Functional contacts of a transfer RNA synthetase with 2′-hydroxyl groups in the RNA minor groove View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-06

AUTHORS

K Musier-Forsyth, P Schimmel

ABSTRACT

The functional analysis of determinants on RNA has been largely limited to molecules that contain naturally occurring ribonucleotides, so little is known about the role of 2'-hydroxyl groups in protein-RNA recognition. A single base pair (G3.U70) in the acceptor stem of tRNA(Ala) is the principal element for specific recognition by Escherichia coli alanine-tRNA synthetase. This tRNA synthetase aminoacylates small RNA helices that contain the G3.U70 base pair. Furthermore, removal of the G3 exocyclic 2-amino group that projects into the minor groove eliminates aminoacylation. This 2-amino group is flanked on either side by ribose 2'-hydroxyl groups that line the minor groove. Here we use chemical synthesis to construct 32 helices that make deoxy and O-methyl substitutions of individual and multiple 2'-hydroxyl groups near and beyond the G3.U70 base pair and find that functional 2'-hydroxyl contacts are clustered within a few ångstroms of the critical 2-amino group. These contacts are highly specific and make a thermodynamically significant contribution to RNA recognition. More... »

PAGES

513-515

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/357513a0

DOI

http://dx.doi.org/10.1038/357513a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045387090

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1608452


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