CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-04

AUTHORS

F A Harding, J G McArthur, J A Gross, D H Raulet, J P Allison

ABSTRACT

Occupancy of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. This requirement for two stimuli for T-cell activation could have an important role in vivo in establishing peripheral tolerance to antigens not encountered in the thymus. The receptor on T cells required for the co-stimulatory stimulus involved in the prevention of anergy has not been identified. The human T-cell antigen CD28 provides a signal that can synergize with T-cell antigen receptor stimulation in activating T cells to proliferate and secrete lymphokines. Here we report that a monoclonal antibody against the murine homologue of CD28 (ref. 7; J.A.G. et al., manuscript in preparation) can provide a co-stimulatory signal to naive CD4+ T cells and to T-cell clones. Moreover, we demonstrate that this co-stimulatory signal can block the induction of anergy in T-cell clones. More... »

PAGES

607-609

Journal

TITLE

Nature

ISSUE

6370

VOLUME

356

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/356607a0

    DOI

    http://dx.doi.org/10.1038/356607a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053474061

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1313950


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