decrease in beta-globin expression in fetal and adult mice. We show that these changes correlate with the loss of binding of the transcription factor GATA1 to the gamma-globin promoter, suggesting that it may act as a negative regulator of the gamma-globin gene in adults.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf N34c7c453ad764b5bbc375b06fce51d63
44 N64ad3466b8fc4216923f58ec5e0aeb0e
45 sg:journal.1018957
46 schema:name A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin
47 schema:pagination 499-502
48 schema:productId N33012cd0183144f0a4099df098eac7ac
49 N415ea81122fc4c38a4f8f71701a86eae
50 N8aa4617771774530b2cf7209b9e91a7b
51 Nb91aea550fcc4ac38eeed4e334933f1b
52 Nf33d5a91e07a41e4b596fc129ebc1042
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043495245
54 https://doi.org/10.1038/358499a0
55 schema:sdDatePublished 2019-04-11T01:47
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher Nd755c482c828425aa14ef9bfa52ee0ae
58 schema:url http://www.nature.com/articles/358499a0
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N03b624a264444cf29f0a3fdefaa08b9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Transfection
64 rdf:type schema:DefinedTerm
65 N08390e337d7b4d41bea8013e7afd8217 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Molecular Sequence Data
67 rdf:type schema:DefinedTerm
68 N0c0bd1e65d194861b98ccd3da919d4e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Base Sequence
70 rdf:type schema:DefinedTerm
71 N33012cd0183144f0a4099df098eac7ac schema:name readcube_id
72 schema:value cf2f1551c73cc21b03836185060413e175974a19aca43310483a29ce050b57a7
73 rdf:type schema:PropertyValue
74 N33e67c42a72348ca865cd3c19891c0dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Animals
76 rdf:type schema:DefinedTerm
77 N34c7c453ad764b5bbc375b06fce51d63 schema:volumeNumber 358
78 rdf:type schema:PublicationVolume
79 N415ea81122fc4c38a4f8f71701a86eae schema:name pubmed_id
80 schema:value 1379347
81 rdf:type schema:PropertyValue
82 N434c2704689447d19e5b910c60600951 rdf:first sg:person.0675552716.08
83 rdf:rest rdf:nil
84 N64ad3466b8fc4216923f58ec5e0aeb0e schema:issueNumber 6386
85 rdf:type schema:PublicationIssue
86 N6957c01446294790b348fb20e3a50505 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Mutation
88 rdf:type schema:DefinedTerm
89 N8aa4617771774530b2cf7209b9e91a7b schema:name nlm_unique_id
90 schema:value 0410462
91 rdf:type schema:PropertyValue
92 N9478793d88a4483b837e90f2ec190a19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Fetal Hemoglobin
94 rdf:type schema:DefinedTerm
95 Na2e01177bc3b4ced964c5dad7e7b9321 rdf:first sg:person.01132212630.30
96 rdf:rest Ne45bf870ab344598ad48b8bfd1a05035
97 Na5042b96a43b43cb89a562f141552e7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Fetus
99 rdf:type schema:DefinedTerm
100 Na6d73355bd514c77bcd2073abc725bc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Humans
102 rdf:type schema:DefinedTerm
103 Na98e364f262d4fb2828a92a0c458fc9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Gene Expression Regulation
105 rdf:type schema:DefinedTerm
106 Nb4fdc3803539481eb6c93e15cb66272a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Promoter Regions, Genetic
108 rdf:type schema:DefinedTerm
109 Nb91aea550fcc4ac38eeed4e334933f1b schema:name dimensions_id
110 schema:value pub.1043495245
111 rdf:type schema:PropertyValue
112 Nd0d8e1c4e21e41768cb4c8dcbfb5e690 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mice
114 rdf:type schema:DefinedTerm
115 Nd755c482c828425aa14ef9bfa52ee0ae schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 Nd9d6a26110144024872f2811c95c3d5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Greece
119 rdf:type schema:DefinedTerm
120 Ndadaed4a942047eabe37508d2eb5f8e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Globins
122 rdf:type schema:DefinedTerm
123 Ne45bf870ab344598ad48b8bfd1a05035 rdf:first sg:person.010064524477.44
124 rdf:rest N434c2704689447d19e5b910c60600951
125 Nf087a72637894b598b125f01a4f571da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Hemoglobinopathies
127 rdf:type schema:DefinedTerm
128 Nf33d5a91e07a41e4b596fc129ebc1042 schema:name doi
129 schema:value 10.1038/358499a0
130 rdf:type schema:PropertyValue
131 Nffaab4ee56c1460e9f9be637e9eba1ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mice, Transgenic
133 rdf:type schema:DefinedTerm
134 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
135 schema:name Biological Sciences
136 rdf:type schema:DefinedTerm
137 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
138 schema:name Genetics
139 rdf:type schema:DefinedTerm
140 sg:journal.1018957 schema:issn 0090-0028
141 1476-4687
142 schema:name Nature
143 rdf:type schema:Periodical
144 sg:person.010064524477.44 schema:familyName Grosveld
145 schema:givenName F
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010064524477.44
147 rdf:type schema:Person
148 sg:person.01132212630.30 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
149 schema:familyName Berry
150 schema:givenName M
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132212630.30
152 rdf:type schema:Person
153 sg:person.0675552716.08 schema:familyName Dillon
154 schema:givenName N
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675552716.08
156 rdf:type schema:Person
157 sg:pub.10.1038/313323a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030745598
158 https://doi.org/10.1038/313323a0
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/313325a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038846498
161 https://doi.org/10.1038/313325a0
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/344309a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042861416
164 https://doi.org/10.1038/344309a0
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/350252a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026007026
167 https://doi.org/10.1038/350252a0
168 rdf:type schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1078903582 schema:CreativeWork
170 https://doi.org/10.1002/j.1460-2075.1988.tb03176.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079598373
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/j.1460-2075.1990.tb07385.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078715791
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/0092-8674(87)90584-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041471577
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/0092-8674(88)90483-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021977430
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1093/nar/17.16.6681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023936409
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1101/gad.2.9.1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052658367
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1101/gad.4.11.1886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036277795
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1101/gad.4.3.380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029486948
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1101/gad.5.8.1387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003501695
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1126/science.2448875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062538000
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1128/mcb.10.12.6596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012908837
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1128/mcb.11.2.843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002090552
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1128/mcb.12.5.2057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006722970
195 rdf:type schema:CreativeWork
196 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
197 schema:name Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK.
198 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...