Ham-2 corrects the class I antigen-processing defect in RMA-S cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-02

AUTHORS

M Attaya, S Jameson, C K Martinez, E Hermel, C Aldrich, J Forman, K F Lindahl, M J Bevan, J J Monaco

ABSTRACT

The murine major histocompatibility complex (MHC) contains two genes (Ham-1 and Ham-2) that encode members of a super-family of ATP-dependent transport proteins. These genes are believed to mediate the transport of peptide antigen from the cytoplasm into the lumen of the endoplasmic reticulum for binding by MHC class I molecules. Evidence for such a function has come from the rescue of class I surface expression by a cloned copy of the human homologue of Ham-1, PSF-1, in a human cell line that is defective in antigen processing. A mutant murine cell line, RMA-S, has an identical antigen-processing-defective phenotype. Here we show that expression of a cloned copy of the Ham-2 gene in RMA-S cells results in recovery of the ability to process and present class I-restricted antigens to cytotoxic T lymphocytes, and in partial recovery of class I surface expression. Processing defects for classical (H-2 K and D) and non-classical (Qa1 and HMT) class I molecules are corrected by Ham-2. These data indicate that both MHC-linked transporter genes are probably required for class I antigen processing, and that the functional transporter in this pathway may consist of a Ham-1/Ham-2 heterodimer. More... »

PAGES

647-649

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/355647a0

DOI

http://dx.doi.org/10.1038/355647a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015048357

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1538753


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