Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-04

AUTHORS

H Büeler, M Fischer, Y Lang, H Bluethmann, H P Lipp, S J DeArmond, S B Prusiner, M Aguet, C Weissmann

ABSTRACT

PrPC is a host protein anchored to the outer surface of neurons and to a lesser extent of lymphocytes and other cells. The transmissible agent (prion) responsible for scrapie is believed to be a modified form of PrPC. Mice homozygous for disrupted PrP genes have been generated. Surprisingly, they develop and behave normally for at least seven months, and no immunological defects are apparent. It is now feasible to determine whether mice devoid of PrPC can propagate prions and are susceptible to scrapie pathogenesis. More... »

PAGES

577-582

Journal

TITLE

Nature

ISSUE

6370

VOLUME

356

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/356577a0

    DOI

    http://dx.doi.org/10.1038/356577a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026200779

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1373228


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