Superantigen implicated in dependence of HIV-1 replication in T cells on TCR V β expression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-07-16

AUTHORS

Jeffrey Laurence, Andrew S. Hodtsev, David N. Posnett

ABSTRACT

IN the pathogenesis of AIDS it is not yet understood whether the small fraction of CD4+ T cells (~1%) infected with the human immunodeficiency virus (HIV) are randomly targeted or not. Here we present evidence that human CD4 T-cell lines expressing selected T-cell antigen receptor Vβ gene products can all be infected in vitro with HIV-1, but give markedly different titres of HIV-1 virion production. For example, Vβ12 T-cell lines from several unrelated donors reproducibly yielded up to 100-fold more gag gene product (p24gag antigen) than Vβ6.7a lines. This is consistent with a superantigen effect, because the Vβ selectivity was observed with several divergent HIV-1 isolates, was dependent on antigen-presenting cells and on major histocompatibility complex (MHC) class II but was not MHC class II-restricted. The in vivo significance of these findings is supported by the preferential stimulation of Vβ12+ T cells by freshly obtained irradiated antigen-presenting cells from some HIV-1-seropositive but not HIV-1-negative donors. Moreover, cells from patients positive for viral antigen (gp120) were enriched in the Vβ12 subpopulation. Vβ12+ T cells were not deleted in AIDS patients, however, raising the possibility that a variety of mechanisms contribute to T-cell depletion. Our results indicate that a superantigen targets a subpopulation of CD4+ cells for viral replication. More... »

PAGES

255-259

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/358255a0

DOI

http://dx.doi.org/10.1038/358255a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017730773

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1630494


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