An African HIV-1 sequence from 1959 and implications for the origin of the epidemic View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-02

AUTHORS

Tuofu Zhu, Bette T. Korber, Andre J. Nahmias, Edward Hooper, Paul M. Sharp, David D. Ho

ABSTRACT

There is considerable genetic diversity among viruses of different subtypes (designated A to J) in the major group of human immunodeficiency virus type 1 (HIV-1), the form of HIV that is dominant in the global epidemic. If available, HIV-1 sequences pre-dating the recognition of AIDS could be crucial in defining the time of origin and the subsequent evolution of these viruses in humans. The oldest known case of HIV-1 infection was reported to be that of a sailor from Manchester who died of an AIDS-like illness in 1959; however, the authenticity of this case has not been confirmed. Genetic analysis of sequences from clinical materials obtained from 1971 to 1976 from members of a Norwegian family infected earlier than 1971 showed that they carried viruses of the HIV-1 outlier group, a variant form that is mainly restricted to West Africa. Here we report the amplification and characterization of viral sequences from a 1959 African plasma sample that was previously found to be HIV-1 seropositive. Multiple phylogenetic analyses not only authenticate this case as the oldest known HIV-1 infection, but also place its viral sequence near the ancestral node of subtypes B and D in the major group, indicating that these HIV-1 subtypes, and perhaps all major-group viruses, may have evolved from a single introduction into the African population not long before 1959. More... »

PAGES

594-597

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35400

DOI

http://dx.doi.org/10.1038/35400

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023244491

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9468138


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Democratic Republic of the Congo", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Outbreaks", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "History, 20th Century", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeny", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Alignment", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Rockefeller University", 
          "id": "https://www.grid.ac/institutes/grid.134907.8", 
          "name": [
            "*Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Tuofu", 
        "id": "sg:person.0630363256.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630363256.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Santa Fe Institute", 
          "id": "https://www.grid.ac/institutes/grid.209665.e", 
          "name": [
            "\u2021Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA", 
            "\u00a7The Santa Fe Institute, Santa Fe, New Mexico 87501, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korber", 
        "givenName": "Bette T.", 
        "id": "sg:person.01237531654.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237531654.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "\u2016Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30303, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nahmias", 
        "givenName": "Andre J.", 
        "id": "sg:person.0100237752.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100237752.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "\u00b6PO Box 4087, Worthing BN14 7LQ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hooper", 
        "givenName": "Edward", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "#Department of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharp", 
        "givenName": "Paul M.", 
        "id": "sg:person.011734705062.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011734705062.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rockefeller University", 
          "id": "https://www.grid.ac/institutes/grid.134907.8", 
          "name": [
            "*Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ho", 
        "givenName": "David D.", 
        "id": "sg:person.01342202624.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342202624.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.87.11.4108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000773771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/333573a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006062861", 
          "https://doi.org/10.1038/333573a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199001001-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006959374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199001001-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006959374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199001001-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006959374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(86)91422-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007148169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(86)91422-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007148169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)92164-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010732129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(96)07063-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013566630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(05)80360-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013618994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199306000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014586986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002030-199306000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014586986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/374503a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026329685", 
          "https://doi.org/10.1038/374503a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02100115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026773907", 
          "https://doi.org/10.1007/bf02100115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02100115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026773907", 
          "https://doi.org/10.1007/bf02100115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(83)90644-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028750122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(60)92026-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034809857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(60)92026-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034809857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(88)90129-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042259073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(88)90129-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042259073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01734359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044065382", 
          "https://doi.org/10.1007/bf01734359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01734359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044065382", 
          "https://doi.org/10.1007/bf01734359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.20.10864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046563271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.1997.8510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048761115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91561-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049421013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)91561-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049421013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/336315a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050092899", 
          "https://doi.org/10.1038/336315a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/374124b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052214377", 
          "https://doi.org/10.1038/374124b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0016672300032481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054035055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0016672300032481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054035055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1995.11.1413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059224054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/10.1.41", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059413334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5261.537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.molbev.a040503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079727097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080999772", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082375719", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082884631", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083089730", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998-02", 
    "datePublishedReg": "1998-02-01", 
    "description": "There is considerable genetic diversity among viruses of different subtypes (designated A to J) in the major group of human immunodeficiency virus type 1 (HIV-1), the form of HIV that is dominant in the global epidemic. If available, HIV-1 sequences pre-dating the recognition of AIDS could be crucial in defining the time of origin and the subsequent evolution of these viruses in humans. The oldest known case of HIV-1 infection was reported to be that of a sailor from Manchester who died of an AIDS-like illness in 1959; however, the authenticity of this case has not been confirmed. Genetic analysis of sequences from clinical materials obtained from 1971 to 1976 from members of a Norwegian family infected earlier than 1971 showed that they carried viruses of the HIV-1 outlier group, a variant form that is mainly restricted to West Africa. Here we report the amplification and characterization of viral sequences from a 1959 African plasma sample that was previously found to be HIV-1 seropositive. Multiple phylogenetic analyses not only authenticate this case as the oldest known HIV-1 infection, but also place its viral sequence near the ancestral node of subtypes B and D in the major group, indicating that these HIV-1 subtypes, and perhaps all major-group viruses, may have evolved from a single introduction into the African population not long before 1959.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/35400", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6667", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "391"
      }
    ], 
    "name": "An African HIV-1 sequence from 1959 and implications for the origin of the epidemic", 
    "pagination": "594-597", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6ebdea3577596412bfdec91b248237c0f373d3ca195c049d47a341eacd552635"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9468138"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/35400"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023244491"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/35400", 
      "https://app.dimensions.ai/details/publication/pub.1023244491"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53987_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/35400"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/35400'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/35400'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/35400'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/35400'


 

This table displays all metadata directly associated to this object as RDF triples.

252 TRIPLES      21 PREDICATES      70 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/35400 schema:about N17e035ada07643edaa38fadb60d69909
2 N1878fd8ed1dc4af5a312a0acf0cef6d8
3 N27b046702702437ca6e717d9a2872ae7
4 N3eaa8e321c7141fc80d13a9036f5b37e
5 N43b6939c02f149b791a71de474dde7c3
6 N7675c2bf8d0f43dcb8e350439f530977
7 N85481099b4b647668826e82e53451a2d
8 N867b34e9050e4071a718d8357459b360
9 N953d30f12db34f698f3b8db4d2a64ac6
10 N9b20cc44178944a3b03041c1618ddd9c
11 Nb988e50e3f1c4ad1b4e4508e5051e9b6
12 Nd1c7d8913ed04dac941a6c06f5236228
13 Ned2199f293b749929d8dfde747c540ff
14 anzsrc-for:11
15 anzsrc-for:1108
16 schema:author N55630949f3d7427699db39efbba8a159
17 schema:citation sg:pub.10.1007/bf01734359
18 sg:pub.10.1007/bf02100115
19 sg:pub.10.1038/333573a0
20 sg:pub.10.1038/336315a0
21 sg:pub.10.1038/374124b0
22 sg:pub.10.1038/374503a0
23 https://app.dimensions.ai/details/publication/pub.1080999772
24 https://app.dimensions.ai/details/publication/pub.1082375719
25 https://app.dimensions.ai/details/publication/pub.1082884631
26 https://app.dimensions.ai/details/publication/pub.1083089730
27 https://doi.org/10.1006/viro.1997.8510
28 https://doi.org/10.1016/0140-6736(90)91561-n
29 https://doi.org/10.1016/0968-0004(88)90129-6
30 https://doi.org/10.1016/s0022-2836(05)80360-2
31 https://doi.org/10.1016/s0140-6736(60)92026-2
32 https://doi.org/10.1016/s0140-6736(83)90644-x
33 https://doi.org/10.1016/s0140-6736(86)91422-4
34 https://doi.org/10.1016/s0140-6736(88)92164-2
35 https://doi.org/10.1016/s0140-6736(96)07063-8
36 https://doi.org/10.1017/s0016672300032481
37 https://doi.org/10.1073/pnas.87.11.4108
38 https://doi.org/10.1073/pnas.93.20.10864
39 https://doi.org/10.1089/aid.1995.11.1413
40 https://doi.org/10.1093/bioinformatics/10.1.41
41 https://doi.org/10.1093/oxfordjournals.molbev.a040503
42 https://doi.org/10.1097/00002030-199001001-00014
43 https://doi.org/10.1097/00002030-199306000-00003
44 https://doi.org/10.1126/science.272.5261.537
45 schema:datePublished 1998-02
46 schema:datePublishedReg 1998-02-01
47 schema:description There is considerable genetic diversity among viruses of different subtypes (designated A to J) in the major group of human immunodeficiency virus type 1 (HIV-1), the form of HIV that is dominant in the global epidemic. If available, HIV-1 sequences pre-dating the recognition of AIDS could be crucial in defining the time of origin and the subsequent evolution of these viruses in humans. The oldest known case of HIV-1 infection was reported to be that of a sailor from Manchester who died of an AIDS-like illness in 1959; however, the authenticity of this case has not been confirmed. Genetic analysis of sequences from clinical materials obtained from 1971 to 1976 from members of a Norwegian family infected earlier than 1971 showed that they carried viruses of the HIV-1 outlier group, a variant form that is mainly restricted to West Africa. Here we report the amplification and characterization of viral sequences from a 1959 African plasma sample that was previously found to be HIV-1 seropositive. Multiple phylogenetic analyses not only authenticate this case as the oldest known HIV-1 infection, but also place its viral sequence near the ancestral node of subtypes B and D in the major group, indicating that these HIV-1 subtypes, and perhaps all major-group viruses, may have evolved from a single introduction into the African population not long before 1959.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N7db320ea31b04511ac38d0eadfc9b9ef
52 Nbacad5a797014ba48636f45564e6e8b6
53 sg:journal.1018957
54 schema:name An African HIV-1 sequence from 1959 and implications for the origin of the epidemic
55 schema:pagination 594-597
56 schema:productId N1593a6d018d640ecb52b229624134c43
57 N5c0194c29e9148b0a1a258c09d8d3e2f
58 N784238412c2d4eb9bd4ede7991f146ec
59 Nb2bc9dd105c541d38d65b19f8eff5764
60 Nfb186ea5ddef4dff8521b75760239815
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023244491
62 https://doi.org/10.1038/35400
63 schema:sdDatePublished 2019-04-11T12:12
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Ndd7877f2e8384e4eb010c68aaddc9f5a
66 schema:url http://www.nature.com/articles/35400
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0617e03e606b417c8b0f77603e00fb1d schema:name ¶PO Box 4087, Worthing BN14 7LQ, UK
71 rdf:type schema:Organization
72 N0922be90a62840dbbb36581d6defc4e3 rdf:first sg:person.01237531654.86
73 rdf:rest N9b9e95a894614d55b95d95820e5cb2e1
74 N1593a6d018d640ecb52b229624134c43 schema:name dimensions_id
75 schema:value pub.1023244491
76 rdf:type schema:PropertyValue
77 N17e035ada07643edaa38fadb60d69909 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Molecular Sequence Data
79 rdf:type schema:DefinedTerm
80 N1878fd8ed1dc4af5a312a0acf0cef6d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Humans
82 rdf:type schema:DefinedTerm
83 N27b046702702437ca6e717d9a2872ae7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name RNA, Viral
85 rdf:type schema:DefinedTerm
86 N3eaa8e321c7141fc80d13a9036f5b37e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Evolution, Molecular
88 rdf:type schema:DefinedTerm
89 N43b6939c02f149b791a71de474dde7c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Sequence Alignment
91 rdf:type schema:DefinedTerm
92 N5129754893c44b0c866d0f2e5a49ba72 rdf:first sg:person.01342202624.34
93 rdf:rest rdf:nil
94 N55630949f3d7427699db39efbba8a159 rdf:first sg:person.0630363256.06
95 rdf:rest N0922be90a62840dbbb36581d6defc4e3
96 N5c0194c29e9148b0a1a258c09d8d3e2f schema:name nlm_unique_id
97 schema:value 0410462
98 rdf:type schema:PropertyValue
99 N621b91f57e5343aba258f5ce42014f97 rdf:first N68f36edff9c84cc69503a01a0e48050e
100 rdf:rest Nbd53daafdc984245a383d6bc2584eabb
101 N68f36edff9c84cc69503a01a0e48050e schema:affiliation N0617e03e606b417c8b0f77603e00fb1d
102 schema:familyName Hooper
103 schema:givenName Edward
104 rdf:type schema:Person
105 N7675c2bf8d0f43dcb8e350439f530977 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name History, 20th Century
107 rdf:type schema:DefinedTerm
108 N784238412c2d4eb9bd4ede7991f146ec schema:name readcube_id
109 schema:value 6ebdea3577596412bfdec91b248237c0f373d3ca195c049d47a341eacd552635
110 rdf:type schema:PropertyValue
111 N7db320ea31b04511ac38d0eadfc9b9ef schema:volumeNumber 391
112 rdf:type schema:PublicationVolume
113 N85481099b4b647668826e82e53451a2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Polymerase Chain Reaction
115 rdf:type schema:DefinedTerm
116 N867b34e9050e4071a718d8357459b360 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Phylogeny
118 rdf:type schema:DefinedTerm
119 N953d30f12db34f698f3b8db4d2a64ac6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Democratic Republic of the Congo
121 rdf:type schema:DefinedTerm
122 N9b20cc44178944a3b03041c1618ddd9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name HIV-1
124 rdf:type schema:DefinedTerm
125 N9b9e95a894614d55b95d95820e5cb2e1 rdf:first sg:person.0100237752.52
126 rdf:rest N621b91f57e5343aba258f5ce42014f97
127 Nb2bc9dd105c541d38d65b19f8eff5764 schema:name pubmed_id
128 schema:value 9468138
129 rdf:type schema:PropertyValue
130 Nb988e50e3f1c4ad1b4e4508e5051e9b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Male
132 rdf:type schema:DefinedTerm
133 Nbacad5a797014ba48636f45564e6e8b6 schema:issueNumber 6667
134 rdf:type schema:PublicationIssue
135 Nbd53daafdc984245a383d6bc2584eabb rdf:first sg:person.011734705062.72
136 rdf:rest N5129754893c44b0c866d0f2e5a49ba72
137 Nd1c7d8913ed04dac941a6c06f5236228 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Disease Outbreaks
139 rdf:type schema:DefinedTerm
140 Ndd7877f2e8384e4eb010c68aaddc9f5a schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Ne5c073f83d6f40d99aee702b0538ec1d schema:name #Department of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
143 rdf:type schema:Organization
144 Ned2199f293b749929d8dfde747c540ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name HIV Infections
146 rdf:type schema:DefinedTerm
147 Nfb186ea5ddef4dff8521b75760239815 schema:name doi
148 schema:value 10.1038/35400
149 rdf:type schema:PropertyValue
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical Microbiology
155 rdf:type schema:DefinedTerm
156 sg:journal.1018957 schema:issn 0090-0028
157 1476-4687
158 schema:name Nature
159 rdf:type schema:Periodical
160 sg:person.0100237752.52 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
161 schema:familyName Nahmias
162 schema:givenName Andre J.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0100237752.52
164 rdf:type schema:Person
165 sg:person.011734705062.72 schema:affiliation Ne5c073f83d6f40d99aee702b0538ec1d
166 schema:familyName Sharp
167 schema:givenName Paul M.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011734705062.72
169 rdf:type schema:Person
170 sg:person.01237531654.86 schema:affiliation https://www.grid.ac/institutes/grid.209665.e
171 schema:familyName Korber
172 schema:givenName Bette T.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237531654.86
174 rdf:type schema:Person
175 sg:person.01342202624.34 schema:affiliation https://www.grid.ac/institutes/grid.134907.8
176 schema:familyName Ho
177 schema:givenName David D.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342202624.34
179 rdf:type schema:Person
180 sg:person.0630363256.06 schema:affiliation https://www.grid.ac/institutes/grid.134907.8
181 schema:familyName Zhu
182 schema:givenName Tuofu
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630363256.06
184 rdf:type schema:Person
185 sg:pub.10.1007/bf01734359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044065382
186 https://doi.org/10.1007/bf01734359
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/bf02100115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026773907
189 https://doi.org/10.1007/bf02100115
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/333573a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006062861
192 https://doi.org/10.1038/333573a0
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/336315a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050092899
195 https://doi.org/10.1038/336315a0
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/374124b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052214377
198 https://doi.org/10.1038/374124b0
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/374503a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026329685
201 https://doi.org/10.1038/374503a0
202 rdf:type schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1080999772 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1082375719 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1082884631 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1083089730 schema:CreativeWork
207 https://doi.org/10.1006/viro.1997.8510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048761115
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0140-6736(90)91561-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1049421013
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0968-0004(88)90129-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042259073
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0022-2836(05)80360-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013618994
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0140-6736(60)92026-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034809857
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0140-6736(83)90644-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028750122
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0140-6736(86)91422-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007148169
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0140-6736(88)92164-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010732129
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0140-6736(96)07063-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013566630
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1017/s0016672300032481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054035055
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1073/pnas.87.11.4108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000773771
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1073/pnas.93.20.10864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046563271
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1089/aid.1995.11.1413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059224054
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/bioinformatics/10.1.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059413334
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1093/oxfordjournals.molbev.a040503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079727097
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/00002030-199001001-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006959374
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1097/00002030-199306000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014586986
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1126/science.272.5261.537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552853
242 rdf:type schema:CreativeWork
243 https://www.grid.ac/institutes/grid.134907.8 schema:alternateName Rockefeller University
244 schema:name *Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
247 schema:name ‖Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30303, USA
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.209665.e schema:alternateName Santa Fe Institute
250 schema:name §The Santa Fe Institute, Santa Fe, New Mexico 87501, USA
251 ‡Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
252 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...