Making antibody fragments using phage display libraries View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-08

AUTHORS

Tim Clackson, Hennie R. Hoogenboom, Andrew D. Griffiths, Greg Winter

ABSTRACT

To by-pass hybridoma technology and animal immunization, we are trying to build antibodies in bacteria by mimicking features of immune selection1. Recently we used fd phage2 to display antibody fragments fused to a minor coat protein3,4, allowing enrichment of phage with antigen3. Using a random combinatorial library of the rearranged heavy (VH) and kappa (Vk) light chains5– from mice immune to the hapten 2-phenyloxazol-5-one (phOx), we have now displayed diverse libraries of antibody fragments on the surface of fd phage. After a single pass over a hapten affinity column, fd phage with a range of phOx binding activities were detected, at least one with high affinity (dissociation constant, Kd = 10-8 M). A second pass enriched for the strong binders at the expense of the weak. The binders were encoded by V genes similar to those found in anti-phOx hybridomas but in promiscuous combinations (where the same V gene is found with several different partners). By combining a promiscuous VH or VK gene with diverse repertoires of partners to create hierarchical libraries, we elicited many more pairings with strong binding activities. Phage display offers new ways of making antibodies from V-gene libraries, altering V-domain pairings and selecting for antibodies with good affinities. More... »

PAGES

624-628

Journal

TITLE

Nature

ISSUE

6336

VOLUME

352

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  • Nucleic Acids Encoding Anti-Neonatal Fc Receptor (Fcrn) Antibodies
  • Anti-Gpr49 Monoclonal Antibodies
  • Host Cell Specific Binding Molecules Capable Of Neutralizing Viruses And Uses Thereof
  • Methods Of Modifying Antibodies For Purification Of Bispecific Antibodies
  • Methods And Reagents For Diagnosing Rheumatoid Arthrtis
  • Synthesis And Intermediates Of Pyrrolobenzodiazepine Derivatives For Conjugation
  • Binding Proteins, Ligation Polynucleotides And Insertion Gene Coding
  • T Cell Receptors And Engineered Cells Expressing Same
  • Anti-Transferrin Receptor Antibodies And Uses Thereof
  • Cells Expressing Chimeric Activating Receptors And Chimeric Stimulating Receptors And Uses Thereof
  • Mutant Proteins And Methods For Producing Them
  • Process For Producing Antibodies
  • Pharmaceutical Compositions Of Il-22 Fc Fusion Proteins
  • Bispecific Egfr/Igfir Binding Molecules
  • Molecularly Engineered Binding Domain-Immunoglobulin Fusion Proteins, Including Single Chain Fv-Immunoglobulin Fusion Protein Useful For Treating Malignant Conditions And B-Cell Disorders, Such As Disease Caused By Autoantibody Production; Chronic Lymphocytic Leukemia
  • Methods Of Treating A Crystal Induced Arthropathy Using Il-1beta Antibodies
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Optimized Variants Of Anti-Vegf Antibodies And Methods Of Use Thereof In Treatment
  • Cell Culture Compositions With Antioxidants And Methods For Polypeptide Production
  • Use Of Listeria Vaccine Vectors To Reverse Vaccine Unresponsiveness In Parasitically Infected Individuals
  • Serum Albumin Binding Molecules
  • Anti-Vegf Antibodies
  • Cation Exchange Chromatography Methods
  • Human Serum Albumin Linkers And Conjugates Thereof
  • Stem Cell Factor Inhibitor
  • Antibodies Recognizing A Carbohydrate Containing Epitope On Cd-43 And Cea Expressed On Cancer Cells And Methods Using Same
  • Prognosis Of Nephritis By Determination Of Presence Of Immunoglobulin G Antibodies Cross-Reactive With Antibodies To Double Stranded Dna And Denatured Anti-A And D Snrnp Proteins In A Lupus Patient
  • Methods For Treating Pain By Administering A Nerve Growth Factor Antagonist And An Nsaid And Compositions Containing The Same
  • Use Of Caprylic Acid Precipitation For Protein Purification
  • Kinase Specific Immunoglobulins For Prevention And Treatment Of Cell Proliferative Disorders
  • Covalently Linked Helicar-Anti-Helicar Antibody Conjugates And Uses Thereof
  • Method Of Inhibiting Acute Complement Mediated Cytotoxicity With Anti-Idiotypic Antibodies
  • Genetic Engineered Antibody Or Antigen Binding Segment That Is Capable Of Binding To Interleukins And Altering The Conformation Structure, Used For Treating Diseases Involving Immune And Inflammatory Responses
  • Use Of Anti-Endoglin Antibodies For Treating Ocular Fibrosis
  • Antibody Drug Conjugates (Adcs) With Kinesin Spindel Protein (Ksp)
  • Reaction-Based Selection For Expression Of And Concentration Of Catalytic Moieties
  • Method Of Screening For Anti-Garp Antibodies
  • High-Affinity Anti-Mertk Antibodies And Uses Thereof
  • Serum Albumin Binding Molecules
  • Antibodies Specific For Native Prpsc
  • Polymerase Enzyme Substrates With Protein Shield
  • Antibodies To Tgf-Β
  • Antibodies That Bind Il-4 And/Or Il-13 And Their Uses
  • Methods For Identifying Factors For Differentiating Definitive Endoderm
  • Compositions And Methods Of Use For Antibodies Of Dickkopf-1
  • Nucleic Acid-Polypeptide Compositions And Methods Of Inducing Exon Skipping
  • Multivalent And Multiepitopic Antibodies Having Agonistic Activity And Methods Of Use
  • Antibody Constructs For Dll3 And Cd3
  • Nucleic Acids Encoding Anti-Siglec-15 Antibodies
  • High Affinity Antibodies Against Hmgb1 And Methods Of Use Thereof
  • Structural Isomers Of Sc(Fv)2
  • Antibodies Specific For Cd3 And Uses Thereof
  • Constant Chain Modified Bispecific, Penta- And Hexavalent Ig-M Antibodies
  • Anti-B7-H4 Antibodies And Immunoconjugates
  • Treatment Of Septicemia
  • Methods For Producing Polypeptides By Regulating Polypeptide Association
  • Antibodies To C-Met
  • Method Of Treating Type 1 Diabetes By Administering Nkp46 Polypeptide
  • Optimized Variants Of Anti-Vegf Antibodies And Methods Of Treatment Thereof By Reducing Or Inhibiting Angiogenesis
  • Nucleic Acid-Polypeptide Compositions And Methods Of Inducing Exon Skipping
  • Assay For Cardiac Troponin-T (Ctnt)
  • Antibody Formulations
  • Diagnostic And Prognostic Methods For Cardiovascular Diseases And Events
  • Internalizing Erbb2 Antibodies
  • Specific Binding Molecules For Scintigraphy, Conjugates Containing Them And Therapeutic Method For Treatment Of Angiogenesis
  • Compositions And Methods For The Therapy And Diagnosis Of Cytomegalovirus Infections
  • Humanized Antibodies To Cluster Of Differentiation 3 (Cd3)
  • Enhancement Of Antibody-Mediated Immune Responses
  • High Affinity Antibodies Against Hmgb1 And Methods Of Use Thereof
  • Depth Filters For Disposable Biotechnological Processes
  • Anti-Ngf Antibodies And Methods Using Same
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Stable Igg4 Based Binding Agent Formulations
  • Compounds For Inducing Anti-Tumor Immunity And Methods Thereof
  • Trem2 Cleavage Modulators And Uses Thereof
  • Nucleic Acid Molecules Encoding For Bace1 Antibodies
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Histone Deacetylases, And Uses Related Thereto
  • Antibodies Of The Ed-B Domain Of Fibronectin, Their Construction And Uses
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Anti-O1 Antibodies And Uses Thereof
  • Extracellular Matrix Metalloproteinase Inducer (Emmprin) Peptides And Binding Antibodies
  • Anti-Cd26 Antibodies And Methods Of Use Thereof
  • Selecting And Isolating A Subpopulation Of Viruses Or Organisms Which Express Suface-Bound Catalytic Moiety Such As A Catalytic Antibody Based On A Reaction
  • Formulations Useful In The Treatment Of Proliferative Diseases Affecting The Respiratory Tract
  • Wise Binding Agents And Epitopes
  • Humanized Anti-Tau(Ps422) Antibody Brain Shuttles And Use Thereof
  • Compositions And Methods Of Treating Muscle Atrophy And Myotonic Dystrophy
  • Antibodies Against Platelet-Derived Growth Factor (Pdgf)
  • Methods For Treating, Diagnosing, And Monitoring Lupus
  • Anti-Ige Antibodies And Methods Of Improving Polypeptides
  • Wnt Signalling In Reproductive Organs
  • Viscosity Reduction Of Highly Concentrated Protein Formulations
  • Tumor Specific Antibody
  • Rtk-Bpb Specifically Binding To Rtk
  • Methods For Increasing Definitive Endoderm Production
  • Viscosity Reduction Of Highly Concentrated Protein Formulations
  • Tumor Specific Antibody
  • Rtk-Bpb Specifically Binding To Rtk
  • Wnt Signalling In Reproductive Organs
  • Anti-Mpl Antibodies
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Glycan Arrays On Ptfe-Like Aluminum Coated Glass Slides And Related Methods
  • Microarrays And Uses Therefor
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Antibodies To Lymphotoxin-Alpha
  • Neuropilin Antagonists
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Diagnosis And Treatments Relating To Th2 Inhibition
  • Apparatus For Continuous Directed Evolution Of Proteins And Nucleic Acids
  • Il-22 Fc Fusion Proteins
  • Method To Detect Autoantibody Reactivity For Deamidated Insulin Autoantigen In Diabetes
  • Human Binding Molecules Having Killing Activity Against Staphylococci And Uses Thereof
  • Treating Inflammatory Disease, Autoimmune Disease With A Polypeptide Which Does Not Contain A Vertebrate High Mobility Group Box Protein (Hmgb); Inhibit The Release Of A Proinflammatory Cytokine With Antagonist Of Tnf
  • Engineered Multivalent And Multispecific Binding Proteins; Treatment Of Acute And Chronic Inflammatory, Cancer
  • Used For The For The Medical Diagnosis And Treatment Of Alzheimer's Disease
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Methods For Inducing Or Enhancing An Immune Response By Administering Agonistic Glucocorticoid-Induced Tnfr-Family-Related Receptor (Gitr) Antibodies
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Treatment Of Tumors Using Specific Anti-L1 Antibody
  • Biomarker For Replicative Senescence
  • Methods For Assessing Responsiveness Of B-Cell Lymphoma To Treatment With Anti-Cd40 Antibodies
  • Protein Recovery
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Shuffling Polynucleotides By Incomplete Extension
  • Methods Of Treatment Using Human Antibodies That Bind Il-12
  • Pyrrolobenzodiazepine Conjugates
  • Antibodies To The Human Prolactin Receptor
  • Icam-1 Binding Antibodies
  • Distinction Of Infectious Virus Based On Molecular Biomarker And Neutralization Of Virus Causing Food Poisoning
  • Protease Screening Methods And Proteases Identified Thereby
  • Antibodies To Tgf-Beta
  • Or Antibody Fragment Which Is Specific For And Binds Directly To The Ed B Oncofetal Domain Of Fibronectin; Diagnostic Kits For Cancer Treatment
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Methods For Identifying Inducers And Inhibitors Of Proteolytic Antibodies, Compositions And Their Uses
  • Monoclonal Antibody Or An Fab Fragment Capable Of Binding To Mouse Vascular Endothelial Cell Growth Factor (Vegf) And Human Vegf; Cancer, Diabetes Related Diseases, Age-Induced Macular Degeneration
  • Therapeutic Compositions Comprising Anti-Ige Antibodies And Immunosuppressive Agent
  • Isolated Nucleic Acids Encoding Anti-Sortilin Antibodies
  • Tgfβr1 Inhibitor Combination Therapies
  • Anti-Aβ Globulomer 7c6 Antibodies
  • Ionic Strength-Mediated Ph Gradient Ion Exchange Chromatography
  • Method For The Treatment Of Inflammatory Disorders
  • Compositions For Inhibiting Masp-2 Dependent Complement Activation
  • Methods For Producing Antibody Libraries Using Universal Or Randomized Immunoglobulin Light Chains
  • Polynucleotides Encoding Humanized Antibodies Against Ceacam1
  • Methods And Compositions For Ameliorating Pancreatic Cancer
  • Polypeptide Having An Antibody Antigen Binding Domain With High Affinity For Estradiol And Low Cross-Reactivity To Other Common Steroid Hormones; For Immunoassay Monitoring And Diagnosing Of In Vivo Hormone Levels And Related Diseases
  • Bipodal-Peptide Binder
  • Diagnostic, Prognostic, And Monitoring Methods For Multiple Myeloma, Chronic Lymphocytic Leukemia, And B-Cell Non-Hodgkin Lymphoma
  • Binding Polypeptides With Diversified And Consensus Vh/Vl Hypervariable Sequences
  • Immunoassay Using At Least Two Pegylated Analyte-Specific Binding Agents
  • Crystalline Anti-Human Il-12 Antibodies
  • Klebsiella Antigens
  • Treatment Methods Using C-Met Antibodies
  • Charged Linkers And Their Uses For Conjugation
  • Anti-B7-H4 Antibodies And Immunoconjugates
  • Immunoconjugates Targeting Cd46 And Methods Of Use Thereof
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Anti-Pd-L1 Antibodies And Uses Therefor
  • Binding Proteins, Ligation Polynucleotides And Insertion Gene Coding
  • Bispecific Antibodies Directed Against Human 90k And Either Endosialin Or Her3
  • Including Fibronectin Type Iii Domain With Randomized Loop; For Diagnosis/Genetic Engineering/Drug Screening Immunomodulators
  • Ati-Tat88 Polypeptide Antibody; Anticarcinogenic Agent; Expression Vector Containign A Nucleic Acid Operably Linked To Control Sequences Recognized By A Host Cell Transformed With The Vector
  • Humanized Anti-Human Cd19 Antibodies And Methods Of Use
  • Antibodies To Vla-1
  • Antibodies To M-Csf
  • Hcv Ns3 Recombinant Antigens And Mutants Thereof For Improved Antibody Detection
  • Indications For Anti-Il-1 Beta Therapy
  • Library Of Antigen-Binding Molecules Including Modified Antibody Variable Region
  • Selection System
  • Compounds And Conjugates Thereof
  • Isolation And Production Of Catalytic Antibodies Using Phage Technology
  • Hcv Core Lipid Binding Domain Monoclonal Antibodies
  • Antibodies, Binding Fragments, And Methods Of Use
  • Manufacturing Method
  • Antibodies To Lymphotoxin-Alpha
  • Providing Related-Sequence Double-Stranded Template Polynucleotide And Single-Stranded Nucleic Acid Fragments Capable Of Hybridizing To The Template Polynucleotides; Hybridizing; Recombination
  • Cell Culture Compositions With Antioxidants And Methods For Polypeptide Production
  • Immunoassay System Simplifies Diagnosis Of Rickettsia; Sequenced And Cloned Gene Expressing The Major Surface Protein 5 Used As Immunogenic And Diagnostic Test Antigen; Genetic Engineering And Expression
  • Quick, Efficient Method By Expressing From Bacterial Cell Nucleic Acids That Encode Bacterial Signal Sequences Linked To Heavy Chain And Light Chain, Chains Are Transported Through Cytoplasmic Membrane Into Periplasmic Space Or Medium
  • Automated Sorting System For Matrices With Memory
  • Reactive Labelling Compounds And Uses Thereof
  • Optimized Variants Of Anti-Vegf Antibodies And Methods Of Use Thereof In Treatment
  • Cell Culture Compositions With Antioxidants And Methods For Polypeptide Production
  • Use Of Listeria Vaccine Vectors To Reverse Vaccine Unresponsiveness In Parasitically Infected Individuals
  • Methods Of Treating A Crystal Induced Arthropathy Using Il-1beta Antibodies
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Human M2e Peptide Immunogens
  • Mutant Proteins And Methods For Producing Them
  • Process For Producing Antibodies
  • Pharmaceutical Compositions Of Il-22 Fc Fusion Proteins
  • Bispecific Egfr/Igfir Binding Molecules
  • Molecularly Engineered Binding Domain-Immunoglobulin Fusion Proteins, Including Single Chain Fv-Immunoglobulin Fusion Protein Useful For Treating Malignant Conditions And B-Cell Disorders, Such As Disease Caused By Autoantibody Production; Chronic Lymphocytic Leukemia
  • Methods Of Modifying Antibodies For Purification Of Bispecific Antibodies
  • Methods And Reagents For Diagnosing Rheumatoid Arthrtis
  • Methods And Compositions For The Treatment Of Cancer
  • Multispecific Antibodies
  • Methods For Detecting Protein Binding Sequences And Tagging Nucleic Acids
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Targeting Capn9/Capns2 Activity As A Therapeutic Strategy For The Treatment Of Myofibroblast Differentiation And Associated Pathologies
  • Diagnosis And Treatments Relating To Th2 Inhibition
  • Tgfβr1 Inhibitor Combination Therapies
  • Anti-Aβ Globulomer 7c6 Antibodies
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Anti-Htra1 Antibodies And Methods Of Use
  • Method For The Treatment Of Amyloidoses
  • Treatment Of Tumors Using Specific Anti-L1 Antibody
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Engineered Multivalent And Multispecific Binding Proteins; Treatment Of Acute And Chronic Inflammatory, Cancer
  • Methods For Assessing Responsiveness Of B-Cell Lymphoma To Treatment With Anti-Cd40 Antibodies
  • Apparatus For Continuous Directed Evolution Of Proteins And Nucleic Acids
  • Il-22 Fc Fusion Proteins
  • Human Binding Molecules Having Killing Activity Against Staphylococci And Uses Thereof
  • Treating Inflammatory Disease, Autoimmune Disease With A Polypeptide Which Does Not Contain A Vertebrate High Mobility Group Box Protein (Hmgb); Inhibit The Release Of A Proinflammatory Cytokine With Antagonist Of Tnf
  • Biological Materials And Uses Thereof
  • Methods For Treating Bone Cancer Pain By Administering A Nerve Growth Factor Antagonist Antibody
  • Performing Polymerse Chain Reaction Amplification To Generate A Population Of Partially Annealed Recombined Polynucleotides In Concatemeric Form; Introduce Concatemers Into Cells And Screen For Desired Functional Properties
  • Method For Treating Breast Cancer
  • Transgenic Animals Expressing Chimeric Antibodies For Use In Preparing Human Antibodies
  • Biological Materials And Uses Thereof
  • Modulators
  • Monoclonal Antibodies, Compositions And Methods For Detecting Mucin-Like Protein (Mlp) As A Biomarker For Ovarian And Pancreatic Cancer
  • Antibody-Active Agent Conjugates And Methods Of Use
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Providing A Library Of Peptides Comprising A Trpzip Scaffold, Contacting The Library With The Bioactive Target Molecule; Selecting At Least One Peptide Capable Of Forming A Noncovalent Complex With The Bioactive Target Molecule From The Library; Isolating Peptide
  • Siglec-15 Antibodies In Treating Bone Loss-Related Disease
  • Transgenic Non-Human Animals For Producing Chimeric Antibodies
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Fast-Off Rate Serum Albumin Binding Fibronectin Type Iii Domains
  • High Affinity Human Antibodies To Tumor Antigens
  • Methods Of Eliciting Broadly Neutralizing Antibodies Targeting Hiv-1 Gp41
  • Anti-B7-H4 Antibodies And Immunoconjugates
  • Anti-Epidermal Growth Factor Receptor (Egfr) Antibodies
  • Human Complementarity Determining Region (Cdr)-Grafted Antibody To Ganglioside Gm2
  • Method For The Treatment Of Inflammatory Disorders
  • Methods And Compositions For Treatment Of Cancer
  • Methods Of Treating Acute Pancreatitis Using Il-22 Fc Fusion Proteins
  • Bispecific Anti-Hapten/Anti-Blood Brain Barrier Receptor Antibodies, Complexes Thereof And Their Use As Blood Brain Barrier Shuttles
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Anti-Dll4/Vegf Dual Variable Domain Immunoglobulin And Uses Thereof
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Bcma And Cd3 Bispecific T Cell Engaging Antibody Constructs
  • Antibodies Specific For Immunoglobulin-Like Transcript 3 (Ilt3) And Uses Thereof
  • Methods For Treating Chronic Sinusitis With Nasal Polyps By Administering An Il-4r Antagonist
  • Therapeutic Peptides
  • Compositions And Method For Treating Complement-Associated Conditions
  • Antibody Drug Conjugates (Adc) That Bind To Cd37 Proteins
  • Antibodies And Chimeric Antigen Receptors Specific For Cd19
  • Polynucleotides Encoding Bispecific Egfr/Igf-Ir Binding Molecules
  • Multimers, Tetramers And Octamers
  • Rationally Designed, Synthetic Antibody Libraries And Uses Therefor
  • Polymerases, Compositions, And Methods Of Use
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Preprimitive Streak And Mesendoderm Cells
  • Antibodies Specifically Binding To Masp-3 For The Treatment Of Various Diseases And Disorders
  • Methods And Compositions For Cellular And Metabolic Engineering
  • Comprises A Filamentous Bacteriophage Particle Displaying On Its Surface A Binding Molecule Which Has A Binding Domain Able To Bind Target Epitope Or Antigen; Genetic Engineering
  • Anti-Axl Antibodies And Methods Of Use
  • Il-17 Binding Proteins
  • Multi-Specific Fab Fusion Proteins Comprising A Cd3-Binding Fab Fragment With N-Terminal Fusion To Binding Domains And Methods Of Use
  • Treatment For Inflammatory Bowel Disease With A Fibronectin Polypeptide
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Treatment With Anti-Alpha2 Integrin Antibodies
  • Definitive Endoderm
  • Antibodies To Human Programmed Death Receptor Pd-1
  • Identification Of Antigen- Or Ligand-Specific Binding Proteins
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Anti-Pmel17 Antibodies And Immunoconjugates
  • Nucleic Acids Encoding Il-22 Fc Fusion Proteins
  • Method Of Treating Cancer By Administering Egfr And Egfr/Igfir Binding Molecules
  • High Throughput Generation And Affinity Maturation Of Humanized Antibody
  • Methods Of Inducing Or Enhancing An Immune Response In A Subject Having Cancer By Administering Gitr Antibodies
  • Capable Of Binding To Mouse Vascular Endothelial Cell Growth Factor (Vegf) And Human Vegf; Cancer, Diabetes Related Diseases, Edema, Inflammation
  • In Vitro Methods Of Producing And Identifying Immunoglobulin Molecules In Eukaryotic Cells
  • Method Of Treating Cancer By Administering An Anti-Lgr5 Monoclonal Antibody
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Human Antibodies That Bind Human Il-12
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Methods And Compositions For Assessing Responsiveness Of B-Cell Lymphoma To Treatment With Anti-Cd40 Antibodies
  • Hcv Antigen-Antibody Combination Assay And Methods And Compositions For Use Therein
  • Hmg1 Antibody For Treating Inflammatory Conditions
  • Methods For Inducing Or Enhancing An Immune Response By Administering Agonistic Gitr-Binding Antibodies
  • Eribulin-Based Antibody-Drug Conjugates And Methods Of Use
  • Methods Of Treating Inflammatory Bowel Disease Using Il-22 Fc Fusion Proteins
  • Alpha-Synuclein Antibodies
  • Anti-Aβ Globulomer 5f7 Antibodies
  • Recombinant Antibodies Against Hepatitis C Virus And Methods Of Obtaining And Using Same
  • Use Of Low Temperature And/Or Low Ph In Cell Culture
  • For Indentifying Receptor-Independent Activators Of Pheromone Response Pathway; Devised In Yeast Saccharomyces Cerevisiae; Activator Of G-Protein Signaling (Ags)
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Host Cell Specific Binding Molecules Capable Of Neutralizing Viruses And Uses Thereof
  • Assays For Detecting T Cell Immune Subsets And Methods Of Use Thereof
  • Antigen-Binding Proteins Targeting S. Aureus Orf0657n
  • Antibodies Against Kidney Associated Antigen 1 And Antigen Binding Fragments Thereof
  • Gene Expression Markers And Treatment Of Multiple Sclerosis
  • Anti-Ige Antibodies And Method Of Improving Polypeptides
  • Proteomic Identification Of Antibodies
  • Anti-Baff Antibodies
  • Prostate Cancer-Related Compositions, Methods, And Kits Based On Dna Macroarray Proteomics Platforms
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Anti-Cd33 Antibodies And Methods Of Use Thereof
  • Therapeutic Dll4 Binding Proteins
  • Compositions For Inhibiting Masp-2 Dependent Complement Activation
  • Decreasing Lactate Level And Increasing Polypeptide Production By Downregulating The Expression Of Lactate Dehydrogenase And Pyruvate Dehydrogenase Kinase
  • Coiled Coil And/Or Tether Containing Protein Complexes And Uses Thereof
  • Anti-Transferrin Receptor Antibodies And Uses Thereof
  • Methods For Producing Members Of Specific Binding Pairs
  • Fusion Proteins For Modulating Regulatory And Effector T Cells
  • Biosynthetic Binding Proteins For Immunotargeting
  • Anti-Activin A Antibodies And Uses Thereof
  • Methods Of Accelerating Or Improving Wound Healing Using Il-22 Fc Fusion Proteins
  • Fibronectin Based Scaffold Proteins Having Improved Stability
  • Antibody Producing Non-Human Animals
  • Synthesis Of Hybrid Polynucleotide Molecules Using Single-Stranded Polynucleotide Molecules
  • Modulators
  • Methods For Treating Psoriasis By Administering An Antibody Which Binds An Epitope Of The P40 Subunit Of Il-12 And/Or Il-23
  • Methods Of Impairing Osteoclast Differentiation Using Antibodies That Bind Siglec-15
  • Serum Albumin-Binding Fibronectin Type Iii Domains
  • Composition And Method For The Diagnosis And Treatment Of Iron-Related Disorders
  • Fc Receptor Antibodies And Methods Of Use Thereof
  • Pax 5 Monoclonal Antibody
  • Antibodies To Vla-1
  • Antibody Formulations
  • In Vitro Methods Of Producing And Identifying Immunoglobulin Molecules In Eukaryotic Cells
  • Method Of Treating Cancer By Administering An Anti-Lgr5 Monoclonal Antibody
  • Amyloid Β(1-42) Oligomers, Derivatives Thereof And Antibodies Thereto, Methods Of Preparation Thereof And Use Thereof
  • Signal Biomarkers
  • Psma And Cd3 Bispecific T Cell Engaging Antibody Constructs
  • Anti-Siglec-7 Antibodies And Methods Of Use Thereof
  • Human Antibodies That Bind Human Interleukin-12
  • Humanized Anti-Tau(Ps422) Antibodies And Methods Of Use
  • Humanized Anti-Amyloid Antibody
  • Antibodies To Human Programmed Death Receptor Pd-1
  • Anti-Cd33 Antibodies And Methods Of Use Thereof
  • Immunoassay Methods And Reagents For Decreasing Nonspecific Binding
  • Anti-Human Xcr1 Antibodies
  • Methods For Screening For Binding Partners Of G-Protein Coupled Receptors
  • Polynucleotides Encoding Notch Receptor Antibodies
  • Method And Apparatus To Identify Vulnerable Plaques With Thermal Wave Imaging Of Heated Nanoparticles
  • Vaccine Compositions And Methods For Restoring Nkg2d Pathway Function Against Cancers
  • Anti-Transferrin Receptor / Anti-Bace1 Multispecific Antibodies And Methods Of Use
  • Protease Screening Methods And Proteases Identified Thereby
  • Composition And Method For Diversification Of Target Sequences
  • Glycan Conjugates And Methods Of Use Thereof
  • Use Of Listeria Vaccine Vectors To Reverse Vaccine Unresponsiveness In Parasitically Infected Individuals
  • Methods Of Improving Vaccine Immunogenicity
  • Recombination Of Polynucleotide Sequences Using Random Or Defined Primers
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Assay For Diagnosis Of Cardiac Myocyte Damage
  • Antibodies To Receptor Of Advanced Glycation End Products (Rage) And Uses Thereof
  • Immunoglobulin For Use In The Treatment Of Arthritis, Crohn's, Autoimmune, Inflammatory, Nervous System Skin And Diabetic Disorders
  • For Expression In Host Cell; Includes Gene Coding For Repressor And An Associated Promoter, An Insertion Site For Insertional Deactivation Of Repressor, A Surface-Expressed Gene Encoding For Type I Fimbriae, And Operator; Automatic
  • Notch1 Receptor Antibodies And Methods Of Treatment
  • High Affinity Tcr Proteins And Methods
  • Method Of Enhancing Proliferation Or Differentiation Of Hematopoietic Stem Cells Using Wnt Polypeptides
  • Antibodies Specific To Human Poliovirus Receptor (Pvr)
  • Preparation Of Scfv Antibody Fragments
  • Antibodies To Madcam
  • High Throughput Sequencing Of Multiple Transcripts
  • Antibody Drug Conjugates Of Kinesin Spindel Protein (Ksp) Inhibitors With Antib7h3-Antibodies
  • Yeast Cell Surface Display Of Proteins And Uses Thereof
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Bcma And Cd3 Bispecific T Cell Engaging Antibody Constructs
  • Saccharide-Based Biomarkers And Therapeutics
  • Method For Treating Glioblastoma Or Glioma With Antibody Constructs For Egfrviii And Cd3
  • Isolation And Purification Of Anti-Il-13 Antibodies Using Protein A Affinity Chromatography
  • Anti-Ngf Antibodies And Methods Using Same
  • Multispecific Fab Fusion Proteins And Use Thereof
  • Il-17 Binding Proteins
  • Bioassay; Drug Screening A Recombined Polynucleotides, Using Overlapping Nucleic Acids, Priming Polynucleotide Elongation Upon Hybridization To The Target Nucleic Acid; Mutagenesis, For Producing Mutant Enzyme, Antibodies, Therapeutic Proteins
  • Ultrapurified Dsba And Dsbc And Methods Of Making And Using The Same
  • Composition For Diagnosis Of Liver Metastasis Of Colorectal Cancer And The Use Thereof
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Bcma And Cd3 Bispecific T Cell Engaging Antibody Constructs
  • Antibodies Specific For Immunoglobulin-Like Transcript 3 (Ilt3) And Uses Thereof
  • Methods For Treating Chronic Sinusitis With Nasal Polyps By Administering An Il-4r Antagonist
  • Dioxanes And Uses Thereof
  • Compositions And Methods For Treatment And Detection Of Cancers
  • Anti-Cxcr4 Antibodies And Antibody-Drug Conjugates
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Methods For Inhibiting Angiogenesis In A Subject In Need Thereof
  • Bifunctional Histone Deacetylase Inhibitors
  • Antibody Constructs For Cd70 And Cd3
  • Preparing Preferential Nucleotide Sequences Via Dna Repair And Heteroduplex Conversion; Directed Protein Evolution
  • Activin Type 2 Receptor Antibodies
  • Therapeutic Peptides
  • Compositions And Method For Treating Complement-Associated Conditions
  • Modified Polymerases For Improved Incorporation Of Nucleotide Analogues
  • Assay For Cardiac Troponin Autoantibodies
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Alpha-Synuclein Antibodies
  • Anti-Aβ Globulomer 5f7 Antibodies
  • Antibodies And Chimeric Antigen Receptors Specific For Cd19
  • Human Anti-Pd-1, Pd-L1, And Pd-L2 Antibodies And Uses Therefor
  • Treatment And Prevention Of Ischemic Diseases And/Or Ischemic Tissue Damages
  • Garp-Tgf-Β 1 Igg Antibodies
  • Antibodies, Pharmaceutical Compositions And Methods
  • Targeted Therapeutics Based On Engineered Proteins That Bind Egfr
  • Genetic Engineered Antibody Fragment Having Preferential Binding For Rna Virus Epitopes, With Variable Light Or Heavy Chain Domains;Immunology; Veternary Medicine
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Anti-Sirpα Antibodies
  • Autoantibody Enhanced Immunoassays And Kits
  • Method For Selection And Production Of Tailor-Made Highly Selective And Multi-Specific Targeting Entities Containing At Least Two Different Binding Entities And Uses Thereof
  • Stable, Humanized, High Affinity Antibodies Against Carcinoembryonic Antigen, Therapy
  • Polyclonal Antibody Libraries
  • Methods Of Impairing Osteoclast Differentiation Using Antibodies That Bind Siglec-15
  • Serum Albumin-Binding Fibronectin Type Iii Domains
  • Assay For Measurement Of Antibodies Binding To A Therapeutic Monoclonal Antibody
  • Pathogenic West African Human Immunodeficiency Virus Type 2 (Hiv-2) Group F Isolate
  • Pax 5 Monoclonal Antibody
  • Therapeutic Peptides
  • Antibodies To Receptor Of Advanced Glycation End Products (Rage) And Uses Thereof
  • High Throughput Generation And Affinity Maturation Of Humanized Antibody
  • Peptide Targeting Of Inner Ear Cells
  • Antibody Produced By A Host Cell With A Deposit Number Of Atcc No. Pta-6516 Or Progeny Thereof, Or An Antigen-Binding Fragment Thereof, Said Antibody Specifically Binds To Carboxypeptidase M; Use In Diagnosing And Treating Various Human Cancers And Diseases That Express Kid31(Carboxypeptidase M)
  • Antibody Libraries
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Anti-Vegf Antibodies
  • Therapeutic Dll4 Binding Proteins
  • Compositions For Inhibiting Masp-2 Dependent Complement Activation
  • Decreasing Lactate Level And Increasing Polypeptide Production By Downregulating The Expression Of Lactate Dehydrogenase And Pyruvate Dehydrogenase Kinase
  • Use Of Dr6 And P75 Antagonists To Promote Survival Of Cells Of The Nervous System
  • Methods For Treating Chronic Sinusitis With Nasal Polyps By Administering An Il-4r Antagonist
  • Human Inkt Cell Activation Using Glycolipids
  • Methods Of Inhibiting Solid Tumor Growth By Administering Gpr49 Antibodies
  • Diagnostic Methods Based On Pregnancy-Associated Plasma Protein-A (Paap-A)
  • Proteomic Identification Of Antibodies
  • Method For Selection And Production Of Tailor-Made Highly Selective And Multi-Specific Targeting Entities Containing At Least Two Different Binding Entities And Uses Thereof
  • Prostate Cancer-Related Compositions, Methods, And Kits Based On Dna Macroarray Proteomics Platforms
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Anti-Baff Antibodies
  • Anti-Ige Antibodies And Method Of Improving Polypeptides
  • Anti-Cd33 Antibodies And Methods Of Use Thereof
  • Method To Improve Virus Filtration Capacity
  • Methods Of Generating Libraries And Uses Thereof
  • Antibodies Against The Rgm A Protein And Uses Thereof
  • Granulocyte-Macrophage Colony-Stimulating Factor (Gm-Csf) Neutralizing Antibodies
  • Immuno-Pet Imaging Of Antibodies And Immunoconjugates And Uses Therefor
  • Anti-Gp73 Monoclonal Antibodies And Methods Of Obtaining The Same
  • Compositions And Methods For The Therapy And Diagnosis Of Influenza
  • Anti-Bv8 Antibodies And Uses Thereof
  • Protein Scaffolds For Antibody Mimics And Other Binding Proteins
  • Microarrays And Uses Therefor
  • Antibodies That Bind Il-4 And/Or Il-13 And Their Uses
  • Antibodies To Insulin-Like Growth Factor I Receptor
  • Protein Purification Methods
  • Antibody Libraries
  • Neutralizing Monoclonal Antibodies To Respiratory Syncytial Virus
  • Cell Culture Compositions With Antioxidants And Methods For Polypeptide Production
  • Hepatocyte Lineage Cells
  • Production Of Anti-Self Antibodies From Antibody Segment Repertoires And Displayed On Phage
  • Anti-Htra1 Antibodies And Methods Of Use Thereof
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Thermus Thermophilus Slyd Fkbp Domain Specific Antibodies
  • Compositions And Methods Of Treating Muscle Atrophy And Myotonic Dystrophy
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Antibody-Active Agent Conjugates And Methods Of Use
  • Immunoassay Of Analytes In Samples Containing Endogenous Anti-Analyte Antibodies
  • Antibody Formulations
  • Proteomic Identification Of Antibodies
  • Cytotoxin Conjugated Immunoglobulin Specific To Tripeptide Sequence (N'-Trp-Pro-Ile-C') Of Carcinoembryonic Antigen For Use In Treatment And Prevention Of Cell Proliferative Disorders
  • Anti-Cxcr4 Antibodies And Antibody-Drug Conjugates
  • Evolution Of Trna Synthetases
  • Anti-Hepcidin Antibodies And Uses Thereof
  • Combination Therapies Employing Gitr Binding Molecules
  • Genetic Engineering
  • Methods Of Shuffling Polynucleotides
  • Methods Of Reducing Level Of One Or More Impurities In A Sample During Protein Purification
  • Identification Of Class I Mhc Associated Glycopertides As Targets For Cancer Immunotherapy
  • Compounds For Inducing Anti-Tumor Immunity And Methods Thereof
  • Dosage Regimes For The Administration Of An Anti-Cd19 Adc
  • Polynucleotides Encoding Antibodies Directed Against Amyloid-Beta Peptide
  • Compositions Comprising Purified Recombinant Il-13 Antibody
  • Methods And Compositions For Modulating Hepsin Activation Of Macrophage-Stimulating Protein
  • Anti-Activin A Antibodies And Uses Thereof
  • Methods Of Accelerating Or Improving Wound Healing Using Il-22 Fc Fusion Proteins
  • Fibronectin Based Scaffold Proteins Having Improved Stability
  • Composition And Method For The Diagnosis And Treatment Of Iron-Related Disorders
  • Fc Receptor Antibodies And Methods Of Use Thereof
  • Pyrrolobenzodiazepine Conjugates
  • Histone Deacetylases, And Uses Related Thereto
  • Anti-Ilt4 Antibodies And Antigen-Binding Fragments
  • Modulators
  • Methods For Treating Psoriasis By Administering An Antibody Which Binds An Epitope Of The P40 Subunit Of Il-12 And/Or Il-23
  • Pyrrolobenzodiazepine Conjugates
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Anti-Factor D Antibody Variant Conjugates And Uses Thereof
  • Stable Antibody Containing Compositions
  • Enrichment Method For Variant Proteins With Altered Binding Properties
  • Cd3-Targeting And Dll3-Targeting Multispecific Antigen-Binding Molecules And Uses Thereof
  • Human Antibodies That Bind The P40 Subunit Of Human Il-12 And Methods For Using The Same
  • Compositions Comprising Antibodies To Lingo Or Fragments Thereof
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Transgenic Animals Expressing Chimeric Antibodies For Use In Preparing Human Antibodies
  • Mutant Proteins And Methods For Selecting Them
  • Antibodies, Pharmaceutical Compositions And Methods
  • Antisense Oligonucleotides That Bind To Exon 51 Of Human Dystrophin Pre-Mrna
  • Methods Of Increasing Muscle Mass By Administration Of Activin Type 2 Receptor Antibodies
  • Constructs Specifically Recognizing Glypican 3 And Uses Thereof
  • Compound Bearing Beta-Galactoside-Introduced Self-Immolative Linker
  • Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Class Ii Human Histone Deacetylases, And Uses Related Thereto
  • Methods For Producing Polypeptides By Regulating Polypeptide Association
  • Compositions And Methods For Diagnosing And Treating Cancer
  • Screening Methods And Uses Thereof
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Il-1 Binding Proteins
  • Method Of Determining Virus Removal From A Sample Containing A Target Protein Using Activated Carbon
  • Antibody Libraries
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Anti-Vegf Antibodies
  • Anti-Cxcr4 Antibodies And Antibody-Drug Conjugates
  • Combination Therapies Employing Gitr Binding Molecules
  • Neuritogenic Peptides
  • Yeast Cell Surface Display Of Proteins And Uses Thereof
  • Combination Therapy With An Anti-Axl Antibody-Drug Conjugate
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Genetic Engineering; Crosslinking Polypeptide On Carrier
  • Protein Scaffolds For Antibody Mimics And Other Binding Proteins
  • Microarrays And Uses Therefor
  • Antibodies That Bind Il-4 And/Or Il-13 And Their Uses
  • Compositions Comprising Purified Recombinant Il-13 Antibody
  • Methods And Compositions For Modulating Hepsin Activation Of Macrophage-Stimulating Protein
  • Polynucleotides Encoding Antibodies Directed Against Amyloid-Beta Peptide
  • Antibodies To Insulin-Like Growth Factor I Receptor
  • Targeted Therapeutics Based On Engineered Proteins For Tyrosine Kinases Receptors, Including Igf-Ir
  • Anti-Ox40 Antibodies And Methods Of Use
  • That Specifically Binds To A Predetermined Antigen; Denaturing Polynucleotides Encoding Chain Determining Regions, Annealing And Incubating In Presence Of A Polymerase
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Monoclonal Antibodies Against Hmgb1
  • Antibodies That Bind To Repulsive Guidance Molecule A (Rgma)
  • Antibody To Gdf8 And Uses Thereof
  • Antibodies To A Non-Ligand Binding Region Of At Least Two Notch Receptors
  • Tweak Binding Antibodies
  • Compositions And Methods For The Therapy And Diagnosis Of Influenza
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Peptide Targeting Of Inner Ear Cells
  • Therapeutic Peptides
  • Antibodies To Receptor Of Advanced Glycation End Products (Rage) And Uses Thereof
  • High Throughput Generation And Affinity Maturation Of Humanized Antibody
  • Antibody Produced By A Host Cell With A Deposit Number Of Atcc No. Pta-6516 Or Progeny Thereof, Or An Antigen-Binding Fragment Thereof, Said Antibody Specifically Binds To Carboxypeptidase M; Use In Diagnosing And Treating Various Human Cancers And Diseases That Express Kid31(Carboxypeptidase M)
  • Evolution Of Trna Synthetases
  • Anti-Hepcidin Antibodies And Uses Thereof
  • Cytotoxin Conjugated Immunoglobulin Specific To Tripeptide Sequence (N'-Trp-Pro-Ile-C') Of Carcinoembryonic Antigen For Use In Treatment And Prevention Of Cell Proliferative Disorders
  • Antibody Libraries
  • Neutralizing Monoclonal Antibodies To Respiratory Syncytial Virus
  • Cell Culture Compositions With Antioxidants And Methods For Polypeptide Production
  • Protein Purification Methods
  • Hepatocyte Lineage Cells
  • Genetic Engineering
  • Endosialin-Binding Antibody
  • Methods For Inducing An Immune Response
  • Il-1 Binding Proteins
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Antibodies For The Treatment Of Synucleinopathy
  • Anti-Tissue Factor Antibodies And Compositions
  • Methods Of Treating Retinal Nerve Fiber Layer Degeneration With Monoclonal Antibodies Against A Retinal Guidance Molecule (Rgm) Protein
  • Method For Obtaining Antibodies
  • Antibodies And Chimeric Antigen Receptors Specific For Ror1
  • Therapeutic Composition For Treatment Of Glioblastoma
  • Enhanced Anti-Influenza Agents Conjugated With Anti-Inflammatory Activity
  • Borrelia Antigens
  • Antibodies To Madcam
  • Conjugated Biological Molecules, Pharmaceutical Compositions And Methods
  • Humanized Anti-Tgf-Beta Antibodies
  • Modified J-Chain
  • Human Monoclonal Antibodies To The Thyrotropin Receptor Which Act As Antagonists
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Alkynyl Sugar Analogs For Labeling And Visualization Of Glycoconjugates In Cells
  • Human Complementarity Determining Region (Cdr)-Grafted Antibody To Ganglioside Gm2
  • Anti-Neuropilin Antibodies And Methods Of Use
  • Method And Apparatus To Identify Vulnerable Plaques With Thermal Wave Imaging Of Heated Nanoparticles
  • Anti-Amyloid Antibodies And Uses Thereof
  • Anti-Her2 Glycoantibodies And Uses Thereof
  • Compositions And Methods Of Treating Muscle Atrophy And Myotonic Dystrophy
  • Ilt3 Binding Molecules And Uses Therefor
  • Rationally Designed, Synthetic Antibody Libraries And Uses Therefor
  • Borrelia Antigens
  • Methods For Administering Peptides For The Generation Of Effective C/S Conformation-Specific Antibodies To A Human Subject In Need Thereof
  • Production Of Anti-Self Antibodies From Antibody Segment Repertoires And Displayed On Phage
  • Monophosphorylated Lipid A Derivatives
  • Polynucleotides Encoding Notch1 Receptor Antibodies
  • Antibodies Against Signal-Regulatory Protein Alpha And Methods Of Use
  • Il-17 Binding Proteins
  • Using High-Performance Tangential-Flow Filtration (Hptff) To Isolate Preferential Polypeptides Such As Immunoadhesins; High Throughput Assay
  • Biomarker Of Asbestos Exposure And Mesothelioma
  • Method For The Detection Of A Binding Partner Of A Multispecific Binder
  • Treatment Of Protein Degradation Disorders
  • Compositions And Methods Relating To Universal Glycoforms For Enhanced Antibody Efficacy
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Methods To Increase Or Decrease Bone Density
  • Recombinant Production Of Mixtures Of Antibodies
  • Peptides Derived From Cytotoxicity Receptor Natural Killer Protein 44 Nkp44
  • Compositions And Methods Relating To Universal Glycoforms For Enhanced Antibody Efficacy
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Methods To Increase Or Decrease Bone Density
  • Production Of Heteromultimeric Proteins
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Anti-Sortilin Antibodies And Methods Of Use Thereof
  • Electromagnetically Tagged By Programming The Memory With Data Corresponding To Identifying Information Or Can Be Tagged By Imprinting The Matrix With Identifying Information; Data Storage; Sleeve Attached To A Container
  • 4-1bb Binding Molecules
  • Anti-Neuropilin Antibodies And Methods Of Use
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Method For Treating Il-8-Related Diseases
  • Method For In Vitro Molecular Evolution Of Protein Function
  • Peptide Targeting Of Inner Ear Cells
  • Engineered Cells For Adoptive Cell Therapy
  • Anti-Vegf Antibodies
  • Listeria-Based Adjuvants
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Methods For Modulating The Efficacy Of Nucleic Acid Based Therapies
  • Antibody Libraries
  • Anti-Garp Protein
  • Passive Immunization For Staphylococcus Infections
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Anti-Gitr Antibodies And Methods Of Use Thereof
  • Methods To Block Ige Binding To Cell Surface Receptors Of Mast Cells
  • Ilt3 Binding Molecules And Uses Therefor
  • Rationally Designed, Synthetic Antibody Libraries And Uses Therefor
  • Borrelia Antigens
  • Administering Monoclonal Antibody Or An Antigen-Binding Portion Thereof That Specifically Binds To And Activates Human Cd40; Gene Therapy; Nucleic Acid Coding Immunoglobulins; Anticancer Agents
  • Selection System
  • Human Inkt Cell Activation Using Glycolipids With Altered Glycosyl Groups
  • Anti-Cancer Antibodies, Combination Therapies, And Uses Thereof
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Purification Of Biological Molecules
  • High Affinity Antibodies Against Hmgb1 And Methods Of Use Thereof
  • Il-17 Binding Proteins
  • Using High-Performance Tangential-Flow Filtration (Hptff) To Isolate Preferential Polypeptides Such As Immunoadhesins; High Throughput Assay
  • Biomarker Of Asbestos Exposure And Mesothelioma
  • Methods For Treating Post-Surgical Pain By Administering An Anti-Nerve Growth Factor Antagonist
  • Anti-Factor D Antibodies
  • Polyethylenimine (Pei)-Polypeptide Conjugates And Methods Of Use Thereof
  • Bispecific Anti-Vegf/Anti-Ang-2 Antibodies And Their Use In The Treatment Of Ocular Vascular Diseases
  • Compositions And Methods For Treatment In Broad-Spectrum, Undifferentiated Or Mixed Clinical Applications
  • Producing Recombinant Nucleic Acid Using Cycles Of Hybridization, Chain Extension, And Denaturation; Then Transferring Into Cells For Recombining
  • Modified J-Chain
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Methods Of Treating Vascular Disease Using An Il-1beta Antibody
  • Methods Of Making Antibodies That Bind Polypeptides Involved In The Process Of Bone Remodeling
  • Anti-Theophylline Antibodies And Methods Of Use
  • Antibody Formulations
  • Anti-Tnf-Alpha Glycoantibodies And Uses Thereof
  • Nucleic Acid-Polypeptide Compositions And Methods Of Inducing Exon Skipping
  • Therapeutic Composition For Treatment Of Glioblastoma
  • Enhanced Anti-Influenza Agents Conjugated With Anti-Inflammatory Activity
  • Humanized Anti-Tgf-Beta Antibodies
  • Biomarker Composition Comprising Human Cytochrome P450 4a For Diagnosis Or Predicting Prognosis Of Hepatocellular Carcinoma
  • Methods For Affinity Maturation-Based Antibody Optimization
  • Nucleic Acid Encoding 10fn3 Polypeptide Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Carriers For Improved Drug Delivery
  • Neuropilin Antagonists
  • Anti-Gp73 Monoclonal Antibodies And Methods Of Obtaining The Same
  • Multispecific Antibodies
  • Direct Screening Method
  • Methods For Modular Synthesis Of N-Glycans And Arrays Thereof
  • Antibody Constructs For Egfrviii And Cd3
  • Methods And Compositions For Ameliorating Pancreatic Cancer
  • Monoclonal Antibody For Use In Prevention And Treatment Of Osteoarthritic And Surgical Pain; Immunotherapy
  • Biomarker Composition For Diagnosis Of Sepsis Using Hemoglobin Subunit Beta
  • Adjusting Affinity Of Polypeptide To Target Molecule By Identifying Aspartyl Residues Which Are Prone To Isomerization, Substituting Alternative Residues And Screening Resulting Mutants For Affinity Against Target Molecule
  • Immunological Targeting Of Pathological Tau Proteins
  • Pd-L1 Promoter Methylation In Cancer
  • Decreasing Lactate Level And Increasing Polypeptide Production By Down Regulating The Expression Of Lactate Dehydrogenase And Pyruvate Dehydrogenase Kinase
  • Compositions And Methods For The Therapy And Diagnosis Of Cytomegalovirus
  • Methods And Compounds For Lymphoma Cell Detection And Isolation
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Production Of Proteins In Glutamine-Free Cell Culture Media
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Libraries Of Modified Fibronectin Type Iii Tenth Domain-Containing Polypeptides
  • Antibodies And Chimeric Antigen Receptors Specific For Ror1
  • Antibody Producing Non-Human Mammals
  • Endoglin Antibodies
  • Borrelia Antigens
  • Method For Obtaining Antibodies
  • Antibodies To Madcam
  • Conjugated Biological Molecules, Pharmaceutical Compositions And Methods
  • Human Monoclonal Antibodies To The Thyrotropin Receptor Which Act As Antagonists
  • Yeast Cell Surface Display Of Proteins And Uses Thereof
  • Enhancing Activity Of Car T Cells By Co-Introducing A Bispecific Antibody
  • Stem Cell Factor Inhibitor
  • Methods For Treating Metabolic Syndrome Using Il-22 Fc Fusion Proteins
  • Synthetic Ligation Reassembly In Directed Evolution
  • Liquid Protein Formulations Containing 4-(3-Butyl-1-Imidazolio)-1-Butane Sulfonate (Bim)
  • Multiplex Protein Fractionation
  • Antibodies Specifically Binding To Masp-3 For The Treatment Of Various Diseases And Disorders
  • Zanamivir Phosphonate Congeners With Anti-Influenza Activity And Determining Oseltamivir Susceptibility Of Influenza Viruses
  • Antibodies To Lymphotoxin-Α
  • Antibodies That Bind Il-18 And Methods Of Inhibiting Il-18 Activity
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Alkynyl Sugar Analogs For Labeling And Visualization Of Glycoconjugates In Cells
  • Evolution Of Talens
  • Modulation Of Breast Cancer Growth By Modulation Of Xbp1 Activity
  • Method Of Predicting Animal Litter Size Using Protein Biomarkers Related With Fertility, And Method Of Predicting Animal Sperm Quality And Litter Size Using Chlortetracycline Staining
  • Identification Of Antigen Or Ligand-Specific Binding Proteins
  • Monoclonal Antibody That Binds Human Notch2 And Notch3
  • Internalizing Erbb2 Antibodies
  • Pyrrolobenzodiazepine Conjugates And Their Use For The Treatment Of Cancer
  • Antibody Drug Conjugates (Adcs) And Antibody Prodrug Conjugates (Apdcs) With Enzymatically Cleavable Groups
  • Anti-Complement Factor H Antibodies
  • Decreasing Lactate Level And Increasing Polypeptide Production By Downregulating The Expression Of Lactate Dehydrogenase And Pyruvate Dehydrogenase Kinase
  • Interleukin-13 Binding Proteins
  • Neuritogenic Peptides
  • Anti-Complement Factor H Antibodies
  • Methods Of Reducing Level Of One Or More Impurities In A Sample During Protein Purification
  • Nucleic Acid Molecules Encoding A Transmembrane Serine Protease 7, The Encoded Polypeptides And Methods Based Thereon
  • Anti-Mesothelin Immunoconjugates And Uses Therefor
  • Anti-Gitr Antibodies And Methods Of Use Thereof
  • Fucosidase From Bacteroides And Methods Using The Same
  • Therapeutic Vitamin D Conjugates
  • Ph Adjustment To Improve Thaw Recovery Of Cell Banks
  • Signal Biomarkers
  • Methods For Making Anterior Foregut Endoderm
  • Cd37 Immunotherapeutics And Uses Thereof
  • Combinatorial Libraries Of Conformationally-Constrained Cyclic Peptides For Use In Analysis Of Structure-Activity Relationships Between Proteins And Peptides; Drug Screening And Development
  • Glypican-3-Specific Antibody And Uses Thereof
  • Chimeric Retroviral Gag Genes And Screening Assays
  • Rtk-Bpb Specifically Binding To Rtk
  • Antibody Producing Non-Human Mammals
  • “Immune Checkpoint Intervention” In Cancer
  • Methods Of Inhibiting Growth Of A Colon Cancer Tumor In A Subject By Administering Monoclonal Antibodies To G Protein-Coupled Receptor 49 (Gpr49)
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Genetically Modified Non-Human Mammals And Cells
  • Isolation Of Antibody; Binding
  • Antibody/T-Cell Receptor Chimeric Constructs And Uses Thereof
  • Pdx1 Expressing Endoderm
  • Anti-Ngf Antibodies And Methods Using Same
  • Lrp-8 Binding Dual Variable Domain Immunoglobulin Proteins
  • Anti-Angiogenic Compounds
  • Synthetic Ligation Reassembly In Directed Evolution
  • Methods For Modifying Human Antibodies By Glycan Engineering
  • Colony Stimulating Bfcator Specific Monoclonal Antibody For Use In Diagnosis, Prevention And Treatment Of Infcetion, Cell Proliferative, Inflammatory, Autoimmune, Arthritic, Skin, Respiratory And Nervous System Disorders
  • Cell-Permeable Probes For Identification And Imaging Of Sialidases
  • Methods For Viral Inactivation And Other Adventitious Agents
  • R9detection Of Preferential Polypeptide In Sample; Obtain Sample Of Polypeptide, Incubate With Bacteriophage, Monitor Adjustment In Activity, Adjustment In Activity
  • Methods Of Evolving A Polynucleotides By Mutagenesis And Recombination
  • Gitr Antibodies And Methods Of Inducing Or Enhancing An Immune Response
  • Covalently Linked Antigen-Antibody Conjugates
  • Insulin Vitamin D Conjugates
  • Evolution Of Site-Specific Recombinases
  • Method For Selecting A Single Cell Expressing A Heterogeneous Combination Of Antibodies
  • Uses Of Wnt Polypeptides
  • Methods And Compositions For Polypeptide Engineering
  • Il-18 Binding Proteins
  • Methods Of Using Anti-Lap Antibodies
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Pectate Lyase Signal Sequence
  • Monoclonal Antibodies To Growth And Differentiation Factor 15 (Gdf-15)
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Combination Of A Pd-1 Antagonist And An Alk Inhibitor For Treating Cancer
  • Antibodies Specific To Human T-Cell Immunoglobulin And Itim Domain (Tigit)
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Anti-Siglec-15 Antibody
  • Therapeutic Dll4 Binding Proteins
  • Compounds
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Anti-Pcsk9 Antibodies, Formulations, Dosing, And Methods Of Use
  • Method For Screening Anti-Ligand Libraries For Identifying Anti-Ligands Specific For Differentially And Infrequently Expressed Ligands
  • Idiotypic Antibodies And Uses Thereof
  • Endoglin Antibodies
  • Method For Inhibiting The Immune Suppressive Function Of Human T Regulatory Cells By Administering An Anti-Garp Monoclonal Antibody
  • S. Pneumoniae Antigens
  • Transgenic Non-Human Animals Capable Of Producing Heterologous Antibodies
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Methods For Treating Osteoarthritis Pain By Administering A Nerve Growth Factor Antagonist And Compositions Containing The Same
  • Methods For Treating Conditions Associated With Masp-2 Dependent Complement Activation
  • Methods
  • Antibodies To Lymphotoxin-Α
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Liquid Protein Formulations Containing Thiamine
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Treating Allergic Disorder By Administering Cytokine Receptor Agonist Antibody Or Binding Fragment; Administered With An Anticarcinogen Or Growth Inhibitory Agent
  • Humanized C3 Animals
  • Anti-Gitr Antibodies And Methods Of Use Thereof
  • Lingo-1 Antagonists And Uses For Treatment Of Demyelinating Disorders
  • Protein Formulation
  • Monoclonal Antibody Recognizes A Thermostable Antigen From Bovine Blood; For Determining The Presence Of Bovine Blood In A Food Sample Or An Animal Feed Sample; Kits
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Methods And Compositions Comprising Purified Recombinant Polypeptides
  • Ionic Strength-Mediated Ph Gradient Ion Exchange Chromatography
  • Generation Of Binding Molecules
  • Production Of Heteromultimeric Proteins Using Mammalian Cells
  • Multiplex Protein Fractionation
  • Stem Cell Factor Inhibitor
  • Methods For Treating Metabolic Syndrome Using Il-22 Fc Fusion Proteins
  • Alkynyl Sugar Analogs For Labeling And Visualization Of Glycoconjugates In Cells
  • Peptides Specific For Hepatocellular Carcinoma Cells And Applications Thereof
  • Acetylenedicarboxyl Linkers And Their Uses In Specific Conjugation Of A Cell-Binding Molecule
  • Antibodies Specifically Binding To Masp-3 For The Treatment Of Various Diseases And Disorders
  • Zanamivir Phosphonate Congeners With Anti-Influenza Activity And Determining Oseltamivir Susceptibility Of Influenza Viruses
  • Antibodies To Lymphotoxin-Α
  • Anti-Ngf Antibodies And Methods Using Same
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Treating Allergic Disorder By Administering Cytokine Receptor Agonist Antibody Or Binding Fragment; Administered With An Anticarcinogen Or Growth Inhibitory Agent
  • Monoclonal Antibody Recognizes A Thermostable Antigen From Bovine Blood; For Determining The Presence Of Bovine Blood In A Food Sample Or An Animal Feed Sample; Kits
  • Methods And Means For The Production Of Ig-Like Molecules
  • Methods For Purifying A Target Protein From One Or More Impurities In A Sample
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Antibodies Specific For Native Prpsc
  • Wise Binding Agents And Epitopes
  • Antibody/T-Cell Receptor Chimeric Constructs And Uses Thereof
  • Cytotoxic Agents For Conjugation To A Cell Binding Molecule
  • Method For Enzymatic Production Of Decarboxylated Polyketides And Fatty Acids
  • Targeted Therapeutics Based On Engineered Proteins That Bind Egfr
  • Dp04 Polymerase Variants
  • Ionic Strength-Mediated Ph Gradient Ion Exchange Chromatography
  • Generation Of Binding Molecules
  • Humanized C3 Animals
  • Anti-Gitr Antibodies And Methods Of Use Thereof
  • Lingo-1 Antagonists And Uses For Treatment Of Demyelinating Disorders
  • Stable Protein Conformational Isomers And Methods For Producing And Isolating Such Isomers Are Disclosed. Methods Of Using Such Isomers, And Products And Compositions Comprising Such Isomers Are Also Disclosed.
  • Modulators
  • Methods Of Inducing Or Enhancing An Immune Response In A Subject By Administering Agonistic Gitr Binding Antibodies
  • Nfia In Glial Fate Determination, Glioma Therapy And Astrocytoma Treatment
  • Rnai Vitamin D Conjugates
  • Antibodies To Tgf-Β
  • Polysaccharide And Nucleic Acid Formulations Containing Viscosity-Lowering Agents
  • Stem Cell Factor Inhibitor
  • Methods Of Treating Cancer By Administering Igf-Ir Binding Molecules
  • Modified J-Chain
  • Methods And Compositions Comprising Purified Recombinant Polypeptides
  • Methods Of Modifying Antibodies For Purification Of Bispecific Antibodies
  • Peptides Specific For Hepatocellular Carcinoma Cells And Applications Thereof
  • Acetylenedicarboxyl Linkers And Their Uses In Specific Conjugation Of A Cell-Binding Molecule
  • Negative Selection And Stringency Modulation In Continuous Evolution Systems
  • Live Attenuated Vaccines
  • Isolation Of Antibody; Binding
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Nucleic Acid Molecules Encoding A Transmembrane Serine Protease 7, The Encoded Polypeptides And Methods Based Thereon
  • Anti-Mesothelin Immunoconjugates And Uses Therefor
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Methods For Treating Osteoarthritis Pain By Administering A Nerve Growth Factor Antagonist And Compositions Containing The Same
  • Methods For Treating Conditions Associated With Masp-2 Dependent Complement Activation
  • Methods
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Method For The Detection Of A Binding Partner Of A Multispecific Binder
  • Method Of Treating Auto-Inflammatory Syndromes With Il-1beta Antibodies Related To Canakinumab
  • Production Of Heteromultimeric Proteins Using Mammalian Cells
  • Methods For Treating Or Preventing Asthma By Administering An Il-4r Antagonist
  • Anti-Human Igg1 Antibody
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Methods For Making Anterior Foregut Endoderm
  • Cd37 Immunotherapeutics And Uses Thereof
  • Combinatorial Libraries Of Conformationally-Constrained Cyclic Peptides For Use In Analysis Of Structure-Activity Relationships Between Proteins And Peptides; Drug Screening And Development
  • Anti-Gitr Antibodies And Methods Of Use Thereof
  • Fucosidase From Bacteroides And Methods Using The Same
  • Therapeutic Vitamin D Conjugates
  • Ph Adjustment To Improve Thaw Recovery Of Cell Banks
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Therapeutic Dll4 Binding Proteins
  • Compounds
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Methods And Compositions Comprising Purified Recombinant Polypeptides
  • Anti-Complement Factor H Antibodies
  • Methods Of Reducing Level Of One Or More Impurities In A Sample During Protein Purification
  • Hepatocyte Lineage Cells
  • Methods Of Generating Libraries And Uses Thereof
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Anti-Pcsk9 Antibodies, Formulations, Dosing, And Methods Of Use
  • Method For Screening Anti-Ligand Libraries For Identifying Anti-Ligands Specific For Differentially And Infrequently Expressed Ligands
  • Antibodies To Tgf-Β
  • Selection Of Sequences With Desirable Binding Properties
  • Anti-Pdl1 Antibody Formulations
  • Use Of Tumor Fas Expression To Determine Response To Anti-Cancer Therapy
  • Nsp4 Inhibitors And Methods Of Use
  • Methods For Treating And/Or Preventing Graft-Versus-Host Disease And/Or Diffuse Alveolar Hemorrhage And/Or Veno-Occlusive Disease Associated With Hematopoietic Stem Cell Transplant
  • Humanized C5 Animals
  • Stabilizer For Protein Preparation Comprising Meglumine And Use Thereof
  • Human Anti-Pd-1, Pd-L1, And Pd-L2 Antibodies And Uses Therefor
  • Methods And Compositions For The Treatment Of Cancer
  • Antibodies That Bind Il-4 And/Or Il-13 And Their Uses
  • Inhibitors Of The Interaction Between Hmgb Polypeptides And Toll-Like Receptor 2 As Anti-Inflammatory Agents
  • Antibody Producing Non-Human Mammals
  • Cell Culture Compositions With Antioxidants And Methods For Polypeptide Production
  • Methods For Treating Post-Surgical Pain By Administering An Anti-Nerve Growth Factor Antagonist Antibody
  • Decreasing Lipid Absorption And Increasing Lipid And Fat Accumulation In Vacuoles In Intestinal Epithelial Cells By Administering An Anti-Hedgehog Antibody; Treating Obesity
  • Cell Engaging Binding Molecules
  • Monoclonal Anti-Alpha-Synuclein Antibodies For Preventing Tau Aggregation
  • Erbb3 Binding Antibody
  • Treatment For Inflammatory Bowel Disease With A Vcam-1/1gg Fusion Protein
  • Vegf/Dll4 Binding Agents And Uses Thereof
  • Il-I Binding Proteins
  • Method Of Treatment Comprising Purified Recombinant Il-13 Antibody
  • Anti-Her2 Glycoantibodies And Uses Thereof
  • Anti-Trem2 Antibodies And Methods Of Use Thereof
  • Supramolecular High Affinity Protein-Binding System For Purification Of Biomacromolecules
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Isolation And Identification Of Antigen- Or Ligand-Specific Binding Proteins
  • Glycan Conjugates And Use Thereof
  • Process For Preparing Antibody-Drug Conjugates With Improved Homogeneity
  • Deacetylase Inhibitors And Uses Thereof
  • Compositions And Methods For Detecting And Quantifying Host Cell Protein In Cell Lines And Recombinant Polypeptide Products
  • Detection Methods Employing Hcv Core Lipid And Dna Binding Domain Monoclonal Antibodies
  • Compositions And Methods For Treatment And Detection Of Cancers
  • Human Follicle-Stimulating Hormone Receptor (Fshr) Extracellular Domain Antibodies And Methods Of Use Thereof
  • Methods For Treating Inflammatory Bowel Disease
  • Anti-Vegf Antibodies
  • Preventing Cd28 Binding To B7 By Monovalent Fragments Antibody Called Cd28.3 Of Which Exhibit Sufficient Affinity For The Antigen So That They Can Be Used, In Vitro Or In Vivo, To Block The Cd28 Receptor Without Activation Of This Receptor; Autoimmune Diseases; Transplant Rejection
  • Antibodies Against Il-18r1 And Uses Thereof
  • Identifying Sclerostin Antagonist Via Abilty To Prevent Apoptosis; Treating Osteoporosis
  • Dual Specific Binding Proteins Directed Against Il-13 And Il-17
  • The Isolation And Production Of Catalytic Antibodies Using Phage Technology
  • Modified Factor Vii Polypeptides And Uses Thereof
  • Humanized Antibodies That Bind Lgr5
  • Antibodies Against Lif And Uses Thereof
  • For Therapy Of Condition In A Subject Characterized By Activation Of An Inflammatory Cytokine Cascade
  • Antigen Binding Complex Having Agonistic Activity And Methods Of Use
  • Il-17 Binding Proteins
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Hcv Core Lipid Binding Domain Monoclonal Antibodies
  • Anti-Lap Antibody Variants
  • Continuous Directed Evolution
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Dp04 Polymerase Variants
  • Dual Variable Domain Immunoglobulin And Uses Thereof
  • Endoglin Antibodies
  • Nucleic Acid Molecules Encoding A Transmembrane Serine Protease 10, The Encoded Polypeptides And Methods Based Thereon
  • Vectors And Genetically Engineered Immune Cells Expressing Metabolic Pathway Modulators And Uses In Adoptive Cell Therapy
  • Methods For Treating Pain By Administering A Nerve Growth Factor Antagonist And An Nsaid
  • Combination Therapies Comprising Anti-Erbb3 Agents
  • Markers Of Definitive Endoderm
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Antibody Against Carcionembryonic Antigen (Cea)
  • Method For Making Antibody Fc-Region Conjugates Comprising At Least One Binding Entity That Specifically Binds To A Target And Uses Thereof
  • High-Throughput Antibody Humanization
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Covalently Linked Polypeptide Toxin-Antibody Conjugates
  • Nucleic Acid Molecules Encoding A Humanized Antibody
  • Methods And Reagents For Isolating Biologically Active Peptides
  • Phagemids And Process Of Preparation
  • Continuous Directed Evolution
  • Methods For Treating Bone Cancer By Administering A Nerve Growth Factor Antagonist Antibody
  • Detection Methods Employing Hcv Core Lipid And Dna Binding Domain Monoclonal Antibodies
  • Tumor Necrosis Factor (Tnf) Receptor Superfamily (Tnfrsf) Receptor-Activating Antibody Fusion Proteins With Fcγr-Independent Agonistic Activity (Tnfrsf Receptor-Activating Antibody Fusion Proteins With Fcγr-Independent Agonistic Activity; Traaffiaa)
  • Prostaglandin E2 Dual Variable Domain Immunoglobulins And Uses Thereof
  • Dual Delivery System For Heterologous Antigens
  • Anti-Vegf Antibodies
  • Anti-Alpha2 Integrin Antibodies And Their Uses
  • Il-1 Binding Proteins
  • Method Of Generating Multiple Protein Variants And Populations Of Protein Variants Prepared Thereby
  • Recombinase Mutants
  • Recombinase Mutants
  • Il-17 Binding Proteins
  • Anti-Ox40 Antibodies And Anti-Gitr Antibodies
  • Methods And Compositions For The Treatment Of Cancer
  • Detection Of Antibody Variants; Mix Primers And Nucleotide Sequences Coding Antibody Or Antigen-Binding Segment, Perform Polymerase Chain Reaction And Generate Variant Nucleotide Sequences, Express Variants And Detect Binding Preferentials
  • Particle-Based Immunoassay Using A Pegylated Analyte-Specific Binding Agent
  • Antibodies Against Kidney Associated Antigen 1 And Antigen Binding Fragments Thereof
  • Anti-Rankl Antibodies And Methods Of Use
  • Enhanced Protein Purification Through A Modified Protein A Elution
  • Therapeutic Vitamin D Conjugates
  • Nsp4 Inhibitors And Methods Of Use
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Methods And Compositions For Cellular And Metabolic Engineering
  • Siglec 15 Antibodies In Treating Bone Loss-Related Disease
  • Calpain Modulators And Therapeutic Uses Thereof
  • Kits For Detecting Antibodies With Sensitivity To Preferential Antigens; Generate Solid Support, Join Antibodies To Support, Incubate With Antigen, Detect Bound Antigen, Recover Bound Antigen
  • Fast-Off Rate Serum Albumin Binding Fibronectin Type Iii Domains
  • Methods And Compositions For Delivery Of Molecules And Complexes To Reaction Sites
  • Pyrrolobenzodiazepine—Anti-Psma Antibody Conjugates
  • Antibodies That Bind To Mhc Class I Polypeptide-Related Sequence A
  • Methods Of Treating Hedgehog-Related Diseases With An Anti-Lgr5 Antibody
  • Stirred Tank Bioreactor
  • Continuous Directed Evolution
  • Transforming Microorganism And Monitoring Expression Of Heterologous Proteins On Cell Surface; Monitoring Protein-Protein Interactions And Identifying Modulators For Treating Autoimmune And Cell Proliferative Diseases
  • Fc Variants And Methods For Their Production
  • Class- And Isoform-Specific Hdac Inhibitors And Uses Thereof
  • Methods Of Treating Plaque Psoriasis
  • Directed Evolution Of Novel Binding Proteins
  • Antibodies Specific For Native Prpsc
  • Human Inkt Cell Activation Using Glycolipids
  • Cell Culture Media And Methods Of Antibody Production
  • Anti-Vla1 (Cd49a) Antibody Pharmaceutical Compositions
  • Multispecific Antigen Binding Proteins And Methods Of Use Thereof
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Immunoglobulins; Lymphokines; Hybridomas
  • Anti-Pdl1 Antibody Formulations
  • Human Anti-Pd-1, Pd-L1, And Pd-L2 Antibodies And Uses Therefor
  • Methods And Compositions For The Treatment Of Cancer
  • Antibodies That Bind Il-4 And/Or Il-13 And Their Uses
  • Decreasing Lipid Absorption And Increasing Lipid And Fat Accumulation In Vacuoles In Intestinal Epithelial Cells By Administering An Anti-Hedgehog Antibody; Treating Obesity
  • Nsp4 Inhibitors And Methods Of Use
  • Methods For Treating And/Or Preventing Graft-Versus-Host Disease And/Or Diffuse Alveolar Hemorrhage And/Or Veno-Occlusive Disease Associated With Hematopoietic Stem Cell Transplant
  • Humanized C5 Animals
  • Inhibitors Of The Interaction Between Hmgb Polypeptides And Toll-Like Receptor 2 As Anti-Inflammatory Agents
  • Antibody Producing Non-Human Mammals
  • Cell Culture Compositions With Antioxidants And Methods For Polypeptide Production
  • Specific Antibody-Drug-Conjugates (Adcs) With Ksp Inhibitors And Anti-Cd123-Antibodies
  • Therapeutic Dll4 Binding Proteins
  • Binding Domain-Immunoglobulin Fusion Proteins
  • Anti-Hemagglutinin Antibody Compositions And Methods Of Use Thereof
  • Anti-Gitr Antibodies And Methods Of Use Thereof
  • Photoresponsive Protein Hydrogels And Methods And Uses Thereof
  • Markers Of Definitive Endoderm
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Antibody Against Carcionembryonic Antigen (Cea)
  • Method For Making Antibody Fc-Region Conjugates Comprising At Least One Binding Entity That Specifically Binds To A Target And Uses Thereof
  • High-Throughput Antibody Humanization
  • Antibody Targeting Stem Cell Factor
  • Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Cell Culture Media And Methods Of Antibody Production
  • Anti-Vla1 (Cd49a) Antibody Pharmaceutical Compositions
  • Multispecific Antigen Binding Proteins And Methods Of Use Thereof
  • Evolution Of Talens
  • Markers Of Definitive Endoderm
  • Methods And Compositions For Cellular And Metabolic Engineering
  • Antibodies Directed Against Amyloid-Beta Peptide
  • Modified Tranposases For Improved Insertion Sequence Bias And Increased Dna Input Tolerence
  • Autoantibody Enhanced Immunoassays And Kits
  • Class- And Isoform-Specific Hdac Inhibitors And Uses Thereof
  • Methods Of Treating Plaque Psoriasis
  • Particle-Based Immunoassay Using A Pegylated Analyte-Specific Binding Agent
  • Antibodies Against Kidney Associated Antigen 1 And Antigen Binding Fragments Thereof
  • Therapeutic Vitamin D Conjugates
  • Nsp4 Inhibitors And Methods Of Use
  • Il-17 Binding Proteins
  • Anti-Ox40 Antibodies And Anti-Gitr Antibodies
  • Methods And Compositions For The Treatment Of Cancer
  • Detection Of Antibody Variants; Mix Primers And Nucleotide Sequences Coding Antibody Or Antigen-Binding Segment, Perform Polymerase Chain Reaction And Generate Variant Nucleotide Sequences, Express Variants And Detect Binding Preferentials
  • Combination Of Epigenetic Factors And Bispecific Compounds Targeting Cd33 And Cd3 In The Treatment Of Myeloid Leukemia
  • Synthetic Ligation Reassembly In Directed Evolution
  • Cd37 Immunotherapeutics And Uses Thereof
  • Antibodies To Insulin-Like Growth Factor I Receptor
  • Comprises Expression Vectors Coding Accumulation And Replication Of Chloroplast (Arc) Polypeptides For Altering Size, Morphhology And Number Of Plastids In Crop Plants
  • Protease Screening Methods And Proteases Identified Thereby
  • Methods Of Treating Gout Using Il-1beta Antibodies
  • Polypeptide Fusion Comprising Complementary Determining Regions For Use As Tool In Immunotherapeutic And/Or Diagnostics; Bioassay
  • Anti-Il1rap Antibodies And Methods Of Use Thereof
  • Aβ Conformer Selective Anti-Aβ Globulomer Monoclonal Antibodies
  • Production Of Anti-Self Antibodies From Antibody Segment Repertoires And Displayed On Phage
  • Monomeric And Dimeric Forms Of Adiponectin Receptor Fragments And Methods Of Use
  • Acetylenedicarboxyl Linkers And Their Uses In Specific Conjugation Of A Cell-Binding Molecule
  • Binding To Monoclonal Antibody; Antitumor Agents
  • Magneto-Motive Ultrasound Detection Of Magnetic Nanoparticles
  • Binding Domain-Immunoglobulin Fusion Proteins
  • High Concentration Protein Formulations With Reduced Viscosity
  • Human Monoclonal Antibodies To The Thyrotropin Receptor Which Act As Antagonists
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Methods And Compositions For Regulating Lymphocyte Activity
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Genus-Wide Chlamydial Peptide Vaccine Antigens
  • Autoantibody Enhanced Immunoassays And Kits
  • Ilt3 Binding Molecules And Uses Therefor
  • Multispecific Antibodies
  • Methods And Compositions For The Treatment Of Antibody Mediated Neuropathies
  • Dosage Regimes For The Administration Of An Anti-Cd25 Adc
  • Binding Domains Of Proteins Of The Repulsive Guidance Molecule (Rgm) Protein Family And Functional Fragments Thereof, And Their Use
  • Crystalline Anti-Human Il-12 Antibodies
  • Fully Human, Anti-Mesothelin Specific Chimeric Immune Receptor For Redirected Mesothelin-Expressing Cell Targeting
  • Methods For Treating Tweak-Related Conditions
  • Anti-Siglec-7 Antibodies And Methods Of Use Thereof
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Activator Of G Protein Signaling, Or ?Ags?; Recombinant Expression Vectors Containing A Nucleic Acid Molecule Of The Protein/Nucleic Acid
  • Immunoglobulin For Detecting Inflammation And Bacterial Infections In Mammals
  • Monoclonal Antibodies Against Amyloid Beta Protein And Uses Thereof
  • Multispecific Antigen-Binding Proteins
  • Chromatography Method For Quantifying A Nonionic Surfactant In A Composition Comprising The Non-Ionic Surfactant And A Polypeptide
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Identification And Cloning Of A Novel Neutralizing Human Monoclonal Antibody To The Respiratory Syncytial Virus. The Invention Provides Such Antibodies, Fragments Of Such Antibodies Retaining Rsv-Binding Ability, Chimeric Antibodies
  • Histone Deacetylases, And Uses Related Thereto
  • Producing Nucleic Acid Fragments Or Polynucleotides Conferring Desired Phenotype Which Encodes Mutant Proteins Via Repeated Cycles Of In Vitro Or In Vivo Recombination (Mutagenesis, Shuffling, And Selection)
  • Generation Of Binding Molecules
  • High Throughout Sequencing Of Paired Vh And Vl Transcripts From B Cells Secreting Antigen-Specific Antibodies
  • Composition And Method For The Diagnosis And Treatment Of Iron-Related Disorders
  • Anti-Pdgf-C Antibodies
  • Binding Compounds Of Penicillin Binding Protein 2 A
  • Type Ii Transmembrane Serine Protease (Mtsp) As A Single Chain; Anticancer Agents
  • Comprising A Variable Heavy (Vh) Domain That Has Non-Human Hypervariable Region Residues Incorporated Into A Human Vh Domain, Said Variable Domain Comprising A Framework Region (Fr) Substitution; Anticarcinogenic Agents, Angiogenesis Inhibitors; Immunoaffinity Chromatography, Immunoassay; Containers
  • Formulations With Reduced Oxidation
  • Method Of Treating Cancer By Administering A Monoclonal Antibody That Binds Human Notch2 And Notch3
  • Immunoglobulin Which Bind To Endothelial Growth Factor For Therapy Of Cell Proliferation; Antitumor Agents
  • Methods And Biomarkers For Predicting Efficacy And Evaluation Of An Ox40 Agonist Treatment
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Automatic Injection Device
  • Anti-Krs Monoclonal Antibody And Use Thereof
  • Liquid Pharmaceutical Formulations For Injection Comprising Yellow 5 Or Orange G And Uses Thereof
  • Antibodies That Bind To Tl1a And Their Uses
  • Elucidation Of Ion Exchange Chromatography Input Optimization
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • High Affinity Antibodies Against Hmgb1 And Methods Of Use Thereof
  • Antibodies Specific For Native Prpsc
  • Pentapeptide Compounds And Uses Related Thereto
  • B-Cell Reduction Using Cd37-Specific And Cd20-Specific Binding Molecules
  • Anti-Lap Antibody Variants
  • Kits For Detecting Antibodies With Sensitivity To Preferential Antigens; Generate Solid Support, Join Antibodies To Support, Incubate With Antigen, Detect Bound Antigen, Recover Bound Antigen
  • Dp04 Polymerase Variants
  • Continuous Directed Evolution
  • Tumor Necrosis Factor (Tnf) Receptor Superfamily (Tnfrsf) Receptor-Activating Antibody Fusion Proteins With Fcγr-Independent Agonistic Activity (Tnfrsf Receptor-Activating Antibody Fusion Proteins With Fcγr-Independent Agonistic Activity; Traaffiaa)
  • Binding Compounds Of Penicillin Binding Protein 2 A
  • Formulations With Reduced Oxidation
  • Method Of Treating Cancer By Administering A Monoclonal Antibody That Binds Human Notch2 And Notch3
  • Methods For Treating Tweak-Related Conditions
  • Crystalline Anti-Human Il-12 Antibodies
  • Fully Human, Anti-Mesothelin Specific Chimeric Immune Receptor For Redirected Mesothelin-Expressing Cell Targeting
  • Type Ii Transmembrane Serine Protease (Mtsp) As A Single Chain; Anticancer Agents
  • Comprising A Variable Heavy (Vh) Domain That Has Non-Human Hypervariable Region Residues Incorporated Into A Human Vh Domain, Said Variable Domain Comprising A Framework Region (Fr) Substitution; Anticarcinogenic Agents, Angiogenesis Inhibitors; Immunoaffinity Chromatography, Immunoassay; Containers
  • Monoclonal Antibodies Against Amyloid Beta Protein And Uses Thereof
  • Multispecific Antigen-Binding Proteins
  • Chromatography Method For Quantifying A Nonionic Surfactant In A Composition Comprising The Non-Ionic Surfactant And A Polypeptide
  • Histone Deacetylases, And Uses Related Thereto
  • Producing Nucleic Acid Fragments Or Polynucleotides Conferring Desired Phenotype Which Encodes Mutant Proteins Via Repeated Cycles Of In Vitro Or In Vivo Recombination (Mutagenesis, Shuffling, And Selection)
  • Generation Of Binding Molecules
  • High Throughout Sequencing Of Paired Vh And Vl Transcripts From B Cells Secreting Antigen-Specific Antibodies
  • Ilt3 Binding Molecules And Uses Therefor
  • Multispecific Antibodies
  • Methods And Compositions For The Treatment Of Antibody Mediated Neuropathies
  • Use Of Tumor Fas Expression To Determine Response To Anti-Cancer Therapy
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • B-Cell Reduction Using Cd37-Specific And Cd20-Specific Binding Molecules
  • Pentapeptide Compounds And Uses Related Thereto
  • Cdr-Modified Anti-Siglec-15 Antibody
  • Method Of Treating Asthma Using An Il-13 Antibody
  • Antibody Fragments Against The Insulin Receptor And Uses Thereof To Treat Hypoglycemia
  • Bispecific Antibodies
  • Anti-Hemagglutinin Antibody Compositions And Methods Of Use Thereof
  • Anti-Gitr Antibodies And Methods Of Use Thereof
  • Photoresponsive Protein Hydrogels And Methods And Uses Thereof
  • Methods Of Treating Kawasaki Disease Using Il-1beta Antibodies
  • Production Of Anti-Self Antibodies From Antibody Segment Repertories And Displayed On Phage
  • Method For Treating Joint Damage
  • Method For Producing And Obtaining Variable Domains Of Anti-Digoxin Monoclonal Antibody Fab Fragment Using The Molecular Biology Cloning Technique
  • Kid31 And Antibodies That Bind Thereto
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Polypeptides Comprising Antigen Binding Domains For Diagnosis, Prevention And Treatment Of Inflammation, Skin, Respiratory, Kidney, Cardiovascular, Nervous System And Pancreatic Disorder
  • Evolution Of New Metabolic Pathways And The Enhancement Of Bioprocessing Through Recursive Sequence Recombination Which Entails Performing Interative Cycles Of Recombination And Screening To Evolve Indivisual Genes, Whole Plasmids, Viruses
  • Constrained Immunogenic Compositions And Uses Therefor
  • Anti-Fzd10 Monoclonal Antibodies And Methods For Their Use
  • Akap84 And Its Use For Visualization Of Biological Structures
  • Histone Deacetylases, And Uses Related Thereto
  • Antibodies That Bind The Glutamate Ligand Binding Region Of Notch3
  • Humanized C3 Animals
  • Gdf-15 As A Diagnostic Marker To Predict The Clinical Outcome Of A Treatment With Immune Checkpoint Blockers
  • Antibodies For The Treatment Of Synucleinopathy
  • Antibodies Against Kidney Associated Antigen 1 And Antigen Binding Fragments Thereof
  • Polypeptides Capable Of Forming Antigen Binding Structures With Specificity For The Rhesus D Antigens, The Dna Encoding Them And The Process For Their Preparation And Use
  • Immunoglobulin Peptides Against Heated Bovine Blood
  • Modified Tranposases For Improved Insertion Sequence Bias And Increased Dna Input Tolerence
  • Antibody Targeting Stem Cell Factor
  • Evolution Of Talens
  • Markers Of Definitive Endoderm
  • Methods And Compositions For Cellular And Metabolic Engineering
  • Autoantibody Enhanced Immunoassays And Kits
  • Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
  • Antibodies Directed Against Amyloid-Beta Peptide
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use
  • Il-1 Binding Proteins
  • Antibodies; Immunohistochemistry; Rna Interference; Gene Expression Inhibition
  • Polymerase Enzyme Substrates With Protein Shield
  • Methods For Identifying Inhibitors Of Vascular Injury
  • Production Of Proteins In Glutamine-Free Cell Culture Media
  • Pichia Pastoris Formate Dehydrogenase And Uses Therefor
  • Human Antibodies That Bind Human Madcam
  • Methods For Inducing An Immune Response By Inhibition Of Nonsense Mediated Decay
  • Anti-Fgfr2/3 Antibodies And Methods Using Same
  • Transglutamine Tag For Efficient Site-Specific Bioconjugation
  • Monoclonal Antibody Produced By Hybridoma With Idac Accession Number 180706-02; Competitive Binding Of Monoclonal Antibody, Humanized-, Chimeric- Or Cancerous Disease Modifying Antibodies (Cdmab) With Tissue Sample Induces Cytotoxicity; Anticarcinogenic, Antitumor, And Antimetastasis Agents; Diagnosis
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Antibodies Against Lif And Uses Thereof
  • Rationally Designed, Synthetic Antibody Libraries And Uses Therefor
  • Monophosphorylated Lipid A Derivatives
  • Gpcr-Bpb Specifically Binding To Gpcr
  • Pyrrolobenzodiazepine-Anti-Cd22 Antibody Conjugates
  • Anti-Ige Antibodies
  • Method For Treating Gram Positive Septicemia
  • Charged Linkers And Their Uses For Conjugation
  • Generation Of Modified Polymerases For Improved Accuracy In Single Molecule Sequencing
  • Nucleic Acids Coding For Antibodies Against Human Il-21 Receptor And Uses Therefor
  • Chagasin-Based Scaffold Compositions, Methods, And Uses
  • Definitive Endoderm
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Antibodies Against N-Acetylglucosamine And N-Acetyl-Galactosamine
  • Biomarker Composition Comprising Nox4 For Diagnosis Or Predicting Prognosis Of Hepatocellular Carcinoma
  • Antibodies Recognizing A Carbohydrate Containing Epitope On Cd-43 And Cea Expressed On Cancer Cells And Methods Using Same
  • Cytotoxicity-Inducing Theraputic Agent
  • Anti-Bv8 Antibodies And Uses Thereof
  • Comprising A Variant Heavy Chain Variable Framework Domain And Complementary Determining Regions; Useful For Identifying Novel Polypeptides, Antibody, Antibody Fragments, And Antibody Variable Domains That May Be Used Therapeutically Or As Reagents
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Taurine Supplemented Cell Culture Medium And Methods Of Use
  • Method For In Vitro Molecular Evolution Of Protein Function
  • Anti-Il-12/Il-23 Antibodies
  • Compositions And Methods For Treatment And Detection Of Cancers
  • Insulin Vitamin D Conjugates
  • Antibodies To M-Csf
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Therapeutic Dll4 Binding Proteins
  • Cxc-Chemokine Antagonists Isolated From Rhipicephalus Sanguineus
  • Pharmacokinetic Modulation And Compositions For Modified Fn3 Polypeptides
  • Anti-Cd33 Antibodies And Methods Of Use Thereof
  • Monophosphorylated Lipid A Derivatives
  • Anti-Bv8 Antibodies And Uses Thereof
  • Anti-Fgfr2/3 Antibodies And Methods Using Same
  • Transglutamine Tag For Efficient Site-Specific Bioconjugation
  • Monoclonal Antibody Produced By Hybridoma With Idac Accession Number 180706-02; Competitive Binding Of Monoclonal Antibody, Humanized-, Chimeric- Or Cancerous Disease Modifying Antibodies (Cdmab) With Tissue Sample Induces Cytotoxicity; Anticarcinogenic, Antitumor, And Antimetastasis Agents; Diagnosis
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/352624a0

    DOI

    http://dx.doi.org/10.1038/352624a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021945431

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1907718


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