Retinoblastoma protein switches the E2F site from positive to negative element View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-07

AUTHORS

Steven J. Weintraub, Cheryl A. Prater, Douglas C. Dean

ABSTRACT

ORIGINALLY E2F sites were identified as elements in the promoters of adenovirus early genes that are necessary for activation of these genes by the early protein E1a (ref. 1). E2F promoter elements have been shown to be important for transcriptional activation of several genes critical for progression through the cell cycle2–4. During the G1 phase of the cell cycle, the E2F protein forms a complex with the cell-cycle protein Rb (ref. 5) and it has been suggested that this binding of Rb to E2F inactivates E2F (ref. 5). Here we show that Rb-E2F is an active complex that, when bound to the E2F site, inhibits the activity of other promoter elements and thus silences transcription. We propose that the ability of this complex to inhibit transcription is integral to the function of Rb and provide evidence that E2F is a positive element in the absence of an active form of Rb. It has been shown that binding of Rb to E2F depends on the phosphorylation state of Rb (only the underphosphorylated form binds)5 and that the phosphorylation state of Rb changes during progression through the cell cycle6,7. We therefore suggest that the E2F site alternates between a positive and negative element with the phosphorylation/dephosphorylation cycle of Rb. This cyclic activity may be responsible for activating and then inhibiting genes during the cell cycle. More... »

PAGES

259-261

Journal

TITLE

Nature

ISSUE

6383

VOLUME

358

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/358259a0

DOI

http://dx.doi.org/10.1038/358259a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020237383

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1321348


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207 schema:name Departments of Medicine and Cell Biology and Physiology, Washington University School of Medicine, 660 S. Euclid, 63110, St Louis, Missouri, USA
208 rdf:type schema:Organization
 




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