Electrically credible polymer gel for controlled release of drugs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-11

AUTHORS

I C Kwon, Y H Bae, S W Kim

ABSTRACT

New controlled drug-delivery systems are being explored to overcome the disadvantages of conventional dosage forms. For example, stimulated drug-delivery has been used to overcome the tolerance problems that occur with a constant delivery rate, to mimic the physiological pattern of hormonal concentration and to supply drugs on demand. Stimuli-sensitive polymers, which are potentially useful for pulsed drug delivery, experience changes in either their structure or their chemical properties in response to changes in environmental conditions. Environmental stimuli include temperature, pH, light (ultraviolet or visible), electric field or certain chemicals. Volume changes of stimuli-sensitive gel networks are particularly responsive to external stimuli, but swelling is slow to occur. As well as being useful in the controlled release of drugs, such systems also provide insight into intermolecular interactions. Here we report on a novel polymeric system, which rapidly changes from a solid state to solution in response to small electric currents, by disintegration of the solid polymer complex into two water-soluble polymers. We show that the modulated release of insulin, and by extension other macromolecules, can be achieved with this polymeric system. More... »

PAGES

291-293

Journal

TITLE

Nature

ISSUE

6351

VOLUME

354

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/354291a0

    DOI

    http://dx.doi.org/10.1038/354291a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036916751

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1956379


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