Genetic immunization is a simple method for eliciting an immune response View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-03

AUTHORS

D C Tang, M DeVit, S A Johnston

ABSTRACT

To produce an immune reaction against a foreign protein usually requires purification of that protein, which is then injected into an animal. The isolation of enough pure protein is time-consuming and sometimes difficult. Here we report that such a response can also be elicited by introducing the gene encoding a protein directly into the skin of mice. This is achieved using a hand-held form of the biolistic system which can propel DNA-coated gold microprojectiles directly into cells in the living animal. Genetic immunization may be time- and labour-saving in producing antibodies and may offer a unique method for vaccination. More... »

PAGES

152-154

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6365

VOLUME

356

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/356152a0

    DOI

    http://dx.doi.org/10.1038/356152a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023052619

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1545867


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