Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-03

AUTHORS

L A Donehower, M Harvey, B L Slagle, M J McArthur, C A Montgomery, J S Butel, A Bradley

ABSTRACT

Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of neoplasms by 6 months of age. These observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours. More... »

PAGES

215-221

Journal

TITLE

Nature

ISSUE

6366

VOLUME

356

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/356215a0

    DOI

    http://dx.doi.org/10.1038/356215a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027559823

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1552940


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