Atomic structure and chemistry of human serum albumin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-07-16

AUTHORS

Xiao Min He, Daniel C. Carter

ABSTRACT

The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 Å. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and IIIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin. More... »

PAGES

209-215

Journal

TITLE

Nature

ISSUE

6383

VOLUME

358

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/358209a0

    DOI

    http://dx.doi.org/10.1038/358209a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015317638

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1630489


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