Caenorhabditis elegans gene ced-9 protects cells from programmed cell death View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-04

AUTHORS

M O Hengartner, R E Ellis, H R Horvitz

ABSTRACT

The gene ced-9 of the nematode Caenorhabditis elegans acts to protect cells from programmed cell death. A mutation that abnormally activates ced-9 prevents the cell deaths that occur during normal C. elegans development. Conversely, mutations that inactivate ced-9 cause cells that normally live to undergo programmed cell death; these mutations result in embryonic lethality, indicating that ced-9 function is essential for development. The ced-9 gene functions by negatively regulating the activities of other genes that are required for the process of programmed cell death. More... »

PAGES

494-499

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/356494a0

DOI

http://dx.doi.org/10.1038/356494a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020846616

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1560823


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