Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-03

AUTHORS

Rie Watanabe-Fukunaga, Camilynn I. Brannan, Neal G. Copeland, Nancy A. Jenkins, Shigekazu Nagata

ABSTRACT

Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumour necrosis factor receptor and nerve growth factor receptor. Mice carrying the lymphoprolifer-ation (Ipr) mutation have defects in the Fas antigen gene. The Ipr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus. More... »

PAGES

314-317

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6367

VOLUME

356

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/356314a0

    DOI

    http://dx.doi.org/10.1038/356314a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041635124

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1372394


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