Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-01

AUTHORS

S A Kliewer, K Umesono, D J Mangelsdorf, R M Evans

ABSTRACT

Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the retinoic acid receptors (RAR) and the retinoid X receptors (RXR). Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins. RAR and RXR have a high degree of cooperativity in binding to target DNA, consistent with previous reports indicating that the binding of either RAR or RXR to their cognate response elements is enhanced by factors present in nuclear extracts. RXR also interacts directly with and enhances the binding of nuclear receptors conferring responsiveness to vitamin D3 and thyroid hormone T3; the DNA-binding activities of these receptors are also stimulated by the presence of nuclear extracts. Together these data indicate that RXR has a central role in multiple hormonal signalling pathways. More... »

PAGES

446-449

Journal

TITLE

Nature

ISSUE

6359

VOLUME

355

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/355446a0

    DOI

    http://dx.doi.org/10.1038/355446a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001167241

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1310351


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