Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-03

AUTHORS

R Watanabe-Fukunaga, C I Brannan, N G Copeland, N A Jenkins, S Nagata

ABSTRACT

Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumour necrosis factor receptor and nerve growth factor receptor. Mice carrying the lymphoproliferation (lpr) mutation have defects in the Fas antigen gene. The lpr mice develop lymphadenopathy and suffer from a systemic lupus erythematosus-like autoimmune disease, indicating an important role for Fas antigen in the negative selection of autoreactive T cells in the thymus. More... »

PAGES

314-317

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6367

VOLUME

356

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/356314a0

    DOI

    http://dx.doi.org/10.1038/356314a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041635124

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1372394


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