Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-09

AUTHORS

B P Brunk, E C Martin, P N Adler

ABSTRACT

The Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and bithorax (bx-C) complexes, and hence for the maintenance of segmental determination. We report the predicted protein sequence of the Pc-G gene Posterior Sex Combs (Psc), and of the neighbouring and related gene Suppressor two of zeste (Su(z)2). Both genes encode large proteins that contain a 200 amino-acid domain identical over 37.4% that is also conserved in the murine oncogene bmi-1. At the amino terminus of this domain is a cysteine-rich sequence that has been proposed as a novel type of zinc finger. More... »

PAGES

351-353

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/353351a0

DOI

http://dx.doi.org/10.1038/353351a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014491176

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1833647


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