The mechanism of Z α1-antitrypsin accumulation in the liver View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-06

AUTHORS

D A Lomas, D L Evans, J T Finch, R W Carrell

ABSTRACT

Most northern Europeans have only the normal M form of the plasma protease inhibitor alpha 1-antitrypsin, but some 4% are heterozygotes for the Z deficiency variant. For reasons that have not been well-understood, the Z mutation results in a blockage in the final stage of processing of antitrypsin in the liver such that in the Z homozygote only 15% of the protein is secreted into the plasma. The 85% of the alpha 1-antitrypsin that is not secreted accumulates in the endoplasmic reticulum of the hepatocyte; much of it is degraded but the remainder aggregates to form insoluble intracellular inclusions. These inclusions are associated with hepatocellular damage, and 10% of newborn Z homozygotes develop liver disease which often leads to a fatal childhood cirrhosis. Here we demonstrate the molecular pathology underlying this accumulation and describe how the Z mutation in antitrypsin results in a unique molecular interaction between the reactive centre loop of one molecule and the gap in the A-sheet of another. This loop-sheet polymerization of Z antitrypsin occurs spontaneously at 37 degrees C and is completely blocked by the insertion of a specific peptide into the A-sheet of the antitrypsin molecule. Z antitrypsin polymerized in vitro has identical properties and ultrastructure to the inclusions isolated from hepatocytes of a Z homozygote. The concentration and temperature dependence of this loop-sheet polymerization has implications for the management of the liver disease of the newborn Z homozygote. More... »

PAGES

605-607

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/357605a0

DOI

http://dx.doi.org/10.1038/357605a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048738506

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1608473


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Circular Dichroism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macromolecular Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha 1-Antitrypsin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "alpha 1-Antitrypsin Deficiency", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Cambridge", 
          "id": "https://www.grid.ac/institutes/grid.5335.0", 
          "name": [
            "Department of Haematology, University of Cambridge, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lomas", 
        "givenName": "D A", 
        "id": "sg:person.01354415767.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354415767.17"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Evans", 
        "givenName": "D L", 
        "id": "sg:person.01161220636.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161220636.48"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Finch", 
        "givenName": "J T", 
        "id": "sg:person.01360454554.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360454554.29"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Carrell", 
        "givenName": "R W", 
        "id": "sg:person.01151114516.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151114516.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1990.tb19425.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012286765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci112731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017880552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021040660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(84)81279-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025591444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1975.tb02281.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028113473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(86)80908-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028442832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353576a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031775725", 
          "https://doi.org/10.1038/353576a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197501232920403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034101034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(91)80076-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053191512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(91)80076-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053191512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00449a001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055176679"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-06", 
    "datePublishedReg": "1992-06-01", 
    "description": "Most northern Europeans have only the normal M form of the plasma protease inhibitor alpha 1-antitrypsin, but some 4% are heterozygotes for the Z deficiency variant. For reasons that have not been well-understood, the Z mutation results in a blockage in the final stage of processing of antitrypsin in the liver such that in the Z homozygote only 15% of the protein is secreted into the plasma. The 85% of the alpha 1-antitrypsin that is not secreted accumulates in the endoplasmic reticulum of the hepatocyte; much of it is degraded but the remainder aggregates to form insoluble intracellular inclusions. These inclusions are associated with hepatocellular damage, and 10% of newborn Z homozygotes develop liver disease which often leads to a fatal childhood cirrhosis. Here we demonstrate the molecular pathology underlying this accumulation and describe how the Z mutation in antitrypsin results in a unique molecular interaction between the reactive centre loop of one molecule and the gap in the A-sheet of another. This loop-sheet polymerization of Z antitrypsin occurs spontaneously at 37 degrees C and is completely blocked by the insertion of a specific peptide into the A-sheet of the antitrypsin molecule. Z antitrypsin polymerized in vitro has identical properties and ultrastructure to the inclusions isolated from hepatocytes of a Z homozygote. The concentration and temperature dependence of this loop-sheet polymerization has implications for the management of the liver disease of the newborn Z homozygote.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/357605a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6379", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "357"
      }
    ], 
    "name": "The mechanism of Z \u03b11-antitrypsin accumulation in the liver", 
    "pagination": "605-607", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e82e80eb4c3c22e1cee3cb3664bd402974bd6f565f279fd9bf9e7d0a72989395"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1608473"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/357605a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048738506"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/357605a0", 
      "https://app.dimensions.ai/details/publication/pub.1048738506"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nature/journal/v357/n6379/full/357605a0.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/357605a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/357605a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/357605a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/357605a0'


 

This table displays all metadata directly associated to this object as RDF triples.

162 TRIPLES      21 PREDICATES      50 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/357605a0 schema:about N25924c13495c45bdb6a8604f460dd376
2 N3ae9b3a36ce546349e9330f5174094ea
3 N69fc2c78fb404215906f7c6e1eaf881d
4 N76a17cef44f14c1f850c263578a6f734
5 N9b685dc427d4439a8ec713d8414658b9
6 N9e2992b4eb604c719e8438e19552c92c
7 Na51cb90f3a4e4209a842db03b0cb1c04
8 Nb088a22bcdb94894935ca6745d434625
9 Nbbc97b408e234b26b337b7ca31e3401c
10 Nd3ca4189c0824e56966e21452936f23d
11 Nd9a777bcebb6462fabc60f2386ed60d3
12 anzsrc-for:06
13 anzsrc-for:0601
14 schema:author Nffcea0810ae441caadd1a4ed3aed5501
15 schema:citation sg:pub.10.1038/353576a0
16 https://doi.org/10.1016/0014-5793(84)81279-x
17 https://doi.org/10.1016/0014-5793(86)80908-5
18 https://doi.org/10.1016/0022-2836(91)80076-7
19 https://doi.org/10.1021/bi00449a001
20 https://doi.org/10.1056/nejm197501232920403
21 https://doi.org/10.1111/j.1432-1033.1975.tb02281.x
22 https://doi.org/10.1111/j.1432-1033.1990.tb19425.x
23 https://doi.org/10.1172/jci112731
24 https://doi.org/10.1172/jci113999
25 schema:datePublished 1992-06
26 schema:datePublishedReg 1992-06-01
27 schema:description Most northern Europeans have only the normal M form of the plasma protease inhibitor alpha 1-antitrypsin, but some 4% are heterozygotes for the Z deficiency variant. For reasons that have not been well-understood, the Z mutation results in a blockage in the final stage of processing of antitrypsin in the liver such that in the Z homozygote only 15% of the protein is secreted into the plasma. The 85% of the alpha 1-antitrypsin that is not secreted accumulates in the endoplasmic reticulum of the hepatocyte; much of it is degraded but the remainder aggregates to form insoluble intracellular inclusions. These inclusions are associated with hepatocellular damage, and 10% of newborn Z homozygotes develop liver disease which often leads to a fatal childhood cirrhosis. Here we demonstrate the molecular pathology underlying this accumulation and describe how the Z mutation in antitrypsin results in a unique molecular interaction between the reactive centre loop of one molecule and the gap in the A-sheet of another. This loop-sheet polymerization of Z antitrypsin occurs spontaneously at 37 degrees C and is completely blocked by the insertion of a specific peptide into the A-sheet of the antitrypsin molecule. Z antitrypsin polymerized in vitro has identical properties and ultrastructure to the inclusions isolated from hepatocytes of a Z homozygote. The concentration and temperature dependence of this loop-sheet polymerization has implications for the management of the liver disease of the newborn Z homozygote.
28 schema:genre research_article
29 schema:inLanguage en
30 schema:isAccessibleForFree false
31 schema:isPartOf N62c3e85227bb4a039a73e70976bc2f86
32 Nd1b539c1ceac490fa9ec5088481ecf8b
33 sg:journal.1018957
34 schema:name The mechanism of Z α1-antitrypsin accumulation in the liver
35 schema:pagination 605-607
36 schema:productId N77600d887f284d7abe430fcb6981dca9
37 N99a70f6052354b6886b9d9c0e3da7ffd
38 Nd5b35ba34f884efe88a191e3511ed930
39 Nde82b818872f4d61af4ade99fbffc385
40 Ne5a178c3f9af414dac62b7002011c056
41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048738506
42 https://doi.org/10.1038/357605a0
43 schema:sdDatePublished 2019-04-11T00:04
44 schema:sdLicense https://scigraph.springernature.com/explorer/license/
45 schema:sdPublisher N9458d45e43834222b0c6c58b09868249
46 schema:url http://www.nature.com/nature/journal/v357/n6379/full/357605a0.html
47 sgo:license sg:explorer/license/
48 sgo:sdDataset articles
49 rdf:type schema:ScholarlyArticle
50 N25924c13495c45bdb6a8604f460dd376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
51 schema:name Polymers
52 rdf:type schema:DefinedTerm
53 N3ae9b3a36ce546349e9330f5174094ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
54 schema:name Mutation
55 rdf:type schema:DefinedTerm
56 N5cc5fdadc37a40e1b432cb4d1a407e30 rdf:first sg:person.01151114516.83
57 rdf:rest rdf:nil
58 N62c3e85227bb4a039a73e70976bc2f86 schema:issueNumber 6379
59 rdf:type schema:PublicationIssue
60 N69fc2c78fb404215906f7c6e1eaf881d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Liver Diseases
62 rdf:type schema:DefinedTerm
63 N76a17cef44f14c1f850c263578a6f734 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name alpha 1-Antitrypsin
65 rdf:type schema:DefinedTerm
66 N77600d887f284d7abe430fcb6981dca9 schema:name dimensions_id
67 schema:value pub.1048738506
68 rdf:type schema:PropertyValue
69 N9458d45e43834222b0c6c58b09868249 schema:name Springer Nature - SN SciGraph project
70 rdf:type schema:Organization
71 N99a70f6052354b6886b9d9c0e3da7ffd schema:name doi
72 schema:value 10.1038/357605a0
73 rdf:type schema:PropertyValue
74 N9b685dc427d4439a8ec713d8414658b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Circular Dichroism
76 rdf:type schema:DefinedTerm
77 N9e2992b4eb604c719e8438e19552c92c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Macromolecular Substances
79 rdf:type schema:DefinedTerm
80 Na51cb90f3a4e4209a842db03b0cb1c04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Homozygote
82 rdf:type schema:DefinedTerm
83 Nb088a22bcdb94894935ca6745d434625 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Liver
85 rdf:type schema:DefinedTerm
86 Nbbc97b408e234b26b337b7ca31e3401c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Protein Conformation
88 rdf:type schema:DefinedTerm
89 Nbc2a39c247fe41358a7a51312fed0d9e rdf:first sg:person.01161220636.48
90 rdf:rest Nd7bd2bc53d054d458cb1f0db3707e603
91 Nd1b539c1ceac490fa9ec5088481ecf8b schema:volumeNumber 357
92 rdf:type schema:PublicationVolume
93 Nd3ca4189c0824e56966e21452936f23d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name alpha 1-Antitrypsin Deficiency
95 rdf:type schema:DefinedTerm
96 Nd5b35ba34f884efe88a191e3511ed930 schema:name nlm_unique_id
97 schema:value 0410462
98 rdf:type schema:PropertyValue
99 Nd7bd2bc53d054d458cb1f0db3707e603 rdf:first sg:person.01360454554.29
100 rdf:rest N5cc5fdadc37a40e1b432cb4d1a407e30
101 Nd9a777bcebb6462fabc60f2386ed60d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 Nde82b818872f4d61af4ade99fbffc385 schema:name readcube_id
105 schema:value e82e80eb4c3c22e1cee3cb3664bd402974bd6f565f279fd9bf9e7d0a72989395
106 rdf:type schema:PropertyValue
107 Ne5a178c3f9af414dac62b7002011c056 schema:name pubmed_id
108 schema:value 1608473
109 rdf:type schema:PropertyValue
110 Nffcea0810ae441caadd1a4ed3aed5501 rdf:first sg:person.01354415767.17
111 rdf:rest Nbc2a39c247fe41358a7a51312fed0d9e
112 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
113 schema:name Biological Sciences
114 rdf:type schema:DefinedTerm
115 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
116 schema:name Biochemistry and Cell Biology
117 rdf:type schema:DefinedTerm
118 sg:journal.1018957 schema:issn 0090-0028
119 1476-4687
120 schema:name Nature
121 rdf:type schema:Periodical
122 sg:person.01151114516.83 schema:familyName Carrell
123 schema:givenName R W
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151114516.83
125 rdf:type schema:Person
126 sg:person.01161220636.48 schema:familyName Evans
127 schema:givenName D L
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161220636.48
129 rdf:type schema:Person
130 sg:person.01354415767.17 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
131 schema:familyName Lomas
132 schema:givenName D A
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354415767.17
134 rdf:type schema:Person
135 sg:person.01360454554.29 schema:familyName Finch
136 schema:givenName J T
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360454554.29
138 rdf:type schema:Person
139 sg:pub.10.1038/353576a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031775725
140 https://doi.org/10.1038/353576a0
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1016/0014-5793(84)81279-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025591444
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1016/0014-5793(86)80908-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028442832
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1016/0022-2836(91)80076-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053191512
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1021/bi00449a001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055176679
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1056/nejm197501232920403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034101034
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1111/j.1432-1033.1975.tb02281.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028113473
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1111/j.1432-1033.1990.tb19425.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012286765
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1172/jci112731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017880552
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1172/jci113999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021040660
159 rdf:type schema:CreativeWork
160 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
161 schema:name Department of Haematology, University of Cambridge, UK.
162 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...