Ontology type: schema:ScholarlyArticle
1991-12
AUTHORSMichael Gregory Peterson, Juan Inostroza, Mary E. Maxon, Osvaldo Flores, Arie Admon, Danny Reinberg, Robert Tjian
ABSTRACTThe general transcription factor HE (TFIIE) is an essential component of the eukaryotic RNA poly-merase II initiation complex. We have isolated human complementary DNA clones for both the subunits of TFIIE. Using purified recombinant proteins we find that both subunits are essential to form a stable preinitiation complex and to reconstitute basal-level and Sp1-activated transcription in vitro. Analysis of their predicted amino-acid sequences reveals several intriguing structural motifs that could provide insight into the role of TFIIE in transcription initiation. More... »
PAGES369-373
http://scigraph.springernature.com/pub.10.1038/354369a0
DOIhttp://dx.doi.org/10.1038/354369a0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/1956398
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