Viral envelope fails to deliver? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-02

AUTHORS

Dani P. Bolognesi, Thomas J. Matthews

ABSTRACT

Clinical trials of vaccines against the human immunodeficiency virus are underway, but initial results do not seem promising — at least for one type of vaccine. By injecting patients with a recombinant form of a viral envelope protein, gp120, the idea was to induce an antibody response that could fight subsequent infection with the virus. But in a trial of 18 people, all became infected with HIV-1 and, at the level of the immune system, those who had received the vaccine did not seem to deal with the infection any differently than unvaccinated patients. More... »

PAGES

638-639

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35504

DOI

http://dx.doi.org/10.1038/35504

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045715446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9490406


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AIDS Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials, Phase I as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials, Phase II as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Envelope Protein gp120", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes, Cytotoxic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thailand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines, Synthetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Dani P. Bolognesi and Thomas J. Matthews are in the Department of Surgery, Duke University Medical Center, PO Box 2926, 27710, Durham, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Dani P. Bolognesi and Thomas J. Matthews are in the Department of Surgery, Duke University Medical Center, PO Box 2926, 27710, Durham, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bolognesi", 
        "givenName": "Dani P.", 
        "id": "sg:person.0667101613.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667101613.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dani P. Bolognesi and Thomas J. Matthews are in the Department of Surgery, Duke University Medical Center, PO Box 2926, 27710, Durham, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Dani P. Bolognesi and Thomas J. Matthews are in the Department of Surgery, Duke University Medical Center, PO Box 2926, 27710, Durham, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matthews", 
        "givenName": "Thomas J.", 
        "id": "sg:person.010625377572.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010625377572.00"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1998-02", 
    "datePublishedReg": "1998-02-01", 
    "description": "Clinical trials of vaccines against the human immunodeficiency virus are underway, but initial results do not seem promising \u2014 at least for one type of vaccine. By injecting patients with a recombinant form of a viral envelope protein, gp120, the idea was to induce an antibody response that could fight subsequent infection with the virus. But in a trial of 18 people, all became infected with HIV-1 and, at the level of the immune system, those who had received the vaccine did not seem to deal with the infection any differently than unvaccinated patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/35504", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6668", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "391"
      }
    ], 
    "keywords": [
      "human immunodeficiency virus", 
      "type of vaccine", 
      "unvaccinated patients", 
      "immunodeficiency virus", 
      "antibody response", 
      "clinical trials", 
      "HIV-1", 
      "viral envelope proteins", 
      "subsequent infection", 
      "immune system", 
      "vaccine", 
      "patients", 
      "envelope protein", 
      "infection", 
      "viral envelope", 
      "trials", 
      "recombinant form", 
      "virus", 
      "gp120", 
      "initial results", 
      "response", 
      "levels", 
      "protein", 
      "people", 
      "types", 
      "results", 
      "form", 
      "envelope", 
      "system", 
      "idea"
    ], 
    "name": "Viral envelope fails to deliver?", 
    "pagination": "638-639", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045715446"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/35504"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9490406"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/35504", 
      "https://app.dimensions.ai/details/publication/pub.1045715446"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_276.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/35504"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35504'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35504'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35504'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35504'


 

This table displays all metadata directly associated to this object as RDF triples.

150 TRIPLES      20 PREDICATES      69 URIs      60 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/35504 schema:about N041afbd92a464f4fb40c8a3dd353c3f5
2 N0e1c62af828044c1b175aa81d30d7099
3 N27b9dc6c50174a4682bfaf54f03d5de3
4 N2acb918b8e324901b280d5baac6e4181
5 N3f7e6d4108044e83a128f64c18e9ec25
6 N929122cf77694b88b65cf964413acf32
7 Nb76d66a35e2e4a249203e466297c954c
8 Nc3d556258b3c4051902d49b4e29555a8
9 Nc420204da21c41cbb70f814686faf6f8
10 Nd93a679caa984985a4153b58757a0fa2
11 Nddb04a3b7b6a4521a58aec0b1b80fe46
12 Nf24e131292ed4d30a66494b6a6b70540
13 anzsrc-for:11
14 anzsrc-for:1107
15 anzsrc-for:1108
16 schema:author Ne56258c1ad5b4ab3be53ba9c6968f1ef
17 schema:datePublished 1998-02
18 schema:datePublishedReg 1998-02-01
19 schema:description Clinical trials of vaccines against the human immunodeficiency virus are underway, but initial results do not seem promising — at least for one type of vaccine. By injecting patients with a recombinant form of a viral envelope protein, gp120, the idea was to induce an antibody response that could fight subsequent infection with the virus. But in a trial of 18 people, all became infected with HIV-1 and, at the level of the immune system, those who had received the vaccine did not seem to deal with the infection any differently than unvaccinated patients.
20 schema:genre article
21 schema:isAccessibleForFree true
22 schema:isPartOf N27066edcdccf4e89a32095d83e74ab62
23 N386faab4a0c9495e8eeac3e785fcbad3
24 sg:journal.1018957
25 schema:keywords HIV-1
26 antibody response
27 clinical trials
28 envelope
29 envelope protein
30 form
31 gp120
32 human immunodeficiency virus
33 idea
34 immune system
35 immunodeficiency virus
36 infection
37 initial results
38 levels
39 patients
40 people
41 protein
42 recombinant form
43 response
44 results
45 subsequent infection
46 system
47 trials
48 type of vaccine
49 types
50 unvaccinated patients
51 vaccine
52 viral envelope
53 viral envelope proteins
54 virus
55 schema:name Viral envelope fails to deliver?
56 schema:pagination 638-639
57 schema:productId N61d435683daf4a0583d4c000a980a37b
58 N6d74e01a367a45f0b5d2e80953aed307
59 N748000e395b34268a78b7e617e320f51
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045715446
61 https://doi.org/10.1038/35504
62 schema:sdDatePublished 2022-01-01T18:07
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N71fa099b1bb1414aa0aa3d3807b706a2
65 schema:url https://doi.org/10.1038/35504
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N041afbd92a464f4fb40c8a3dd353c3f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Clinical Trials, Phase II as Topic
71 rdf:type schema:DefinedTerm
72 N0e1c62af828044c1b175aa81d30d7099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name HIV Antibodies
74 rdf:type schema:DefinedTerm
75 N27066edcdccf4e89a32095d83e74ab62 schema:issueNumber 6668
76 rdf:type schema:PublicationIssue
77 N27b9dc6c50174a4682bfaf54f03d5de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Humans
79 rdf:type schema:DefinedTerm
80 N2acb918b8e324901b280d5baac6e4181 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name HIV
82 rdf:type schema:DefinedTerm
83 N386faab4a0c9495e8eeac3e785fcbad3 schema:volumeNumber 391
84 rdf:type schema:PublicationVolume
85 N3f7e6d4108044e83a128f64c18e9ec25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Vaccines, Synthetic
87 rdf:type schema:DefinedTerm
88 N520f15970a384e2e82dc371b6e62238c rdf:first sg:person.010625377572.00
89 rdf:rest rdf:nil
90 N61d435683daf4a0583d4c000a980a37b schema:name dimensions_id
91 schema:value pub.1045715446
92 rdf:type schema:PropertyValue
93 N6d74e01a367a45f0b5d2e80953aed307 schema:name pubmed_id
94 schema:value 9490406
95 rdf:type schema:PropertyValue
96 N71fa099b1bb1414aa0aa3d3807b706a2 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N748000e395b34268a78b7e617e320f51 schema:name doi
99 schema:value 10.1038/35504
100 rdf:type schema:PropertyValue
101 N929122cf77694b88b65cf964413acf32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name United States
103 rdf:type schema:DefinedTerm
104 Nb76d66a35e2e4a249203e466297c954c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Thailand
106 rdf:type schema:DefinedTerm
107 Nc3d556258b3c4051902d49b4e29555a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name HIV Envelope Protein gp120
109 rdf:type schema:DefinedTerm
110 Nc420204da21c41cbb70f814686faf6f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name HIV Infections
112 rdf:type schema:DefinedTerm
113 Nd93a679caa984985a4153b58757a0fa2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name T-Lymphocytes, Cytotoxic
115 rdf:type schema:DefinedTerm
116 Nddb04a3b7b6a4521a58aec0b1b80fe46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Clinical Trials, Phase I as Topic
118 rdf:type schema:DefinedTerm
119 Ne56258c1ad5b4ab3be53ba9c6968f1ef rdf:first sg:person.0667101613.62
120 rdf:rest N520f15970a384e2e82dc371b6e62238c
121 Nf24e131292ed4d30a66494b6a6b70540 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name AIDS Vaccines
123 rdf:type schema:DefinedTerm
124 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
125 schema:name Medical and Health Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
128 schema:name Immunology
129 rdf:type schema:DefinedTerm
130 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
131 schema:name Medical Microbiology
132 rdf:type schema:DefinedTerm
133 sg:journal.1018957 schema:issn 0028-0836
134 1476-4687
135 schema:name Nature
136 schema:publisher Springer Nature
137 rdf:type schema:Periodical
138 sg:person.010625377572.00 schema:affiliation grid-institutes:grid.189509.c
139 schema:familyName Matthews
140 schema:givenName Thomas J.
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010625377572.00
142 rdf:type schema:Person
143 sg:person.0667101613.62 schema:affiliation grid-institutes:grid.189509.c
144 schema:familyName Bolognesi
145 schema:givenName Dani P.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667101613.62
147 rdf:type schema:Person
148 grid-institutes:grid.189509.c schema:alternateName Dani P. Bolognesi and Thomas J. Matthews are in the Department of Surgery, Duke University Medical Center, PO Box 2926, 27710, Durham, North Carolina, USA
149 schema:name Dani P. Bolognesi and Thomas J. Matthews are in the Department of Surgery, Duke University Medical Center, PO Box 2926, 27710, Durham, North Carolina, USA
150 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...