Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding View Full Text


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Article Info

DATE

1992-04

AUTHORS

T Langer, C Lu, H Echols, J Flanagan, M K Hayer, F U Hartl

ABSTRACT

The main stress proteins of Escherichia coli function in an ordered protein-folding reaction. DnaK (heat-shock protein 70) recognizes the folding polypeptide as an extended chain and cooperates with DnaJ in stabilizing an intermediate conformational state lacking ordered tertiary structure. Dependent on GrpE and ATP hydrolysis, the protein is then transferred to GroEL (heat-shock protein 60) which acts catalytically in the production of the native state. This sequential mechanism of chaperone action may represent an important pathway for the folding of newly synthesized polypeptides. More... »

PAGES

683-689

References to SciGraph publications

  • 1989-02. Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria in NATURE
  • 1988-11. Transient association of newly synthesized unfolded proteins with the heat-shock GroEL protein in NATURE
  • 1991-07. Unfolding protein folding in NATURE
  • 1988-05. Homologous plant and bacterial proteins chaperone oligomeric protein assembly in NATURE
  • 1978-05. The covalent and tertiary structure of bovine liver rhodanese in NATURE
  • 1989-01. GroE heat-shock proteins promote assembly of foreign prokaryotic ribulose bisphosphate carboxylase oligomers in Escherichia coli in NATURE
  • 1990-11. Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins in NATURE
  • 1987-07. Proteins as molecular chaperones in NATURE
  • 1988-04. 70K heat shock related proteins stimulate protein translocation into microsomes in NATURE
  • 1991-12. A molecular chaperone from a thermophilic archaebacterium is related to the eukaryotic protein t-complex polypeptide-1 in NATURE
  • 1991-04. The molten globule protein conformation probed by disulphide bonds in NATURE
  • 1989-02. Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor in NATURE
  • 1991-03. Function of DnaJ and DnaK as chaperones in origin-specific DNA binding by RepA in NATURE
  • 1989-09. Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis in NATURE
  • 1988-04. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides in NATURE
  • 1989-12. Reconstitution of active dimeric ribulose bisphosphate carboxylase from an unfolded state depends on two chaperonin proteins and Mg-ATP in NATURE
  • 1991-10. Peptide-binding specificity of the molecular chaperone BiP in NATURE
  • 1991-02. A homologue of the bacterial heat-shock gene DnaJ that alters protein sorting in yeast in NATURE
  • 1990-04. Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli in NATURE
  • 1992-01. Protein folding in the cell in NATURE
  • 1991-12. A cytoplasmic chaperonin? in NATURE
  • 1991-07. Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate in NATURE
  • 1988-04. Coming in from the cold in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/356683a0

    DOI

    http://dx.doi.org/10.1038/356683a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038057945

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1349157


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    RDF/XML is a standard XML format for linked data.

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