The B-cell antigen receptor of the five immunoglobulin classes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-08

AUTHORS

Ashok R. Venkitaraman, Gareth T. Williams, Piona Dariavach, Michael S. Neuberger

ABSTRACT

Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the α and β associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, α common a chain associ-ates with all five immunoglobulin classes. We pro-pose that B-cell antigen receptors consist of a common α/β heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated α chain and in their dependence on α/β for surface transport. More... »

PAGES

777-781

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/352777a0

DOI

http://dx.doi.org/10.1038/352777a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006731367

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1881434


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