A chloride channel widely expressed in epithelial and non-epithelial cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-03

AUTHORS

A Thiemann, S Gründer, M Pusch, T J Jentsch

ABSTRACT

Chloride channels have several functions, including the regulation of cell volume, stabilizing membrane potential, signal transduction and transepithelial transport. The plasma membrane Cl- channels already cloned belong to different structural classes: ligand-gated channels, voltage-gated channels, and possibly transporters of the ATP-binding-cassette type (if the cystic fibrosis transmembrane regulator is a Cl- channel). The importance of chloride channels is illustrated by the phenotypes that can result from their malfunction: cystic fibrosis, in which transepithelial transport is impaired, and myotonia, in which ClC-1, the principal skeletal muscle Cl- channel, is defective. Here we report the properties of ClC-2, a new member of the voltage-gated Cl- channel family. Its sequence is approximately 50% identical to either the Torpedo electroplax Cl- channel, ClC-0 (ref. 8), or the rat muscle Cl- channel, ClC-1 (ref. 9). Isolated initially from rat heart and brain, it is also expressed in pancreas, lung and liver, for example, and in pure cell lines of fibroblastic, neuronal, and epithelial origin, including tissues and cells affected by cystic fibrosis. Expression in Xenopus oocytes induces Cl- currents that activate slowly upon hyperpolarization and display a linear instantaneous current-voltage relationship. The conductivity sequence is Cl- greater than or equal to Br- greater than I-. The presence of ClC-2 in such different cell types contrasts with the highly specialized expression of ClC-1 (ref. 9) and also with the cloned cation channels, and suggests that its function is important for most cells. More... »

PAGES

57-60

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/356057a0

DOI

http://dx.doi.org/10.1038/356057a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012327154

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1311421


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Northern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chloride Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chlorides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electric Conductivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Hamburg", 
          "id": "https://www.grid.ac/institutes/grid.9026.d", 
          "name": [
            "Centre for Molecular Neurobiology (ZMNH), Hamburg University, Hamburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thiemann", 
        "givenName": "A", 
        "id": "sg:person.01204520554.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204520554.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gr\u00fcnder", 
        "givenName": "S", 
        "id": "sg:person.01327276071.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327276071.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Pusch", 
        "givenName": "M", 
        "id": "sg:person.01012610302.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012610302.93"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Jentsch", 
        "givenName": "T J", 
        "id": "sg:person.0762575470.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762575470.13"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1992-03", 
    "datePublishedReg": "1992-03-01", 
    "description": "Chloride channels have several functions, including the regulation of cell volume, stabilizing membrane potential, signal transduction and transepithelial transport. The plasma membrane Cl- channels already cloned belong to different structural classes: ligand-gated channels, voltage-gated channels, and possibly transporters of the ATP-binding-cassette type (if the cystic fibrosis transmembrane regulator is a Cl- channel). The importance of chloride channels is illustrated by the phenotypes that can result from their malfunction: cystic fibrosis, in which transepithelial transport is impaired, and myotonia, in which ClC-1, the principal skeletal muscle Cl- channel, is defective. Here we report the properties of ClC-2, a new member of the voltage-gated Cl- channel family. Its sequence is approximately 50% identical to either the Torpedo electroplax Cl- channel, ClC-0 (ref. 8), or the rat muscle Cl- channel, ClC-1 (ref. 9). Isolated initially from rat heart and brain, it is also expressed in pancreas, lung and liver, for example, and in pure cell lines of fibroblastic, neuronal, and epithelial origin, including tissues and cells affected by cystic fibrosis. Expression in Xenopus oocytes induces Cl- currents that activate slowly upon hyperpolarization and display a linear instantaneous current-voltage relationship. The conductivity sequence is Cl- greater than or equal to Br- greater than I-. The presence of ClC-2 in such different cell types contrasts with the highly specialized expression of ClC-1 (ref. 9) and also with the cloned cation channels, and suggests that its function is important for most cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/356057a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6364", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "356"
      }
    ], 
    "name": "A chloride channel widely expressed in epithelial and non-epithelial cells", 
    "pagination": "57-60", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3abadf1a905e8a4feba853a35d92f94731780909f7ac1d72e59ac54951668458"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1311421"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/356057a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012327154"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/356057a0", 
      "https://app.dimensions.ai/details/publication/pub.1012327154"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nature/journal/v356/n6364/full/356057a0.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/356057a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/356057a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/356057a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/356057a0'


 

This table displays all metadata directly associated to this object as RDF triples.

139 TRIPLES      20 PREDICATES      42 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/356057a0 schema:about N1f650524aaa74e95b10aa3ecf2c8ef5a
2 N4a4781c92fc14c4388b9b3e447748126
3 N4ef04498cbe0440cb221c30e811e1568
4 N5c53276352ba42dda2a0cb55ecc84a8d
5 N778d2befba934892bc6f432770fe4115
6 N7f3ec4a272174900802cbc7485f1f8f8
7 Naecd691bda5d485ca1cb7e7eb3723126
8 Nb7284ff886134f84b153d77e47b4e8a8
9 Ndbc085c39e614d4fb07a984f4180bcc9
10 Ne031fa7301724d448226db383b37230e
11 Neb4ff721671d4c8ebe02ed751d88f23f
12 Nef426040b95e406ca3fdd46c381c064b
13 Nf7809586a60845f8b34be62ac7a40cf5
14 anzsrc-for:06
15 anzsrc-for:0601
16 schema:author N8eb6fb680a36461f91d6abbc4a32bc38
17 schema:datePublished 1992-03
18 schema:datePublishedReg 1992-03-01
19 schema:description Chloride channels have several functions, including the regulation of cell volume, stabilizing membrane potential, signal transduction and transepithelial transport. The plasma membrane Cl- channels already cloned belong to different structural classes: ligand-gated channels, voltage-gated channels, and possibly transporters of the ATP-binding-cassette type (if the cystic fibrosis transmembrane regulator is a Cl- channel). The importance of chloride channels is illustrated by the phenotypes that can result from their malfunction: cystic fibrosis, in which transepithelial transport is impaired, and myotonia, in which ClC-1, the principal skeletal muscle Cl- channel, is defective. Here we report the properties of ClC-2, a new member of the voltage-gated Cl- channel family. Its sequence is approximately 50% identical to either the Torpedo electroplax Cl- channel, ClC-0 (ref. 8), or the rat muscle Cl- channel, ClC-1 (ref. 9). Isolated initially from rat heart and brain, it is also expressed in pancreas, lung and liver, for example, and in pure cell lines of fibroblastic, neuronal, and epithelial origin, including tissues and cells affected by cystic fibrosis. Expression in Xenopus oocytes induces Cl- currents that activate slowly upon hyperpolarization and display a linear instantaneous current-voltage relationship. The conductivity sequence is Cl- greater than or equal to Br- greater than I-. The presence of ClC-2 in such different cell types contrasts with the highly specialized expression of ClC-1 (ref. 9) and also with the cloned cation channels, and suggests that its function is important for most cells.
20 schema:genre research_article
21 schema:inLanguage en
22 schema:isAccessibleForFree false
23 schema:isPartOf N400384e3bee6487083911da00c75eff9
24 Nbfdcd6b0c6ea40b39eec28b18fde1889
25 sg:journal.1018957
26 schema:name A chloride channel widely expressed in epithelial and non-epithelial cells
27 schema:pagination 57-60
28 schema:productId N6576c35833f440d59e99a731a9df20bb
29 N6c30910575ef45e89dc80015d4e97d12
30 N76f0edcf2e684da0ba0a79c1a9840cec
31 N7efba430a4b3445eb9440fc0f4cfd1a5
32 N9a73165f9fe84556a8c9240e46390830
33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012327154
34 https://doi.org/10.1038/356057a0
35 schema:sdDatePublished 2019-04-10T14:47
36 schema:sdLicense https://scigraph.springernature.com/explorer/license/
37 schema:sdPublisher Nb600b68ce0434643854f30f32a85a6ff
38 schema:url http://www.nature.com/nature/journal/v356/n6364/full/356057a0.html
39 sgo:license sg:explorer/license/
40 sgo:sdDataset articles
41 rdf:type schema:ScholarlyArticle
42 N03a2ae59cad14f958dda1fe984adc861 rdf:first sg:person.01327276071.09
43 rdf:rest N5e8ee144b5934282962ab2c778fc067c
44 N1f650524aaa74e95b10aa3ecf2c8ef5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
45 schema:name Humans
46 rdf:type schema:DefinedTerm
47 N3d90a6e584294f3089faf018d03dfe4a rdf:first sg:person.0762575470.13
48 rdf:rest rdf:nil
49 N400384e3bee6487083911da00c75eff9 schema:volumeNumber 356
50 rdf:type schema:PublicationVolume
51 N4a4781c92fc14c4388b9b3e447748126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
52 schema:name Blotting, Northern
53 rdf:type schema:DefinedTerm
54 N4ef04498cbe0440cb221c30e811e1568 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
55 schema:name Membrane Proteins
56 rdf:type schema:DefinedTerm
57 N5c53276352ba42dda2a0cb55ecc84a8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
58 schema:name Nerve Tissue Proteins
59 rdf:type schema:DefinedTerm
60 N5e8ee144b5934282962ab2c778fc067c rdf:first sg:person.01012610302.93
61 rdf:rest N3d90a6e584294f3089faf018d03dfe4a
62 N6576c35833f440d59e99a731a9df20bb schema:name readcube_id
63 schema:value 3abadf1a905e8a4feba853a35d92f94731780909f7ac1d72e59ac54951668458
64 rdf:type schema:PropertyValue
65 N6c30910575ef45e89dc80015d4e97d12 schema:name doi
66 schema:value 10.1038/356057a0
67 rdf:type schema:PropertyValue
68 N76f0edcf2e684da0ba0a79c1a9840cec schema:name dimensions_id
69 schema:value pub.1012327154
70 rdf:type schema:PropertyValue
71 N778d2befba934892bc6f432770fe4115 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Molecular Sequence Data
73 rdf:type schema:DefinedTerm
74 N7efba430a4b3445eb9440fc0f4cfd1a5 schema:name pubmed_id
75 schema:value 1311421
76 rdf:type schema:PropertyValue
77 N7f3ec4a272174900802cbc7485f1f8f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Animals
79 rdf:type schema:DefinedTerm
80 N8eb6fb680a36461f91d6abbc4a32bc38 rdf:first sg:person.01204520554.25
81 rdf:rest N03a2ae59cad14f958dda1fe984adc861
82 N9a73165f9fe84556a8c9240e46390830 schema:name nlm_unique_id
83 schema:value 0410462
84 rdf:type schema:PropertyValue
85 Naecd691bda5d485ca1cb7e7eb3723126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Amino Acid Sequence
87 rdf:type schema:DefinedTerm
88 Nb600b68ce0434643854f30f32a85a6ff schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 Nb7284ff886134f84b153d77e47b4e8a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Electric Conductivity
92 rdf:type schema:DefinedTerm
93 Nbfdcd6b0c6ea40b39eec28b18fde1889 schema:issueNumber 6364
94 rdf:type schema:PublicationIssue
95 Ndbc085c39e614d4fb07a984f4180bcc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Chlorides
97 rdf:type schema:DefinedTerm
98 Ne031fa7301724d448226db383b37230e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Cell Line
100 rdf:type schema:DefinedTerm
101 Neb4ff721671d4c8ebe02ed751d88f23f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Rats
103 rdf:type schema:DefinedTerm
104 Nef426040b95e406ca3fdd46c381c064b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Base Sequence
106 rdf:type schema:DefinedTerm
107 Nf7809586a60845f8b34be62ac7a40cf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Chloride Channels
109 rdf:type schema:DefinedTerm
110 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
111 schema:name Biological Sciences
112 rdf:type schema:DefinedTerm
113 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
114 schema:name Biochemistry and Cell Biology
115 rdf:type schema:DefinedTerm
116 sg:journal.1018957 schema:issn 0090-0028
117 1476-4687
118 schema:name Nature
119 rdf:type schema:Periodical
120 sg:person.01012610302.93 schema:familyName Pusch
121 schema:givenName M
122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012610302.93
123 rdf:type schema:Person
124 sg:person.01204520554.25 schema:affiliation https://www.grid.ac/institutes/grid.9026.d
125 schema:familyName Thiemann
126 schema:givenName A
127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204520554.25
128 rdf:type schema:Person
129 sg:person.01327276071.09 schema:familyName Gründer
130 schema:givenName S
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327276071.09
132 rdf:type schema:Person
133 sg:person.0762575470.13 schema:familyName Jentsch
134 schema:givenName T J
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762575470.13
136 rdf:type schema:Person
137 https://www.grid.ac/institutes/grid.9026.d schema:alternateName University of Hamburg
138 schema:name Centre for Molecular Neurobiology (ZMNH), Hamburg University, Hamburg, Germany.
139 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...