New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci View Full Text


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Article Info

DATE

1992-05

AUTHORS

David I. Watkins, Stephen N. McAdam, Xiaomin Liu, Clarice R. Strang, Edgar L. Milford, Cindy G. Levine, Theodore L. Garber, Alex L. Dogon, Carol I. Lord, Steven H. Ghim, Gary M. Troup, Austin L. Hughes, Norman L. Letvin

ABSTRACT

Evidence suggests that the New World was colonized only 11,000-40,000 years ago by Palaeo-Indians. The descendants of these Palaeo-Indians therefore provide a unique opportunity to study the effects of selection on major histocompatibility complex class I genes over a short period. Here we analyse the class I alleles of the Waorani of South America and the Zuni of North America. Four of the Waorani HLA-B alleles were new functional variants which could be accounted for by intralocus recombination. In contrast, all of the Zuni HLA-A and -B molecules were present in caucasians and orientals. This suggests that the new Waorani HLA-B variants arose in South America. The description of four new HLA-B alleles in the Waorani and another five new HLA-B alleles from two other tribes of South American Amerindians indicates that the HLA-B locus can evolve rapidly in isolated populations. These studies underline the importance of gathering genetic data on endangered native human populations. More... »

PAGES

329-333

References to SciGraph publications

  • 1992-05. Unusual HLA-B alleles in two tribes of Brazilian Indians in NATURE
  • 1987-05. Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: Evolutionary aspects in IMMUNOGENETICS
  • 1987-05. A transposable epitope of HLA-137, B40 molecules in IMMUNOGENETICS
  • 1991-08. Common West African HLA antigens are associated with protection from severe malaria in NATURE
  • 1991-11. Structure of the HLA-A*0204 antigen, found in South American Indians. Spatial clustering of HLA-A2 subtype polymorphism in IMMUNOGENETICS
  • 1988-09. HLA-A and B polymorphisms predate the divergence of humans and chimpanzees in NATURE
  • 1989-09. Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 in IMMUNOGENETICS
  • 1989-08. The structure ofHLA-B35 suggests that it is derived fromHLA-Bw58 by two genetic mechanisms in IMMUNOGENETICS
  • 1989-05. Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles in IMMUNOGENETICS
  • 1991-02. Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus) in IMMUNOGENETICS
  • 1992-03. Structure of the HLA-A*0211 (A2.5) subtype: further evidence for selection-driven diversification of HLA-A2 antigens in IMMUNOGENETICS
  • 1988-09. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection in NATURE
  • 1989-02. Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing in IMMUNOGENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/357329a0

    DOI

    http://dx.doi.org/10.1038/357329a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043654349

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1589035


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