Nuclear factor of activated T cells contains Fos and Jun View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-04

AUTHORS

Jugnu Jain, Patricia G. McCaffrey, Viia E. Valge-Archer, Anjana Rao

ABSTRACT

THE nuclear factor NF-AT (ref. 1) is induced in T cells stimulated through the T-cell receptor/CD3 complex, and is required for interleukin-2 (IL-2) gene induction. Although NF-AT has not been cloned or purified, there is evidence that it is a major target for immunosuppression by cyclosporin A (CsA) and FK506 (refs 2-7). NF-AT induction may require two activation-dependent events: the CsA-sensitive translocation of a pre-existing component and the CsA-resistant synthesis of a nuclear component8. Here we report that the newly synthesized nuclear component of NF-AT is the transcription factor AP-1. We show that the inducible nuclear form of NF-AT contains Fos and Jun proteins. Furthermore, we identify a pre-existing NF-AT-binding factor that is present in hypotonic extracts of unstimulated T cells. On the basis of binding, reconstitution and cotransfection experiments, we propose that activation of NF-AT occurs in at least two stages: a CsA-sensitive stage involving modification and/or translocation of the preexisting NF-AT complex, and a CsA-insensitive stage involving the addition of newly synthesized Fos or Fos/Jun proteins to the pre-existing complex. More... »

PAGES

801-804

Journal

TITLE

Nature

ISSUE

6372

VOLUME

356

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/356801a0

DOI

http://dx.doi.org/10.1038/356801a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002034612

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1533441


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