Making antibody fragments using phage display libraries View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-08

AUTHORS

Tim Clackson, Hennie R. Hoogenboom, Andrew D. Griffiths, Greg Winter

ABSTRACT

To by-pass hybridoma technology and animal immunization, we are trying to build antibodies in bacteria by mimicking features of immune selection1. Recently we used fd phage2 to display antibody fragments fused to a minor coat protein3,4, allowing enrichment of phage with antigen3. Using a random combinatorial library of the rearranged heavy (VH) and kappa (Vk) light chains5– from mice immune to the hapten 2-phenyloxazol-5-one (phOx), we have now displayed diverse libraries of antibody fragments on the surface of fd phage. After a single pass over a hapten affinity column, fd phage with a range of phOx binding activities were detected, at least one with high affinity (dissociation constant, Kd = 10-8 M). A second pass enriched for the strong binders at the expense of the weak. The binders were encoded by V genes similar to those found in anti-phOx hybridomas but in promiscuous combinations (where the same V gene is found with several different partners). By combining a promiscuous VH or VK gene with diverse repertoires of partners to create hierarchical libraries, we elicited many more pairings with strong binding activities. Phage display offers new ways of making antibodies from V-gene libraries, altering V-domain pairings and selecting for antibodies with good affinities. More... »

PAGES

624-628

Journal

TITLE

Nature

ISSUE

6336

VOLUME

352

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  • Automated Sorting System For Matrices With Memory
  • Reactive Labelling Compounds And Uses Thereof
  • Immunoassay System Simplifies Diagnosis Of Rickettsia; Sequenced And Cloned Gene Expressing The Major Surface Protein 5 Used As Immunogenic And Diagnostic Test Antigen; Genetic Engineering And Expression
  • Charged Linkers And Their Uses For Conjugation
  • Antibodies To Vla-1
  • Antibodies To M-Csf
  • A Shuffling Method Of Nucleic Acids For Obtaining Desired Phenotypic Properties By Producing Fragments Of Corresponding Nucleic Acids, One Containing A Codon Altered Sequence; By Hybridizing, Amplifying And Screening The Population
  • Multimers, Tetramers & Octamers
  • Anti-B7-H4 Antibodies And Immunoconjugates
  • Treatment Of Septicemia
  • Methods For Producing Polypeptides By Regulating Polypeptide Association
  • Antibodies To C-Met
  • Method Of Treating Type 1 Diabetes By Administering Nkp46 Polypeptide
  • Method For Chromatography Reuse
  • Polymerase Enzyme Substrates With Protein Shield
  • Assay For Cardiac Troponin-T (Ctnt)
  • Optimized Variants Of Anti-Vegf Antibodies And Methods Of Treatment Thereof By Reducing Or Inhibiting Angiogenesis
  • Nucleic Acid-Polypeptide Compositions And Methods Of Inducing Exon Skipping
  • Constant Chain Modified Bispecific, Penta- And Hexavalent Ig-M Antibodies
  • Antibody Formulations
  • Methods Of Screening For Sortilin Binding Antagonists
  • Antibody Constructs For Dll3 And Cd3
  • Nucleic Acids Encoding Anti-Siglec-15 Antibodies
  • Wise Binding Agents And Epitopes
  • 4-1bb Binding Molecules
  • Antibodies Recognizing A Carbohydrate Containing Epitope On Cd-43 And Cea Expressed On Cancer Cells And Methods Using Same
  • Antibody Drug Conjugates (Adcs) With Kinesin Spindel Protein (Ksp)
  • High-Affinity Anti-Mertk Antibodies And Uses Thereof
  • Serum Albumin Binding Molecules
  • Anti-Vegf Antibodies
  • Method Of Screening For Anti-Garp Antibodies
  • Use Of Anti-Endoglin Antibodies For Treating Ocular Fibrosis
  • Antibodies Specific For Native Prpsc
  • Reaction-Based Selection For Expression Of And Concentration Of Catalytic Moieties
  • Serum Albumin Binding Molecules
  • Extracellular Matrix Metalloproteinase Inducer (Emmprin) Peptides And Binding Antibodies
  • Anti-Cd26 Antibodies And Methods Of Use Thereof
  • Anti-O1 Antibodies And Uses Thereof
  • Antibodies To Tgf-Β
  • Antibodies That Bind Il-4 And/Or Il-13 And Their Uses
  • Methods For Identifying Factors For Differentiating Definitive Endoderm
  • Cation Exchange Chromatography Methods
  • Genetic Engineered Antibody Or Antigen Binding Segment That Is Capable Of Binding To Interleukins And Altering The Conformation Structure, Used For Treating Diseases Involving Immune And Inflammatory Responses
  • Prognosis Of Nephritis By Determination Of Presence Of Immunoglobulin G Antibodies Cross-Reactive With Antibodies To Double Stranded Dna And Denatured Anti-A And D Snrnp Proteins In A Lupus Patient
  • Methods For Treating Pain By Administering A Nerve Growth Factor Antagonist And An Nsaid And Compositions Containing The Same
  • Use Of Caprylic Acid Precipitation For Protein Purification
  • Compositions And Methods For The Therapy And Diagnosis Of Cytomegalovirus Infections
  • Kinase Specific Immunoglobulins For Prevention And Treatment Of Cell Proliferative Disorders
  • Covalently Linked Helicar-Anti-Helicar Antibody Conjugates And Uses Thereof
  • Method Of Inhibiting Acute Complement Mediated Cytotoxicity With Anti-Idiotypic Antibodies
  • Diagnostic And Prognostic Methods For Cardiovascular Diseases And Events
  • Internalizing Erbb2 Antibodies
  • Specific Binding Molecules For Scintigraphy, Conjugates Containing Them And Therapeutic Method For Treatment Of Angiogenesis
  • Compounds For Inducing Anti-Tumor Immunity And Methods Thereof
  • Trem2 Cleavage Modulators And Uses Thereof
  • Nucleic Acid Molecules Encoding For Bace1 Antibodies
  • Polymerase Enzyme Substrates With Protein Shield
  • Methods Of Treating Cancer Using Pd-1 Axis Binding Antagonists And Mek Inhibitors
  • Anti-Htra1 Antibodies And Methods Of Use Thereof
  • Anti-Trem2 Antibodies And Methods Of Use Thereof
  • Binding Polypeptides And Uses Thereof
  • Serum Albumin-Binding Fibronectin Type Iii Domains
  • Structural Isomers Of Sc(Fv)2
  • Antibodies Specific For Cd3 And Uses Thereof
  • Compositions And Methods Of Use For Antibodies Of Dickkopf-1
  • Nucleic Acid-Polypeptide Compositions And Methods Of Inducing Exon Skipping
  • Multivalent And Multiepitopic Antibodies Having Agonistic Activity And Methods Of Use
  • Stem Cell Factor Inhibitor
  • Antibodies Recognizing A Carbohydrate Containing Epitope On Cd-43 And Cea Expressed On Cancer Cells And Methods Using Same
  • Human Serum Albumin Linkers And Conjugates Thereof
  • High Affinity Antibodies Against Hmgb1 And Methods Of Use Thereof
  • Depth Filters For Disposable Biotechnological Processes
  • High Affinity Antibodies Against Hmgb1 And Methods Of Use Thereof
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Histone Deacetylases, And Uses Related Thereto
  • Antibodies Of The Ed-B Domain Of Fibronectin, Their Construction And Uses
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Selecting And Isolating A Subpopulation Of Viruses Or Organisms Which Express Suface-Bound Catalytic Moiety Such As A Catalytic Antibody Based On A Reaction
  • Anti-Ngf Antibodies And Methods Using Same
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Stable Igg4 Based Binding Agent Formulations
  • Enhancement Of Antibody-Mediated Immune Responses
  • Formulations Useful In The Treatment Of Proliferative Diseases Affecting The Respiratory Tract
  • Humanized Anti-Tau(Ps422) Antibody Brain Shuttles And Use Thereof
  • Methods Of Generating Libraries And Uses Thereof
  • Antibodies Recognizing A Carbohydrate Containing Epitope On Cd-43 And Cea Expressed On Cancer Cells And Methods Using Same
  • Protein Scaffolds For Antibody Mimics And Other Binding Proteins
  • High Concentration Antibody And Protein Formulations
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Hmg1 Antibody For Treating Inflammatory Conditions
  • Combination Therapies Using Cdk Inhibitors
  • Screening
  • Anti-Htra1 Antibodies And Methods Of Use
  • Method For The Treatment Of Amyloidoses
  • Treatment Of Tumors Using Specific Anti-L1 Antibody
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Methods And Compositions For The Treatment Of Cancer
  • Multispecific Antibodies
  • Methods For Detecting Protein Binding Sequences And Tagging Nucleic Acids
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Targeting Capn9/Capns2 Activity As A Therapeutic Strategy For The Treatment Of Myofibroblast Differentiation And Associated Pathologies
  • Antibody Constructs For Flt3 And Cd3
  • Antibodies To Human Programmed Death Receptor Pd-1
  • Recombining Non-Identical Nucleic Acids Having Plurality Of Intron And Exon Splicing Frames; Generating Combinatorial Library; Mutagenesis Cycles
  • Human Anti-Pd-1 Antibodies And Uses Therefor
  • Amyloid-Beta Binding Proteins
  • Recombining Non-Identical Nucleic Acids Having Plurality Of Intron And Exon Splicing Frames; Generating Combinatorial Library; Mutagenesis Cycles
  • Human Anti-Pd-1 Antibodies And Uses Therefor
  • Amyloid-Beta Binding Proteins
  • Methods For Increasing Definitive Endoderm Production
  • Protease Screening Methods And Proteases Identified Thereby
  • Bacteriophage Displaying Aβ Epitopes And Method Of Use
  • Genetic Engineering; Hybrids; Amplification
  • Screening Methods
  • Cytotoxicity-Inducing Therapeutic Agent
  • Compositions Comprising Purified Anti-Abeta Monoclonal Antibodies
  • Murine Antibody Display Library
  • Administration Of A Bispecific Construct Binding To Cd33 And Cd3 For Use In A Method For The Treatment Of Myeloid Leukemia
  • Antibodies To Insulin-Like Growth Factor I Receptor
  • Human Inkt Cell Activation Using Glycolipids With Altered Glycosyl Groups
  • Compositions For Inhibiting Masp-2 Dependent Complement Activation
  • Antibody Drug Conjugates (Adcs) Having Enzymatically Cleavable Groups
  • Pyrrolobenzodiazepine—Antibody Conjugates
  • Pharmaceutical Composition With Antibody That Binds To Heat Shock Protein 27(Hsp270) And Method For Promoting Wound Healing
  • Antibody Fragment Capable Of Modulating Multidrug Resistance And Compositions And Kits And Methods Using Same
  • Human Inkt Cell Activation Using Glycolipids With Altered Glycosyl Groups
  • Antibodies To Tgf-Beta
  • Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
  • Polynucleotides Encoding Optimized Variants Of Anti-Vegf Antibodies
  • Membrane Evaporation For Generating Highly Concentrated Protein Therapeutics
  • Anti-Lgr5 Antibodies And Immunoconjugates
  • Tf-Bpb Specifically Binding To Transcription Factor
  • Method For Using Boc/Cdo To Modulate Hedgehog Signaling
  • Combination Therapy Using Inhibitors Of Human Growth And Differentiation Factor 15 (Gdf-15) And Immune Checkpoint Blockers
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Monoclonal Antibody For Use In Prevention And Treatment Of Osteoarthritic And Surgical Pain; Immunotherapy
  • Methods Of Making And Using Multispecific Antibody Panels And Antibody Analog Panels
  • Simple And Efficient Method For In Vitro Mutagenesis And Recombination Of Polynucleotide Sequences Based On Based On Polymerase-Catalyzed Extension Of Primer Oligonucleotides
  • Antibody Formulations And Uses Thereof
  • Pyrrolobenzodiazepine Conjugates
  • Antibodies To The Human Prolactin Receptor
  • Icam-1 Binding Antibodies
  • Methods For Producing Antibody Libraries Using Universal Or Randomized Immunoglobulin Light Chains
  • Compositions And Methods For Binding Lysophosphatidic Acid
  • Ionic Strength-Mediated Ph Gradient Ion Exchange Chromatography
  • Method For The Treatment Of Inflammatory Disorders
  • Shuffling Polynucleotides By Incomplete Extension
  • Methods Of Treatment Using Human Antibodies That Bind Il-12
  • Compositions For Inhibiting Masp-2 Dependent Complement Activation
  • Endosialin-Binding Antibody
  • Production Of Anti-Self Bodies From Antibody Segment Repertories And Displayed On Phage
  • Amyloid Beta(1-42) Oligomers, Derivatives Thereof And Antibodies Thereto, Methods Of Preparation Thereof And Use Thereof
  • Amyloid-Beta Globulomer Antibodies
  • Antibodies Recognizing A Carbohydrate Containing Epitope On Cd-43 And Cea Expressed On Cancer Cells And Methods Using Same
  • Protein Scaffolds For Antibody Mimics And Other Binding Proteins
  • Methods Of Generating Libraries And Uses Thereof
  • Protein Recovery
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Distinction Of Infectious Virus Based On Molecular Biomarker And Neutralization Of Virus Causing Food Poisoning
  • Identification Of Antigen Or Ligand-Specific Binding Proteins
  • Agents, Uses And Methods For Treatment
  • Antibodies That Bind Polypeptides Involved In The Process Of Bone Remodeling
  • Antibodies To Tgf-Beta
  • Or Antibody Fragment Which Is Specific For And Binds Directly To The Ed B Oncofetal Domain Of Fibronectin; Diagnostic Kits For Cancer Treatment
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Methods For Preventing Or Treating Cardiovascular Conditions Using Il-22 Fc Fusion Proteins
  • Treatment Of Protein Degradation Disorders
  • Antibodies To High Mobility Group-1(Hmgb1) B-Box Polypeptides
  • Il-22 Fc Fusion Proteins
  • Anti-Kidney Associated Antigen 1 (Kaag1) Antibodies
  • Modified Phage For Displaying Post-Translationally Modified Proteins And Uses Thereof
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Methods For Screening For Binding Partners Of G-Protein Coupled Receptors
  • Modulation Of Nlgn4 Expression, Nk Cell Activity In Non-Alcoholic Fatty Liver Disease (Nafld)
  • High Concentration Antibody And Protein Formulations
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Treatment Of Protein Degradation Disorders
  • Polynucleotides Encoding Humanized Antibodies Against Ceacam1
  • Methods And Compositions For Ameliorating Pancreatic Cancer
  • Polypeptide Having An Antibody Antigen Binding Domain With High Affinity For Estradiol And Low Cross-Reactivity To Other Common Steroid Hormones; For Immunoassay Monitoring And Diagnosing Of In Vivo Hormone Levels And Related Diseases
  • Bipodal-Peptide Binder
  • Polypeptides Capable Of Forming Antigen Binding Structures With Specificity For The Rhesus D Antigens, The Dna Encoding Them And The Process For Their Preparation And Use
  • Anti-Mpl Antibodies
  • Diagnostic, Prognostic, And Monitoring Methods For Multiple Myeloma, Chronic Lymphocytic Leukemia, And B-Cell Non-Hodgkin Lymphoma
  • Used For The For The Medical Diagnosis And Treatment Of Alzheimer's Disease
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Methods For Inducing Or Enhancing An Immune Response By Administering Agonistic Glucocorticoid-Induced Tnfr-Family-Related Receptor (Gitr) Antibodies
  • Treatment Of Tumors Using Specific Anti-L1 Antibody
  • Biomarker For Replicative Senescence
  • Method To Detect Autoantibody Reactivity For Deamidated Insulin Autoantigen In Diabetes
  • Antibody Constructs For Flt3 And Cd3
  • Antibodies To Human Programmed Death Receptor Pd-1
  • Screening
  • Hmg1 Antibody For Treating Inflammatory Conditions
  • Combination Therapies Using Cdk Inhibitors
  • Methods For Identifying Inducers And Inhibitors Of Proteolytic Antibodies, Compositions And Their Uses
  • Monoclonal Antibody Or An Fab Fragment Capable Of Binding To Mouse Vascular Endothelial Cell Growth Factor (Vegf) And Human Vegf; Cancer, Diabetes Related Diseases, Age-Induced Macular Degeneration
  • Therapeutic Compositions Comprising Anti-Ige Antibodies And Immunosuppressive Agent
  • Isolated Nucleic Acids Encoding Anti-Sortilin Antibodies
  • Glycan Arrays On Ptfe-Like Aluminum Coated Glass Slides And Related Methods
  • Microarrays And Uses Therefor
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Antibodies To Lymphotoxin-Alpha
  • Neuropilin Antagonists
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Synthesis And Intermediates Of Pyrrolobenzodiazepine Derivatives For Conjugation
  • Host Cell Specific Binding Molecules Capable Of Neutralizing Viruses And Uses Thereof
  • Nucleic Acids Encoding Anti-Neonatal Fc Receptor (Fcrn) Antibodies
  • Anti-Gpr49 Monoclonal Antibodies
  • Method Of Treating Cancer By Administering Multivalent Fibronectin Based Scaffold Domain Proteins
  • Dna Reassembly After Random Fragmentation; Application To Mutagenesis Of Nucleic Acid Sequences By Recombination; Nucleic Acid Fragments Or Polynucleotides Encoding Mutant Proteins; Use For Directed Molecular Evolution Of
  • Methods For Modifying Human Antibodies By Glycan Engineering
  • Cells Expressing Chimeric Activating Receptors And Chimeric Stimulating Receptors And Uses Thereof
  • Treatment Of Protein Degradation Disorders
  • Methods Of Eliciting Broadly Neutralizing Antibodies Targeting Hiv-1 Gp41
  • Anti-B7-H4 Antibodies And Immunoconjugates
  • Anti-Epidermal Growth Factor Receptor (Egfr) Antibodies
  • Methods For Screening For Binding Partners Of G-Protein Coupled Receptors
  • Modulation Of Nlgn4 Expression, Nk Cell Activity In Non-Alcoholic Fatty Liver Disease (Nafld)
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Biological Materials And Uses Thereof
  • Modulators
  • Methods Of Treating Acute Pancreatitis Using Il-22 Fc Fusion Proteins
  • Human Complementarity Determining Region (Cdr)-Grafted Antibody To Ganglioside Gm2
  • Method For The Treatment Of Inflammatory Disorders
  • Monoclonal Antibodies, Compositions And Methods For Detecting Mucin-Like Protein (Mlp) As A Biomarker For Ovarian And Pancreatic Cancer
  • Methods And Compositions For Treatment Of Cancer
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Providing A Library Of Peptides Comprising A Trpzip Scaffold, Contacting The Library With The Bioactive Target Molecule; Selecting At Least One Peptide Capable Of Forming A Noncovalent Complex With The Bioactive Target Molecule From The Library; Isolating Peptide
  • Siglec-15 Antibodies In Treating Bone Loss-Related Disease
  • Antibody-Active Agent Conjugates And Methods Of Use
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Anti-Dll4/Vegf Dual Variable Domain Immunoglobulin And Uses Thereof
  • Bispecific Anti-Hapten/Anti-Blood Brain Barrier Receptor Antibodies, Complexes Thereof And Their Use As Blood Brain Barrier Shuttles
  • Transgenic Non-Human Animals For Producing Chimeric Antibodies
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Fast-Off Rate Serum Albumin Binding Fibronectin Type Iii Domains
  • High Affinity Human Antibodies To Tumor Antigens
  • Methods For Preventing Or Treating Cardiovascular Conditions Using Il-22 Fc Fusion Proteins
  • Treatment Of Protein Degradation Disorders
  • Antibodies To High Mobility Group-1(Hmgb1) B-Box Polypeptides
  • Il-22 Fc Fusion Proteins
  • Anti-Kidney Associated Antigen 1 (Kaag1) Antibodies
  • Polypeptides Capable Of Forming Antigen Binding Structures With Specificity For The Rhesus D Antigens, The Dna Encoding Them And The Process For Their Preparation And Use
  • Modified Phage For Displaying Post-Translationally Modified Proteins And Uses Thereof
  • Method For Treating Breast Cancer
  • Transgenic Animals Expressing Chimeric Antibodies For Use In Preparing Human Antibodies
  • Biological Materials And Uses Thereof
  • Methods For Treating Bone Cancer Pain By Administering A Nerve Growth Factor Antagonist Antibody
  • Performing Polymerse Chain Reaction Amplification To Generate A Population Of Partially Annealed Recombined Polynucleotides In Concatemeric Form; Introduce Concatemers Into Cells And Screen For Desired Functional Properties
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Bcma And Cd3 Bispecific T Cell Engaging Antibody Constructs
  • Antibodies Specific For Immunoglobulin-Like Transcript 3 (Ilt3) And Uses Thereof
  • Methods For Treating Chronic Sinusitis With Nasal Polyps By Administering An Il-4r Antagonist
  • Therapeutic Peptides
  • Compositions And Method For Treating Complement-Associated Conditions
  • Antibody Drug Conjugates (Adc) That Bind To Cd37 Proteins
  • Antibodies And Chimeric Antigen Receptors Specific For Cd19
  • Polynucleotides Encoding Bispecific Egfr/Igf-Ir Binding Molecules
  • Multimers, Tetramers And Octamers
  • Rationally Designed, Synthetic Antibody Libraries And Uses Therefor
  • Polymerases, Compositions, And Methods Of Use
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Preprimitive Streak And Mesendoderm Cells
  • Antibodies Specifically Binding To Masp-3 For The Treatment Of Various Diseases And Disorders
  • Methods And Compositions For Cellular And Metabolic Engineering
  • Comprises A Filamentous Bacteriophage Particle Displaying On Its Surface A Binding Molecule Which Has A Binding Domain Able To Bind Target Epitope Or Antigen; Genetic Engineering
  • Anti-Axl Antibodies And Methods Of Use
  • Il-17 Binding Proteins
  • Multi-Specific Fab Fusion Proteins Comprising A Cd3-Binding Fab Fragment With N-Terminal Fusion To Binding Domains And Methods Of Use
  • Treatment For Inflammatory Bowel Disease With A Fibronectin Polypeptide
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Treatment With Anti-Alpha2 Integrin Antibodies
  • Definitive Endoderm
  • Antibodies To Human Programmed Death Receptor Pd-1
  • Identification Of Antigen- Or Ligand-Specific Binding Proteins
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Anti-Pmel17 Antibodies And Immunoconjugates
  • Nucleic Acids Encoding Il-22 Fc Fusion Proteins
  • Method Of Treating Cancer By Administering Egfr And Egfr/Igfir Binding Molecules
  • High Throughput Generation And Affinity Maturation Of Humanized Antibody
  • Methods Of Inducing Or Enhancing An Immune Response In A Subject Having Cancer By Administering Gitr Antibodies
  • Capable Of Binding To Mouse Vascular Endothelial Cell Growth Factor (Vegf) And Human Vegf; Cancer, Diabetes Related Diseases, Edema, Inflammation
  • In Vitro Methods Of Producing And Identifying Immunoglobulin Molecules In Eukaryotic Cells
  • Method Of Treating Cancer By Administering An Anti-Lgr5 Monoclonal Antibody
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Human Antibodies That Bind Human Il-12
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Methods And Compositions For Assessing Responsiveness Of B-Cell Lymphoma To Treatment With Anti-Cd40 Antibodies
  • Hcv Antigen-Antibody Combination Assay And Methods And Compositions For Use Therein
  • Hmg1 Antibody For Treating Inflammatory Conditions
  • Methods For Inducing Or Enhancing An Immune Response By Administering Agonistic Gitr-Binding Antibodies
  • Eribulin-Based Antibody-Drug Conjugates And Methods Of Use
  • Methods Of Treating Inflammatory Bowel Disease Using Il-22 Fc Fusion Proteins
  • Alpha-Synuclein Antibodies
  • Anti-Aβ Globulomer 5f7 Antibodies
  • Recombinant Antibodies Against Hepatitis C Virus And Methods Of Obtaining And Using Same
  • Use Of Low Temperature And/Or Low Ph In Cell Culture
  • For Indentifying Receptor-Independent Activators Of Pheromone Response Pathway; Devised In Yeast Saccharomyces Cerevisiae; Activator Of G-Protein Signaling (Ags)
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Host Cell Specific Binding Molecules Capable Of Neutralizing Viruses And Uses Thereof
  • Assays For Detecting T Cell Immune Subsets And Methods Of Use Thereof
  • Antigen-Binding Proteins Targeting S. Aureus Orf0657n
  • Antibodies Against Kidney Associated Antigen 1 And Antigen Binding Fragments Thereof
  • Methods For Treating Conditions Associated With Masp-2 Dependent Complement Activation
  • Cancer Treatment With C-Met Antagonists And Correlation Of The Latter With Hgf Expression
  • Modified Polymerases For Improved Incorporation Of Nucleotide Analogues
  • Anti-T. Cruzi Antibodies And Methods Of Use
  • Treating Neurological Disorders
  • Assay For Cardiac Troponin Autoantibodies
  • Antibody-Drug Conjugates (Adcs) Of Ksp Inhibitors With Aglycosylated Anti-Tweakr Antibodies
  • Methods For Modulation Of Cholesterol Transport
  • Antibodies To Receptor For Advanced Glycation End Products (Rage) And Uses Thereof
  • Antibodies That Bind To Tl1a And Their Uses
  • Anti-Sortilin Antibodies, Uses And Methods For Treatment
  • Methods For Treating Progressive Multiple Sclerosis
  • Humanized Anti-Tau(Ps422) Antibodies And Methods Of Use
  • Polynucleotides Encoding Notch Receptor Antibodies
  • Method And Apparatus To Identify Vulnerable Plaques With Thermal Wave Imaging Of Heated Nanoparticles
  • Anti-Transferrin Receptor / Anti-Bace1 Multispecific Antibodies And Methods Of Use
  • Protease Screening Methods And Proteases Identified Thereby
  • Composition And Method For Diversification Of Target Sequences
  • Use Of Listeria Vaccine Vectors To Reverse Vaccine Unresponsiveness In Parasitically Infected Individuals
  • Methods Of Improving Vaccine Immunogenicity
  • Recombination Of Polynucleotide Sequences Using Random Or Defined Primers
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Bioassay; Drug Screening A Recombined Polynucleotides, Using Overlapping Nucleic Acids, Priming Polynucleotide Elongation Upon Hybridization To The Target Nucleic Acid; Mutagenesis, For Producing Mutant Enzyme, Antibodies, Therapeutic Proteins
  • Glycan Conjugates And Methods Of Use Thereof
  • For Expression In Host Cell; Includes Gene Coding For Repressor And An Associated Promoter, An Insertion Site For Insertional Deactivation Of Repressor, A Surface-Expressed Gene Encoding For Type I Fimbriae, And Operator; Automatic
  • Antibodies To Receptor Of Advanced Glycation End Products (Rage) And Uses Thereof
  • Immunoglobulin For Use In The Treatment Of Arthritis, Crohn's, Autoimmune, Inflammatory, Nervous System Skin And Diabetic Disorders
  • Notch1 Receptor Antibodies And Methods Of Treatment
  • High Affinity Tcr Proteins And Methods
  • Method Of Enhancing Proliferation Or Differentiation Of Hematopoietic Stem Cells Using Wnt Polypeptides
  • Assay For Diagnosis Of Cardiac Myocyte Damage
  • Recombinant Il-9 Antibodies And Uses Thereof
  • Method For Treating Joint Damage
  • Liquid Protein Formulations Containing Cimetidine
  • Anti-Epidermal Growth Factor Receptor (Egfr) Antibodies
  • Method Of Treating Lupus Nephritis
  • Method For Identifying A Subject At Risk Of Developing Heart Failure By Determining The Level Of Galectin-3 Or Thrombospondin-2
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Cell Engaging Binding Molecules
  • Anti-Ox40 Antibodies And Methods Of Use
  • Anti-Ngf Antibodies And Methods Using Same
  • Multispecific Fab Fusion Proteins And Use Thereof
  • Il-17 Binding Proteins
  • Immunoassay Methods And Reagents For Decreasing Nonspecific Binding
  • Bifunctional Histone Deacetylase Inhibitors
  • Vaccine Compositions And Methods For Restoring Nkg2d Pathway Function Against Cancers
  • Ultrapurified Dsba And Dsbc And Methods Of Making And Using The Same
  • Composition For Diagnosis Of Liver Metastasis Of Colorectal Cancer And The Use Thereof
  • Antibodies Specific To Human Poliovirus Receptor (Pvr)
  • Antibody Constructs For Cd70 And Cd3
  • Preparation Of Scfv Antibody Fragments
  • Antibodies To Madcam
  • High Throughput Sequencing Of Multiple Transcripts
  • Antibody Drug Conjugates Of Kinesin Spindel Protein (Ksp) Inhibitors With Antib7h3-Antibodies
  • Yeast Cell Surface Display Of Proteins And Uses Thereof
  • Dioxanes And Uses Thereof
  • Compositions And Methods For Treatment And Detection Of Cancers
  • Anti-Cxcr4 Antibodies And Antibody-Drug Conjugates
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Preparing Preferential Nucleotide Sequences Via Dna Repair And Heteroduplex Conversion; Directed Protein Evolution
  • Anti-Human Xcr1 Antibodies
  • Methods For Screening For Binding Partners Of G-Protein Coupled Receptors
  • Humanized Anti-Amyloid Antibody
  • Anti-Cd33 Antibodies And Methods Of Use Thereof
  • Activin Type 2 Receptor Antibodies
  • Methods For Inhibiting Angiogenesis In A Subject In Need Thereof
  • Biosynthetic Binding Proteins For Immunotargeting
  • Hpv-Specific Binding Molecules
  • Fusion Proteins For Modulating Regulatory And Effector T Cells
  • Calpain Modulators And Therapeutic Uses Thereof
  • Pentapetide Containing A Proline Amino Acid; Cytotoxic Agent
  • Polypeptide Does Not Contain A Vertebrate High Mobility Group Box Protein (Hmgb), That Inhibit The Release Of A Proinflammatory Cytokine; Treating Inflammatory Disease, Autoimmune Disease With Monoclonal Antibody Or Antigen-Binding Fragment
  • Method For Selecting A Single Cell Expressing A Heterogeneous Combination Of Antibodies
  • Anti-B7-H4 Antibodies And Immunoconjugates
  • Anti-5t4 Antibodies And Uses Thereof
  • Specific Antibody Drug Conjugates (Adcs) Having Ksp Inhibitors
  • Antibodies To M-Csf
  • Suppressor Cell Function Inhibition Following Listeria Vaccine Treatment
  • Antibodies That Specifcally Bind Sost And Wise Peptides
  • Antibodies Against The Human Fshr Extracellular Domain
  • Antibody/T-Cell Receptor Chimeric Constructs And Uses Thereof
  • Coiled Coil And/Or Tether Containing Protein Complexes And Uses Thereof
  • Anti-Transferrin Receptor Antibodies And Uses Thereof
  • Methods For Producing Members Of Specific Binding Pairs
  • Antibody Producing Non-Human Animals
  • Anti-Il-12/Il-23 Antibodies
  • Antibodies To Vla-1
  • Antibody Producing Non-Human Animals
  • Synthesis Of Hybrid Polynucleotide Molecules Using Single-Stranded Polynucleotide Molecules
  • Dual Specificity Antibodies And Methods Of Making And Using
  • Anti-Siglec-5 Antibodies And Methods Of Use Thereof
  • Modified Antibody Constant Region
  • Pharmaceutical Compositions Containing Sc(Fv)2
  • M-Csf-Specific Monoclonal Antibody And Uses Thereof
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use Thereof
  • Methods Of Making Human Primitive Ectoderm Cells
  • Ion Exchange Membrane Chromatography
  • Antibody Comprising A Heavy And Light Chain, Each Comprising Three Nonnaturally Occuring Chain Determining Regions; Antibody Specifically Binds To Human Antigen
  • Anti-Cd26 Antibodies And Methods Of Use Thereof
  • Binding Molecules With Modified J-Chain
  • Antibody Drug Conjugates (Adc) That Bind To Cd37 Proteins
  • Treatment With Anti-Alpha2 Integrin Antibodies
  • Definitive Endoderm
  • Multi-Specific Fab Fusion Proteins Comprising A Cd3-Binding Fab Fragment With N-Terminal Fusion To Binding Domains And Methods Of Use
  • Methods Of Treating Inflammatory Bowel Disease Using Il-22 Fc Fusion Proteins
  • Methods And Compositions For Assessing Responsiveness Of B-Cell Lymphoma To Treatment With Anti-Cd40 Antibodies
  • Hcv Antigen-Antibody Combination Assay And Methods And Compositions For Use Therein
  • Hmg1 Antibody For Treating Inflammatory Conditions
  • Eribulin-Based Antibody-Drug Conjugates And Methods Of Use
  • Method For Making Multispecific Antibodies Having Heteromultimeric And Common Components
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Preprimitive Streak And Mesendoderm Cells
  • High Throughput Generation And Affinity Maturation Of Humanized Antibody
  • Methods Of Inducing Or Enhancing An Immune Response In A Subject Having Cancer By Administering Gitr Antibodies
  • Capable Of Binding To Mouse Vascular Endothelial Cell Growth Factor (Vegf) And Human Vegf; Cancer, Diabetes Related Diseases, Edema, Inflammation
  • Nucleic Acids Encoding Il-22 Fc Fusion Proteins
  • Method Of Treating Cancer By Administering Egfr And Egfr/Igfir Binding Molecules
  • Polymerases, Compositions, And Methods Of Use
  • Comprises A Filamentous Bacteriophage Particle Displaying On Its Surface A Binding Molecule Which Has A Binding Domain Able To Bind Target Epitope Or Antigen; Genetic Engineering
  • Anti-Axl Antibodies And Methods Of Use
  • Il-17 Binding Proteins
  • Antibodies Specifically Binding To Masp-3 For The Treatment Of Various Diseases And Disorders
  • Methods And Compositions For Cellular And Metabolic Engineering
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Anti-Pmel17 Antibodies And Immunoconjugates
  • Liquid Protein Formulations Containing Cimetidine
  • Anti-Epidermal Growth Factor Receptor (Egfr) Antibodies
  • Method Of Treating Lupus Nephritis
  • Method For Identifying A Subject At Risk Of Developing Heart Failure By Determining The Level Of Galectin-3 Or Thrombospondin-2
  • Identification Of Antigen- Or Ligand-Specific Binding Proteins
  • Polynucleotides Encoding Bispecific Egfr/Igf-Ir Binding Molecules
  • Multimers, Tetramers And Octamers
  • Rationally Designed, Synthetic Antibody Libraries And Uses Therefor
  • Use Of Low Temperature And/Or Low Ph In Cell Culture
  • For Indentifying Receptor-Independent Activators Of Pheromone Response Pathway; Devised In Yeast Saccharomyces Cerevisiae; Activator Of G-Protein Signaling (Ags)
  • Recombinant Il-9 Antibodies And Uses Thereof
  • Method For Treating Joint Damage
  • Anti-Ox40 Antibodies And Methods Of Use
  • Methods For Treating Conditions Associated With Masp-2 Dependent Complement Activation
  • Cancer Treatment With C-Met Antagonists And Correlation Of The Latter With Hgf Expression
  • Antibody-Drug Conjugates (Adcs) Of Ksp Inhibitors With Aglycosylated Anti-Tweakr Antibodies
  • Treatment For Inflammatory Bowel Disease With A Fibronectin Polypeptide
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Anti-T. Cruzi Antibodies And Methods Of Use
  • Treating Neurological Disorders
  • Recombinant Antibodies Against Hepatitis C Virus And Methods Of Obtaining And Using Same
  • Host Cell Specific Binding Molecules Capable Of Neutralizing Viruses And Uses Thereof
  • Assays For Detecting T Cell Immune Subsets And Methods Of Use Thereof
  • Antibodies To Receptor For Advanced Glycation End Products (Rage) And Uses Thereof
  • Methods For Modulation Of Cholesterol Transport
  • Methods For Treating Progressive Multiple Sclerosis
  • Antibodies That Bind To Tl1a And Their Uses
  • Anti-Sortilin Antibodies, Uses And Methods For Treatment
  • Compositions And Methods Useful For Stabilizing Protein-Containing Formulations
  • Pyrrolobenzodiazepine Conjugates
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Anti-Factor D Antibody Variant Conjugates And Uses Thereof
  • Stable Antibody Containing Compositions
  • Enrichment Method For Variant Proteins With Altered Binding Properties
  • Antibodies Against Signal-Regulatory Protein Α And Methods Of Use
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Iga Multi-Specific Binding Molecules
  • Modified Polymerases For Improved Incorporation Of Nucleotide Analogues
  • Cd3-Targeting And Dll3-Targeting Multispecific Antigen-Binding Molecules And Uses Thereof
  • Human Antibodies That Bind The P40 Subunit Of Human Il-12 And Methods For Using The Same
  • Compositions Comprising Antibodies To Lingo Or Fragments Thereof
  • Methods Of Reducing Level Of One Or More Impurities In A Sample During Protein Purification
  • Anti-Bv8 Antibodies And Uses Thereof
  • Production Of Anti-Self Antibodies From Antibody Segment Repertoires And Displayed On Phage
  • Anti-Htra1 Antibodies And Methods Of Use Thereof
  • Anti-Gp73 Monoclonal Antibodies And Methods Of Obtaining The Same
  • Compositions And Methods For The Therapy And Diagnosis Of Influenza
  • Thermus Thermophilus Slyd Fkbp Domain Specific Antibodies
  • Proteomic Identification Of Antibodies
  • Method To Improve Virus Filtration Capacity
  • Methods Of Generating Libraries And Uses Thereof
  • Antibodies Against The Rgm A Protein And Uses Thereof
  • Granulocyte-Macrophage Colony-Stimulating Factor (Gm-Csf) Neutralizing Antibodies
  • Immuno-Pet Imaging Of Antibodies And Immunoconjugates And Uses Therefor
  • Antibody-Active Agent Conjugates And Methods Of Use
  • Immunoassay Of Analytes In Samples Containing Endogenous Anti-Analyte Antibodies
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Use
  • Bnp-Sp Antibodies
  • Composition For Diagnosis Of Korean Sacbrood Virus Infectious And Diagnostic Kit Containing Thereof
  • Compositions And Methods Of Treating Muscle Atrophy And Myotonic Dystrophy
  • Antigen-Binding Proteins Targeting S. Aureus Orf0657n
  • Methods For Inducing Or Enhancing An Immune Response By Administering Agonistic Gitr-Binding Antibodies
  • Methods Of Shuffling Polynucleotides
  • Identification Of Class I Mhc Associated Glycopertides As Targets For Cancer Immunotherapy
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Dosage Regimes For The Administration Of An Anti-Cd19 Adc
  • Compounds For Inducing Anti-Tumor Immunity And Methods Thereof
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Isolation And Purification Of Anti-Il-13 Antibodies Using Protein A Affinity Chromatography
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Cell Engaging Binding Molecules
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Human Antibodies That Bind Human Il-12
  • Antibodies Against Kidney Associated Antigen 1 And Antigen Binding Fragments Thereof
  • Isolated Polypeptide And Compositions Comprising Same
  • Isolation And Purification Of Anti-Il-13 Antibodies Using Protein A Affinity Chromatography
  • Amyloid Β(1-42) Oligomers, Derivatives Thereof And Antibodies Thereto, Methods Of Preparation Thereof And Use Thereof
  • Antibodies Against Signal-Regulatory Protein Α And Methods Of Use
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Iga Multi-Specific Binding Molecules
  • Modified Polymerases For Improved Incorporation Of Nucleotide Analogues
  • Bnp-Sp Antibodies
  • Composition For Diagnosis Of Korean Sacbrood Virus Infectious And Diagnostic Kit Containing Thereof
  • Signal Biomarkers
  • Antibodies To A Non-Ligand Binding Region Of At Least Two Notch Receptors
  • Tweak Binding Antibodies
  • Compositions And Methods For The Therapy And Diagnosis Of Influenza
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Neuritogenic Peptides
  • Transgenic Animals Expressing Chimeric Antibodies For Use In Preparing Human Antibodies
  • Mutant Proteins And Methods For Selecting Them
  • Antibodies, Pharmaceutical Compositions And Methods
  • Antisense Oligonucleotides That Bind To Exon 51 Of Human Dystrophin Pre-Mrna
  • Methods Of Increasing Muscle Mass By Administration Of Activin Type 2 Receptor Antibodies
  • Constructs Specifically Recognizing Glypican 3 And Uses Thereof
  • Compound Bearing Beta-Galactoside-Introduced Self-Immolative Linker
  • Yeast Cell Surface Display Of Proteins And Uses Thereof
  • Combination Therapy With An Anti-Axl Antibody-Drug Conjugate
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Il-1 Binding Proteins
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Screening Methods And Uses Thereof
  • Methods For Producing Polypeptides By Regulating Polypeptide Association
  • Compositions And Methods For Diagnosing And Treating Cancer
  • Method Of Determining Virus Removal From A Sample Containing A Target Protein Using Activated Carbon
  • Compositions And Methods For The Therapy And Diagnosis Of Cytomegalovirus
  • Class-And Isoform-Specific Hdac Inhibitors And Uses Thereof
  • Automatic Injection Device
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Monoclonal Antibody To Pd-L1
  • Endosialin-Binding Antibody
  • Methods For Inducing An Immune Response
  • Il-1 Binding Proteins
  • Gene Expression Markers And Treatment Of Multiple Sclerosis
  • Screening Nucleotide Sequence Libraries For Genes Coding Preferential Activities; Provide Cells Containing Library, Screen Cells And Detect Preferential Activity
  • Isolated Polypeptide And Compositions Comprising Same
  • Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Class Ii Human Histone Deacetylases, And Uses Related Thereto
  • Antibodies That Bind To Repulsive Guidance Molecule A (Rgma)
  • Antibody To Gdf8 And Uses Thereof
  • Genetic Engineering; Crosslinking Polypeptide On Carrier
  • Targeted Therapeutics Based On Engineered Proteins For Tyrosine Kinases Receptors, Including Igf-Ir
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Monoclonal Antibodies Against Hmgb1
  • Anti-Ox40 Antibodies And Methods Of Use
  • That Specifically Binds To A Predetermined Antigen; Denaturing Polynucleotides Encoding Chain Determining Regions, Annealing And Incubating In Presence Of A Polymerase
  • Compositions And Methods Useful For Stabilizing Protein-Containing Formulations
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Bcma And Cd3 Bispecific T Cell Engaging Antibody Constructs
  • Saccharide-Based Biomarkers And Therapeutics
  • Method For Treating Glioblastoma Or Glioma With Antibody Constructs For Egfrviii And Cd3
  • Isolation And Purification Of Anti-Il-13 Antibodies Using Protein A Affinity Chromatography
  • Human Antibodies That Bind Human Interleukin-12
  • Psma And Cd3 Bispecific T Cell Engaging Antibody Constructs
  • Anti-Siglec-7 Antibodies And Methods Of Use Thereof
  • Methods Of Treating Retinal Nerve Fiber Layer Degeneration With Monoclonal Antibodies Against A Retinal Guidance Molecule (Rgm) Protein
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Antibodies For The Treatment Of Synucleinopathy
  • Anti-Tissue Factor Antibodies And Compositions
  • Method For In Vitro Molecular Evolution Of Protein Function Involving The Use Of Exonuclease Enzyme And Two Populations Of Parent Polynucleotide Sequence
  • Method For Producing And Obtaining Variable Domains Of Anti-Digoxin Monoclonal Antibody Fab Fragment Using The Molecular Biology Cloning Technique
  • Monophosphorylated Lipid A Derivatives
  • Polynucleotides Encoding Notch1 Receptor Antibodies
  • Antibodies Against Signal-Regulatory Protein Alpha And Methods Of Use
  • Recombinant Production Of Mixtures Of Antibodies
  • Peptides Derived From Cytotoxicity Receptor Natural Killer Protein 44 Nkp44
  • Compositions And Methods For Detecting And Quantifying Host Cells Protein In Cell Lines And Recombinant Polypeptide Products
  • Methods And Reagents For Detecting Bioactive Lipids
  • Antibody Therapy Of Tumors
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Antibodies To C-Met
  • Aqueous Formulation Of A Humanized Anti-Vegf Antibody In A Buffer To Inhibit Vegf (Vascular Endothelial Growth Factor) Induced Angiogenesis;
  • Binds To (Acetylated) Low Density Lipoproteins; Genetically Engineered With Substitutions, Deletions, And Additions
  • Method For Screening Anti-Ligand Libraries For Identifying Anti-Ligands Specific For Differentially And Infrequently Expressed Ligands
  • Compositions And Methods Comprising Klk3 Or Folh1 Antigen
  • 5-Hydroxymethylcytosine In Human Cancer
  • Bispecific Egfr/Igfir Binding Molecules
  • Preparing Nucleotide Sequence Libraries In Vitro Using Polymerase Chain Reaction
  • Compositions For Detecting Complement Factor H (Cfh) And Complement Factor I (Cfi) Polymorphisms
  • Monoclonal Antibodies Against Amyloid Beta Protein And Uses Thereof
  • Cloning And Regulation Of An Endothelial Cell Protein C/Activated Protein C Receptor
  • Humanized C5 Animals
  • Dual-Specific Il-1Α/Il-1Β Antibodies
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Adjusting Antibodies Associated With Leucine Zippers; Exposeantibody To Protease, Incubate, Recover And Monitor For Deletion Of Leucine Zipper
  • Multimers For Viral Strain Evolution
  • Anti-Amyloid Antibodies And Uses Thereof
  • Anti-Her2 Glycoantibodies And Uses Thereof
  • Compositions And Methods Of Treating Muscle Atrophy And Myotonic Dystrophy
  • Alkynyl Sugar Analogs For Labeling And Visualization Of Glycoconjugates In Cells
  • Human Complementarity Determining Region (Cdr)-Grafted Antibody To Ganglioside Gm2
  • Method And Apparatus To Identify Vulnerable Plaques With Thermal Wave Imaging Of Heated Nanoparticles
  • Isolated Monoclonal Anti-Repulsive Guidance Molecule A Antibodies And Uses Thereof
  • Anti-Axl Antibodies And Methods Of Use
  • Treatment Of Protein Degradation Disorders
  • Method For In Vitro Molecular Evolution Of Protein Function Involving The Use Of Exonuclease Enzyme And Two Populations Of Parent Polynucleotide Sequence
  • Method For Producing And Obtaining Variable Domains Of Anti-Digoxin Monoclonal Antibody Fab Fragment Using The Molecular Biology Cloning Technique
  • Method For Treating Il-8-Related Diseases
  • Method For In Vitro Molecular Evolution Of Protein Function
  • Antibody To Gdf8 And Uses Thereof
  • Methods Of Increasing Progranulin Levels Using Anti-Sortilin Antibodies
  • Method Of Treating Auto-Inflammatory Syndromes With Il-1beta Antibodies Related To Canakinumab
  • Peptide Targeting Of Inner Ear Cells
  • Engineered Cells For Adoptive Cell Therapy
  • Anti-Vegf Antibodies
  • Biomarker Composition Comprising Txndc7 For Diagnosis Or Predicting Prognosis Of Hepatocellular Carcinoma
  • Passive Immunization For Staphylococcus Infections
  • Methods For Modulating The Efficacy Of Nucleic Acid Based Therapies
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Decreasing Lactate Level And Increasing Polypeptide Production By Downregulating The Expression Of Lactate Dehydrogenase And Pyruvate Dehydrogenase Kinase
  • Listeria-Based Adjuvants
  • Antibody Libraries
  • Anti-Garp Protein
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Administering Monoclonal Antibody Or An Antigen-Binding Portion Thereof That Specifically Binds To And Activates Human Cd40; Gene Therapy; Nucleic Acid Coding Immunoglobulins; Anticancer Agents
  • Selection System
  • Electromagnetically Tagged By Programming The Memory With Data Corresponding To Identifying Information Or Can Be Tagged By Imprinting The Matrix With Identifying Information; Data Storage; Sleeve Attached To A Container
  • Anti-Axl Antibodies And Methods Of Use
  • Isolated Monoclonal Anti-Repulsive Guidance Molecule A Antibodies And Uses Thereof
  • Multimers For Viral Strain Evolution
  • Humanized C5 Animals
  • Dual-Specific Il-1Α/Il-1Β Antibodies
  • Human Inkt Cell Activation Using Glycolipids With Altered Glycosyl Groups
  • 4-1bb Binding Molecules
  • Antibody Producing Non-Human Mammals
  • Endoglin Antibodies
  • Production Of Heteromultimeric Proteins
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Enhancing Activity Of Car T Cells By Co-Introducing A Bispecific Antibody
  • Yeast Cell Surface Display Of Proteins And Uses Thereof
  • Anti-Sortilin Antibodies And Methods Of Use Thereof
  • Adjusting Antibodies Associated With Leucine Zippers; Exposeantibody To Protease, Incubate, Recover And Monitor For Deletion Of Leucine Zipper
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Libraries Of Modified Fibronectin Type Iii Tenth Domain-Containing Polypeptides
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Nucleic Acid Encoding 10fn3 Polypeptide Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Carriers For Improved Drug Delivery
  • Neuropilin Antagonists
  • Anti-Gp73 Monoclonal Antibodies And Methods Of Obtaining The Same
  • Multispecific Antibodies
  • Anti-Glucosaminidase Passive Immunization For Staphylococcus Aureus Infections
  • Methods Of Treating Vascular Disease Using An Il-1beta Antibody
  • Methods Of Making Antibodies That Bind Polypeptides Involved In The Process Of Bone Remodeling
  • Anti-Theophylline Antibodies And Methods Of Use
  • Antibody Formulations
  • Methods And Reagents For Detecting Bioactive Lipids
  • Antibody Therapy Of Tumors
  • Nucleic Acid-Polypeptide Compositions And Methods Of Inducing Exon Skipping
  • Anti-Tnf-Alpha Glycoantibodies And Uses Thereof
  • Direct Screening Method
  • Compositions For Detecting Complement Factor H (Cfh) And Complement Factor I (Cfi) Polymorphisms
  • Compositions And Methods Comprising Klk3 Or Folh1 Antigen
  • 5-Hydroxymethylcytosine In Human Cancer
  • Bispecific Egfr/Igfir Binding Molecules
  • Preparing Nucleotide Sequence Libraries In Vitro Using Polymerase Chain Reaction
  • Cloning And Regulation Of An Endothelial Cell Protein C/Activated Protein C Receptor
  • Purification Of Biological Molecules
  • Method For Screening Anti-Ligand Libraries For Identifying Anti-Ligands Specific For Differentially And Infrequently Expressed Ligands
  • Monoclonal Antibodies Against Amyloid Beta Protein And Uses Thereof
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Antibodies To C-Met
  • Aqueous Formulation Of A Humanized Anti-Vegf Antibody In A Buffer To Inhibit Vegf (Vascular Endothelial Growth Factor) Induced Angiogenesis;
  • Binds To (Acetylated) Low Density Lipoproteins; Genetically Engineered With Substitutions, Deletions, And Additions
  • Production Of Proteins In Glutamine-Free Cell Culture Media
  • Immunological Targeting Of Pathological Tau Proteins
  • Pd-L1 Promoter Methylation In Cancer
  • Decreasing Lactate Level And Increasing Polypeptide Production By Down Regulating The Expression Of Lactate Dehydrogenase And Pyruvate Dehydrogenase Kinase
  • Compositions And Methods For The Therapy And Diagnosis Of Cytomegalovirus
  • Adjusting Affinity Of Polypeptide To Target Molecule By Identifying Aspartyl Residues Which Are Prone To Isomerization, Substituting Alternative Residues And Screening Resulting Mutants For Affinity Against Target Molecule
  • Biomarker Composition Comprising Human Cytochrome P450 4a For Diagnosis Or Predicting Prognosis Of Hepatocellular Carcinoma
  • Methods For Affinity Maturation-Based Antibody Optimization
  • Methods For Treating Post-Surgical Pain By Administering An Anti-Nerve Growth Factor Antagonist
  • Anti-Factor D Antibodies
  • Producing Recombinant Nucleic Acid Using Cycles Of Hybridization, Chain Extension, And Denaturation; Then Transferring Into Cells For Recombining
  • Methods And Compositions For Ameliorating Pancreatic Cancer
  • Compositions And Methods For Detecting And Quantifying Host Cells Protein In Cell Lines And Recombinant Polypeptide Products
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Anti-Gitr Antibodies And Methods Of Use Thereof
  • Methods To Block Ige Binding To Cell Surface Receptors Of Mast Cells
  • Anti-Cancer Antibodies, Combination Therapies, And Uses Thereof
  • High Affinity Antibodies Against Hmgb1 And Methods Of Use Thereof
  • Polyethylenimine (Pei)-Polypeptide Conjugates And Methods Of Use Thereof
  • Bispecific Anti-Vegf/Anti-Ang-2 Antibodies And Their Use In The Treatment Of Ocular Vascular Diseases
  • Compositions And Methods For Treatment In Broad-Spectrum, Undifferentiated Or Mixed Clinical Applications
  • Antibody Constructs For Egfrviii And Cd3
  • Monoclonal Antibody For Use In Prevention And Treatment Of Osteoarthritic And Surgical Pain; Immunotherapy
  • Biomarker Composition For Diagnosis Of Sepsis Using Hemoglobin Subunit Beta
  • Methods For Modular Synthesis Of N-Glycans And Arrays Thereof
  • Methods And Compounds For Lymphoma Cell Detection And Isolation
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Negative Selection And Stringency Modulation In Continuous Evolution Systems
  • Live Attenuated Vaccines
  • Antibodies Specific For Native Prpsc
  • Antibodies To Tgf-Β
  • Antibody Selection Methods Using Cell Surface Expressed Libraries
  • Pdx1 Expressing Endoderm
  • Anti-Cd33 Antibodies And Methods Of Use Thereof
  • Bace1 Antibodies
  • Antibodies To Lymphotoxin-Α
  • Protein Formulation
  • Antibody/T-Cell Receptor Chimeric Constructs And Uses Thereof
  • Monoclonal Antibodies To Growth And Differentiation Factor 15 (Gdf-15), And Uses Thereof For Treating Cancer Cachexia And Cancer
  • Modular Assembly Of Antibody Genes, Antibodies Prepared Thereby And Use
  • Antibodies To Prevent Tissue Rejection
  • Anti-Inflammatory Treatment Via Inhibition Of Endothelial Cell Kinesin Light Chain 1, Variant 1 (Klc1c)
  • Methods Of Reducing The Risk Of Experiencing A Cardiovascular (Cv) Event Or A Cerebrovascular Event In A Patient That Has Suffered A Qualifying Cv Event
  • Cc-Chemokine Binding Tick Proteins
  • Production Of Anti-Self Antibodies From Antibody Segment Repertoires And Displayed On Phage
  • Decreasing Lactate Level And Increasing Polypeptide Production By Downregulating The Expression Of Lactate Dehydrogenase And Pyruvate Dehydrogenase Kinase
  • Methods Of Evolving A Polynucleotides By Mutagenesis And Recombination
  • Methods For Modifying Human Antibodies By Glycan Engineering
  • Endoglin Antibodies
  • Method For Inhibiting The Immune Suppressive Function Of Human T Regulatory Cells By Administering An Anti-Garp Monoclonal Antibody
  • S. Pneumoniae Antigens
  • Transgenic Non-Human Animals Capable Of Producing Heterologous Antibodies
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Idiotypic Antibodies And Uses Thereof
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Liquid Protein Formulations Containing Thiamine
  • Method Of Predicting Animal Litter Size Using Protein Biomarkers Related With Fertility, And Method Of Predicting Animal Sperm Quality And Litter Size Using Chlortetracycline Staining
  • Identification Of Antigen Or Ligand-Specific Binding Proteins
  • Insulin Vitamin D Conjugates
  • Evolution Of Site-Specific Recombinases
  • Method For Selecting A Single Cell Expressing A Heterogeneous Combination Of Antibodies
  • Uses Of Wnt Polypeptides
  • Methods And Compositions For Polypeptide Engineering
  • Il-18 Binding Proteins
  • Methods Of Increasing Progranulin Levels Using Anti-Sortilin Antibodies
  • Antibody To Gdf8 And Uses Thereof
  • Antibody Selection Methods Using Cell Surface Expressed Libraries
  • Glypican-3-Specific Antibody And Uses Thereof
  • Chimeric Retroviral Gag Genes And Screening Assays
  • Methods For Administering Peptides For The Generation Of Effective C/S Conformation-Specific Antibodies To A Human Subject In Need Thereof
  • Combination Of A Pd-1 Antagonist And An Alk Inhibitor For Treating Cancer
  • Antibodies Specific For Native Prpsc
  • Antibodies To Tgf-Β
  • Antibody/T-Cell Receptor Chimeric Constructs And Uses Thereof
  • Antibodies Specific To Human T-Cell Immunoglobulin And Itim Domain (Tigit)
  • Anti-Siglec-15 Antibody
  • Rtk-Bpb Specifically Binding To Rtk
  • Colony Stimulating Bfcator Specific Monoclonal Antibody For Use In Diagnosis, Prevention And Treatment Of Infcetion, Cell Proliferative, Inflammatory, Autoimmune, Arthritic, Skin, Respiratory And Nervous System Disorders
  • Biomarker Composition Comprising Txndc7 For Diagnosis Or Predicting Prognosis Of Hepatocellular Carcinoma
  • Signal Biomarkers
  • “Immune Checkpoint Intervention” In Cancer
  • Methods Of Inhibiting Growth Of A Colon Cancer Tumor In A Subject By Administering Monoclonal Antibodies To G Protein-Coupled Receptor 49 (Gpr49)
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Antibody Producing Non-Human Mammals
  • Pdx1 Expressing Endoderm
  • Monoclonal Antibody That Binds Human Notch2 And Notch3
  • Pyrrolobenzodiazepine Conjugates And Their Use For The Treatment Of Cancer
  • Antibody Drug Conjugates (Adcs) And Antibody Prodrug Conjugates (Apdcs) With Enzymatically Cleavable Groups
  • Anti-Complement Factor H Antibodies
  • Decreasing Lactate Level And Increasing Polypeptide Production By Downregulating The Expression Of Lactate Dehydrogenase And Pyruvate Dehydrogenase Kinase
  • Interleukin-13 Binding Proteins
  • Neuritogenic Peptides
  • Engineered Cells For Adoptive Cell Therapy
  • Use Of Sirt7 As Novel Cancer Therapy Target And Method For Treating Cancer Using The Same
  • Beta-Catenin Inhibitors In Cancer Immunotherapy
  • Human Binding Molecules Having Killing Activity Against Staphylococci And Uses Thereof
  • Modified Hepatitis C Virus Proteins
  • Stable Igg4 Based Binding Agent Formulations
  • Method For Producing Polypeptide Heteromultimer
  • Listeria-Based Adjuvants
  • Methods And Compositions For Making Antibodies And Antibody Derivatives With Reduced Core Fucosylation
  • R9detection Of Preferential Polypeptide In Sample; Obtain Sample Of Polypeptide, Incubate With Bacteriophage, Monitor Adjustment In Activity, Adjustment In Activity
  • Methods For Viral Inactivation And Other Adventitious Agents
  • Cell-Permeable Probes For Identification And Imaging Of Sialidases
  • Genetically Modified Non-Human Mammals And Cells
  • Gitr Antibodies And Methods Of Inducing Or Enhancing An Immune Response
  • Covalently Linked Antigen-Antibody Conjugates
  • Internalizing Erbb2 Antibodies
  • Anti-Mpl Antibodies
  • Tetravalent Anti-Psgl-1 Antibodies And Uses Thereof
  • Isolation And Purification Of Anti-Il-13 Antibodies Using Protein A Affinity Chromatography
  • Antigen-Binding Molecule Containing Modified Fc Region
  • Antibody Constructs For Cdh19 And Cd3
  • A Collection Of Phagemids, A Collection Of Escherichia Coli Cells Carrying The Phagemids, A Collection Of Phagemid Particles Produced From Said Collection And Phagemid Particles Obtained According To The Process
  • Methods For Producing Members Of Specific Binding Pairs
  • Serum Albumin Binding Molecules
  • Method For The Detection Of A Binding Partner Of A Multispecific Binder
  • Notch Receptor (Dll-4) Specific Monclonal Antibody For Use In Diagnosis, Prevention And Treatment Of Cell Proliferative Disorders
  • Composition And Method For The Diagnosis And Treatment Of Iron-Related Disorders
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Uses
  • Surface Expression Libraries Of Heteromeric Receptors
  • Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Methods Of Using Anti-Lap Antibodies
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Pectate Lyase Signal Sequence
  • Monoclonal Antibodies To Growth And Differentiation Factor 15 (Gdf-15)
  • Methods And Compositions For Loading Of Polymerase Complexes
  • Charged Linkers And Their Uses For Conjugation
  • Ddr1-Binding Agents And Methods Of Use Thereof
  • Lrp-8 Binding Dual Variable Domain Immunoglobulin Proteins
  • Anti-Angiogenic Compounds
  • Synthetic Ligation Reassembly In Directed Evolution
  • Antibodies That Bind Il-18 And Methods Of Inhibiting Il-18 Activity
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Antibody/T-Cell Receptor Chimeric Constructs And Uses Thereof
  • Bace1 Antibodies
  • Modular Assembly Of Antibody Genes, Antibodies Prepared Thereby And Use
  • Methods Of Treating Cancer By Administering Igf-Ir Binding Molecules
  • Modified J-Chain
  • Methods And Compositions Comprising Purified Recombinant Polypeptides
  • Methods Of Modifying Antibodies For Purification Of Bispecific Antibodies
  • Stem Cell Factor Inhibitor
  • Modified Hepatitis C Virus Proteins
  • Methods And Compositions For Loading Of Polymerase Complexes
  • Charged Linkers And Their Uses For Conjugation
  • Ddr1-Binding Agents And Methods Of Use Thereof
  • Hepatocyte Lineage Cells
  • Methods Of Generating Libraries And Uses Thereof
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Listeria-Based Adjuvants
  • Methods And Compositions For Making Antibodies And Antibody Derivatives With Reduced Core Fucosylation
  • Use Of Sirt7 As Novel Cancer Therapy Target And Method For Treating Cancer Using The Same
  • Beta-Catenin Inhibitors In Cancer Immunotherapy
  • Human Binding Molecules Having Killing Activity Against Staphylococci And Uses Thereof
  • Method For Producing Polypeptide Heteromultimer
  • Engineered Cells For Adoptive Cell Therapy
  • Anti-Mpl Antibodies
  • Tetravalent Anti-Psgl-1 Antibodies And Uses Thereof
  • Isolation And Purification Of Anti-Il-13 Antibodies Using Protein A Affinity Chromatography
  • Antigen-Binding Molecule Containing Modified Fc Region
  • Antibody Constructs For Cdh19 And Cd3
  • Methods For Treating Or Preventing Asthma By Administering An Il-4r Antagonist
  • Antibodies To Prevent Tissue Rejection
  • Anti-Inflammatory Treatment Via Inhibition Of Endothelial Cell Kinesin Light Chain 1, Variant 1 (Klc1c)
  • Methods Of Reducing The Risk Of Experiencing A Cardiovascular (Cv) Event Or A Cerebrovascular Event In A Patient That Has Suffered A Qualifying Cv Event
  • Cc-Chemokine Binding Tick Proteins
  • Surface Expression Libraries Of Heteromeric Receptors
  • Humanized Anti-Cxcr5 Antibodies, Derivatives Thereof And Their Uses
  • Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Stable Igg4 Based Binding Agent Formulations
  • A Collection Of Phagemids, A Collection Of Escherichia Coli Cells Carrying The Phagemids, A Collection Of Phagemid Particles Produced From Said Collection And Phagemid Particles Obtained According To The Process
  • Methods For Producing Members Of Specific Binding Pairs
  • Serum Albumin Binding Molecules
  • Method For The Detection Of A Binding Partner Of A Multispecific Binder
  • Notch Receptor (Dll-4) Specific Monclonal Antibody For Use In Diagnosis, Prevention And Treatment Of Cell Proliferative Disorders
  • Composition And Method For The Diagnosis And Treatment Of Iron-Related Disorders
  • Dp04 Polymerase Variants
  • Methods And Means For The Production Of Ig-Like Molecules
  • Antibody/T-Cell Receptor Chimeric Constructs And Uses Thereof
  • Cytotoxic Agents For Conjugation To A Cell Binding Molecule
  • Method For Enzymatic Production Of Decarboxylated Polyketides And Fatty Acids
  • Targeted Therapeutics Based On Engineered Proteins That Bind Egfr
  • Methods For Purifying A Target Protein From One Or More Impurities In A Sample
  • Antibodies Specific For Native Prpsc
  • Wise Binding Agents And Epitopes
  • Methods For Identifying And Isolating Cells Expressing A Polypeptide
  • Antibodies To Tgf-Β
  • Polysaccharide And Nucleic Acid Formulations Containing Viscosity-Lowering Agents
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Anti-Human Igg1 Antibody
  • Synthetic Ligation Reassembly In Directed Evolution
  • Liquid Protein Formulations Containing 4-(3-Butyl-1-Imidazolio)-1-Butane Sulfonate (Bim)
  • Modulators
  • Evolution Of Talens
  • Modulation Of Breast Cancer Growth By Modulation Of Xbp1 Activity
  • Pdx1 Expressing Endoderm
  • Anti-Cd33 Antibodies And Methods Of Use Thereof
  • Stable Protein Conformational Isomers And Methods For Producing And Isolating Such Isomers Are Disclosed. Methods Of Using Such Isomers, And Products And Compositions Comprising Such Isomers Are Also Disclosed.
  • Monoclonal Antibodies To Growth And Differentiation Factor 15 (Gdf-15), And Uses Thereof For Treating Cancer Cachexia And Cancer
  • Methods Of Inducing Or Enhancing An Immune Response In A Subject By Administering Agonistic Gitr Binding Antibodies
  • Nfia In Glial Fate Determination, Glioma Therapy And Astrocytoma Treatment
  • Rnai Vitamin D Conjugates
  • Evolution Of Site-Specific Recombinases
  • Il-1 Binding Proteins
  • Expansion Of Definitive Endoderm Cells
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Dual Specific Binding Proteins Directed Against Il-1Β And/Or Il-17
  • Pyrrolobenzodiazepines
  • Anti-Fzd10 Monoclonal Antibodies And Methods For Their Use
  • Human M2e Peptide Immunogens
  • Human Alpha-Folate Receptor Chimeric Antigen Receptor
  • Using Sited Directed Mutation, Heteroduplex Formation And Plasmid Delivery Systems To Generate Preferental Cellular Phenotypes In Cells
  • Detection Methods Employing Hcv Core Lipid And Dna Binding Domain Monoclonal Antibodies
  • Humanized Antibodies Which Bind To Human April (“A Proliferation-Inducing Ligand”)
  • Useful For Identification, Tracking And Categorization Of Components Of Complex Mixtures Of Diverse Molecules; Drug Delivery
  • Bispecific Anti-Vegf/Anti-Ang-2 Antibodies And Their Use In The Treatment Of Ocular Vascular Diseases
  • Anti-Α2 Integrin Antibodies And Their Uses
  • Anti-Pd-L1 Antibodies And Methods Of Using The Same For Detection Of Pd-L1
  • High Affinity Tcr Proteins And Methods
  • The Biological Selection Of Useful Molecules
  • Anti-Biotin Antibodies And Methods Of Use
  • Antibodies For The Treatment Of Synucleinopathy
  • Complement Factor H Antibodies
  • Mutant Proteins And Methods For Producing Them
  • Anti-Vegf Antibodies
  • Single Molecule Nucleic Acid Nanoparticles
  • Antibody Recognizing Human Leukemia Inhibitory Factor (Lif) And Use Of Anti-Lif Antibodies In The Treatment Of Diseases Associated With Unwanted Cell Proliferation
  • Pyrrolobenzodiazepine-Anti-Cd22 Antibody Conjugates
  • Bispecific Anti-Human A-Beta/Human Transferrin Receptor Antibodies And Methods Of Use
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Zanamivir Phosphonate Congeners With Anti-Influenza Activity And Determining Oseltamivir Susceptibility Of Influenza Viruses
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Transgenic Animals Expressing Chimeric Antibodies For Use In Preparing Human Antibodies
  • Isolating Polypeptide From Solution; Incubation Of A Polypeptide In Solution With Compound Immobilized On Solid Support, Isolating Polypeptide From Solid Support
  • Compositions For Inhibiting Masp-2 Dependent Complement Activation
  • Liquid Protein Formulations Containing Thiamine Pyrophosphate (Tpp)
  • Neuropilin Antagonists
  • Benzocyclooctyne Compounds And Uses Thereof
  • Contacting A Polypeptide (Transmembrane Serin Protease 9) With A Substrate That Is Proteolytically Cleaved By The Polypeptide, Adding A Test Compound, Measuring The Amount Of Substrate Cleaved In The Presence Of Test Compound
  • Crystalline Anti-Human Il-12 Antibodies
  • Identification Of Antigen- Or Ligand-Specific Binding Proteins
  • Selection Of Binding-Molecules
  • Pyrrolobenzodiazepine-Anti-Psma Antibody Conjugates
  • Nucleic Acid Molecules Encoding Serine Protease Cvsp14, The Encoded Polypeptides And Methods Based Thereon
  • Phage Display
  • Chimeric Antigen Receptors Specific For B-Cell Maturation Antigen And Encoding Polynucleotides
  • Filamentous Bacteriophage Displaying An Β-Amyloid Epitope
  • Monoclonal Antibodies For The Treatment Of Viral Infections
  • Fibronectin Based Scaffold Proteins Having Improved Stability
  • Antibody Fc Variants
  • Methods Of Treating Psoriasis By Administration Of Antibodies To The P40 Subunit Of Il-12 And/Or Il-23
  • Anti-Mesothelin Immunoconjugates And Uses Therefor
  • Biosynthetic Binding Proteins For Immuno-Targeting
  • Antibody To Gdf8 And Uses Thereof
  • Antigen Binding Domains; Complementarity Determining Regions
  • Anti-Sortilin Antibodies And Methods Of Use Thereof
  • Single Molecule Nucleic Acid Nanoparticles
  • Antibody Recognizing Human Leukemia Inhibitory Factor (Lif) And Use Of Anti-Lif Antibodies In The Treatment Of Diseases Associated With Unwanted Cell Proliferation
  • Pyrrolobenzodiazepine-Anti-Cd22 Antibody Conjugates
  • Nucleic Acid Molecules Encoding A Transmembrane Serine Protease 10, The Encoded Polypeptides And Methods Based Thereon
  • Vectors And Genetically Engineered Immune Cells Expressing Metabolic Pathway Modulators And Uses In Adoptive Cell Therapy
  • Methods For Treating Pain By Administering A Nerve Growth Factor Antagonist And An Nsaid
  • Combination Therapies Comprising Anti-Erbb3 Agents
  • Bispecific Anti-Human A-Beta/Human Transferrin Receptor Antibodies And Methods Of Use
  • Humanized C3 Animals
  • Humanized Antibodies Which Bind To Human April (“A Proliferation-Inducing Ligand”)
  • Useful For Identification, Tracking And Categorization Of Components Of Complex Mixtures Of Diverse Molecules; Drug Delivery
  • Evolution Of Site-Specific Recombinases
  • Il-1 Binding Proteins
  • Expansion Of Definitive Endoderm Cells
  • Detection Methods Employing Hcv Core Lipid And Dna Binding Domain Monoclonal Antibodies
  • Human Alpha-Folate Receptor Chimeric Antigen Receptor
  • Pyrrolobenzodiazepines
  • Anti-Fzd10 Monoclonal Antibodies And Methods For Their Use
  • Bispecific Anti-Vegf/Anti-Ang-2 Antibodies And Their Use In The Treatment Of Ocular Vascular Diseases
  • Anti-Α2 Integrin Antibodies And Their Uses
  • Anti-Pd-L1 Antibodies And Methods Of Using The Same For Detection Of Pd-L1
  • High Affinity Tcr Proteins And Methods
  • Endoglin Antibodies
  • Antibodies Specific For Hyperphosphorylated Tau And Methods Of Use
  • Il-1 Binding Proteins
  • Methods For Identifying Inhibitors Of Vascular Injury
  • Dual Variable Domain Immunoglobulin And Uses Thereof
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Dual Specific Binding Proteins Directed Against Il-1Β And/Or Il-17
  • Using Sited Directed Mutation, Heteroduplex Formation And Plasmid Delivery Systems To Generate Preferental Cellular Phenotypes In Cells
  • Antibodies; Immunohistochemistry; Rna Interference; Gene Expression Inhibition
  • Polymerase Enzyme Substrates With Protein Shield
  • Human M2e Peptide Immunogens
  • Il-1 Binding Proteins
  • Method Of Generating Multiple Protein Variants And Populations Of Protein Variants Prepared Thereby
  • Cdr-Modified Anti-Siglec-15 Antibody
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Covalently Linked Polypeptide Toxin-Antibody Conjugates
  • Anti-Alpha2 Integrin Antibodies And Their Uses
  • Recombinase Mutants
  • Calpain Modulators And Therapeutic Uses Thereof
  • Recombinase Mutants
  • Gdf-15 As A Diagnostic Marker To Predict The Clinical Outcome Of A Treatment With Immune Checkpoint Blockers
  • Antibodies For The Treatment Of Synucleinopathy
  • Antibodies Against Kidney Associated Antigen 1 And Antigen Binding Fragments Thereof
  • Anti-Fzd10 Monoclonal Antibodies And Methods For Their Use
  • Akap84 And Its Use For Visualization Of Biological Structures
  • Histone Deacetylases, And Uses Related Thereto
  • Antibodies That Bind The Glutamate Ligand Binding Region Of Notch3
  • Constrained Immunogenic Compositions And Uses Therefor
  • Compositions And Methods For Treatment And Detection Of Cancers
  • Methods For Treating Inflammatory Bowel Disease
  • Anti-Vegf Antibodies
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Zanamivir Phosphonate Congeners With Anti-Influenza Activity And Determining Oseltamivir Susceptibility Of Influenza Viruses
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • Human Follicle-Stimulating Hormone Receptor (Fshr) Extracellular Domain Antibodies And Methods Of Use Thereof
  • Directed Evolution Of Novel Binding Proteins
  • Human Inkt Cell Activation Using Glycolipids
  • Immunoglobulins; Lymphokines; Hybridomas
  • Polypeptides Comprising Antigen Binding Domains For Diagnosis, Prevention And Treatment Of Inflammation, Skin, Respiratory, Kidney, Cardiovascular, Nervous System And Pancreatic Disorder
  • Evolution Of New Metabolic Pathways And The Enhancement Of Bioprocessing Through Recursive Sequence Recombination Which Entails Performing Interative Cycles Of Recombination And Screening To Evolve Indivisual Genes, Whole Plasmids, Viruses
  • Anti-Rankl Antibodies And Methods Of Use
  • Enhanced Protein Purification Through A Modified Protein A Elution
  • Method Of Treating Asthma Using An Il-13 Antibody
  • Deacetylase Inhibitors And Uses Thereof
  • Compositions And Methods For Detecting And Quantifying Host Cell Protein In Cell Lines And Recombinant Polypeptide Products
  • Detection Methods Employing Hcv Core Lipid And Dna Binding Domain Monoclonal Antibodies
  • Antibody Fragments Against The Insulin Receptor And Uses Thereof To Treat Hypoglycemia
  • Production Of Anti-Self Antibodies From Antibody Segment Repertories And Displayed On Phage
  • Methods Of Treating Kawasaki Disease Using Il-1beta Antibodies
  • Method For Producing And Obtaining Variable Domains Of Anti-Digoxin Monoclonal Antibody Fab Fragment Using The Molecular Biology Cloning Technique
  • Kid31 And Antibodies That Bind Thereto
  • Pyrrolobenzodiazepines And Conjugates Thereof
  • Method For Treating Joint Damage
  • Bispecific Antibodies
  • Reactive Labelling Compounds And Uses Thereof
  • Abeta Conformer Selective Anti-Abeta Globulomer Monoclonal Antibodies
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Agents And Method For Identifying Insects
  • Vegf/Dll4 Binding Agents And Uses Thereof
  • Il-I Binding Proteins
  • Multivalent Fibronectin Based Scaffold Domain Proteins
  • Treatment For Inflammatory Bowel Disease With A Vcam-1/1gg Fusion Protein
  • Antibody To Gdf8 And Uses Thereof
  • Biosynthetic Binding Proteins For Immuno-Targeting
  • Antibody Fc Variants
  • Methods Of Treating Psoriasis By Administration Of Antibodies To The P40 Subunit Of Il-12 And/Or Il-23
  • Use Of Anti-Cd83 Agonist Antibodies For Treating Autoimmune Diseases
  • Therapeutic Vitamin D Conjugates
  • Monoclonal Antibodies To Growth And Differentiation Factor 15 (Gdf-15)
  • Humanized Antibodies Against Ceacam1
  • Isolation And Identification Of Antigen- Or Ligand-Specific Binding Proteins
  • Filamentous Bacteriophage Displaying An Β-Amyloid Epitope
  • Selection Of Binding-Molecules
  • Anti-Mesothelin Immunoconjugates And Uses Therefor
  • Anti-Sortilin Antibodies And Methods Of Use Thereof
  • Vector-Based Mutagenesis System
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Cd3 Binding Polypeptides
  • Neuropilin Antagonists
  • Contacting A Polypeptide (Transmembrane Serin Protease 9) With A Substrate That Is Proteolytically Cleaved By The Polypeptide, Adding A Test Compound, Measuring The Amount Of Substrate Cleaved In The Presence Of Test Compound
  • Erbb3 Binding Antibody
  • Monoclonal Anti-Alpha-Synuclein Antibodies For Preventing Tau Aggregation
  • Cell Engaging Binding Molecules
  • Monoclonal Antibodies For The Treatment Of Viral Infections
  • Isolating Polypeptide From Solution; Incubation Of A Polypeptide In Solution With Compound Immobilized On Solid Support, Isolating Polypeptide From Solid Support
  • Transgenic Animals Expressing Chimeric Antibodies For Use In Preparing Human Antibodies
  • Fibronectin Based Scaffold Proteins Having Improved Stability
  • Pyrrolobenzodiazepine-Anti-Psma Antibody Conjugates
  • Nucleic Acid Molecules Encoding Serine Protease Cvsp14, The Encoded Polypeptides And Methods Based Thereon
  • Phage Display
  • Chimeric Antigen Receptors Specific For B-Cell Maturation Antigen And Encoding Polynucleotides
  • Antibodies To Tgf-Β
  • Selection Of Sequences With Desirable Binding Properties
  • Methods For Treating Post-Surgical Pain By Administering An Anti-Nerve Growth Factor Antagonist Antibody
  • Supramolecular High Affinity Protein-Binding System For Purification Of Biomacromolecules
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Antigen Binding Domains; Complementarity Determining Regions
  • Glycan Conjugates And Use Thereof
  • High Affinity Antibodies Against Hmgb1 And Methods Of Use Thereof
  • Liquid Protein Formulations Containing Thiamine Pyrophosphate (Tpp)
  • Crystalline Anti-Human Il-12 Antibodies
  • Benzocyclooctyne Compounds And Uses Thereof
  • Compositions For Inhibiting Masp-2 Dependent Complement Activation
  • Process For Preparing Antibody-Drug Conjugates With Improved Homogeneity
  • Identification Of Antigen- Or Ligand-Specific Binding Proteins
  • Human Cytomegalovirus Neutralizing Antibodies And Use Thereof
  • Co-Use Of A Clusterin Inhibitor With An Egfr Inhibitor To Treat Cancer
  • Humanized Anti-Tau(Ps422) Antibodies And Methods Of Use
  • Method Of Treatment Comprising Purified Recombinant Il-13 Antibody
  • Anti-Her2 Glycoantibodies And Uses Thereof
  • Anti-Trem2 Antibodies And Methods Of Use Thereof
  • Antibodies Specific For Native Prpsc
  • Comprises Expression Vectors Coding Accumulation And Replication Of Chloroplast (Arc) Polypeptides For Altering Size, Morphhology And Number Of Plastids In Crop Plants
  • Methods And Biomarkers For Predicting Efficacy And Evaluation Of An Ox40 Agonist Treatment
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Automatic Injection Device
  • Anti-Krs Monoclonal Antibody And Use Thereof
  • Anti-Il1rap Antibodies And Methods Of Use Thereof
  • Aβ Conformer Selective Anti-Aβ Globulomer Monoclonal Antibodies
  • Production Of Anti-Self Antibodies From Antibody Segment Repertoires And Displayed On Phage
  • Protease Screening Methods And Proteases Identified Thereby
  • Polypeptide Fusion Comprising Complementary Determining Regions For Use As Tool In Immunotherapeutic And/Or Diagnostics; Bioassay
  • Immunoglobulin Which Bind To Endothelial Growth Factor For Therapy Of Cell Proliferation; Antitumor Agents
  • Stabilizer For Protein Preparation Comprising Meglumine And Use Thereof
  • Binding Domain-Immunoglobulin Fusion Proteins
  • High Concentration Protein Formulations With Reduced Viscosity
  • Antibody Targeting Osteoclast-Related Protein Siglec-15
  • Human Monoclonal Antibodies To The Thyrotropin Receptor Which Act As Antagonists
  • Anti-Fgfr3 Antibodies And Methods Using Same
  • Identification And Cloning Of A Novel Neutralizing Human Monoclonal Antibody To The Respiratory Syncytial Virus. The Invention Provides Such Antibodies, Fragments Of Such Antibodies Retaining Rsv-Binding Ability, Chimeric Antibodies
  • Composition And Method For The Diagnosis And Treatment Of Iron-Related Disorders
  • Anti-Pdgf-C Antibodies
  • Dosage Regimes For The Administration Of An Anti-Cd25 Adc
  • Combination Of Epigenetic Factors And Bispecific Compounds Targeting Cd33 And Cd3 In The Treatment Of Myeloid Leukemia
  • Synthetic Ligation Reassembly In Directed Evolution
  • Cd37 Immunotherapeutics And Uses Thereof
  • Antibodies To Insulin-Like Growth Factor I Receptor
  • Methods Of Treating Gout Using Il-1beta Antibodies
  • Monomeric And Dimeric Forms Of Adiponectin Receptor Fragments And Methods Of Use
  • Acetylenedicarboxyl Linkers And Their Uses In Specific Conjugation Of A Cell-Binding Molecule
  • Binding To Monoclonal Antibody; Antitumor Agents
  • Antibodies That Bind To Tl1a And Their Uses
  • Elucidation Of Ion Exchange Chromatography Input Optimization
  • Liquid Pharmaceutical Formulations For Injection Comprising Yellow 5 Or Orange G And Uses Thereof
  • Methods And Compositions For Regulating Lymphocyte Activity
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Genus-Wide Chlamydial Peptide Vaccine Antigens
  • Autoantibody Enhanced Immunoassays And Kits
  • Activator Of G Protein Signaling, Or ?Ags?; Recombinant Expression Vectors Containing A Nucleic Acid Molecule Of The Protein/Nucleic Acid
  • Immunoglobulin For Detecting Inflammation And Bacterial Infections In Mammals
  • Binding Domains Of Proteins Of The Repulsive Guidance Molecule (Rgm) Protein Family And Functional Fragments Thereof, And Their Use
  • Magneto-Motive Ultrasound Detection Of Magnetic Nanoparticles
  • Anti-Siglec-7 Antibodies And Methods Of Use Thereof
  • Pyrrolobenzodiazepine-Antibody Conjugates
  • The Biological Selection Of Useful Molecules
  • Dual Delivery System For Heterologous Antigens
  • Anti-Vegf Antibodies
  • Prostaglandin E2 Dual Variable Domain Immunoglobulins And Uses Thereof
  • Antibodies For The Treatment Of Synucleinopathy
  • Complement Factor H Antibodies
  • Mutant Proteins And Methods For Producing Them
  • Anti-Vegf Antibodies
  • Anti-Biotin Antibodies And Methods Of Use
  • Pyrrolobenzodiazepine—Anti-Psma Antibody Conjugates
  • Methods For Treating Bone Cancer By Administering A Nerve Growth Factor Antagonist Antibody
  • Detection Methods Employing Hcv Core Lipid And Dna Binding Domain Monoclonal Antibodies
  • Nucleic Acid Molecules Encoding A Humanized Antibody
  • Methods And Reagents For Isolating Biologically Active Peptides
  • Hcv Core Lipid Binding Domain Monoclonal Antibodies
  • Agents, Uses And Methods For The Treatment Of Synucleinopathy
  • Methods Of Treating Hedgehog-Related Diseases With An Anti-Lgr5 Antibody
  • Stirred Tank Bioreactor
  • Continuous Directed Evolution
  • Vector-Based Mutagenesis System
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Cd3 Binding Polypeptides
  • Specific Antibody-Drug-Conjugates (Adcs) With Ksp Inhibitors And Anti-Cd123-Antibodies
  • Therapeutic Dll4 Binding Proteins
  • Binding Domain-Immunoglobulin Fusion Proteins
  • Reactive Labelling Compounds And Uses Thereof
  • Abeta Conformer Selective Anti-Abeta Globulomer Monoclonal Antibodies
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Co-Use Of A Clusterin Inhibitor With An Egfr Inhibitor To Treat Cancer
  • Methods For Diagnosing And Treating Inflammatory Bowel Disease
  • Phagemids And Process Of Preparation
  • Identifying Sclerostin Antagonist Via Abilty To Prevent Apoptosis; Treating Osteoporosis
  • Dual Specific Binding Proteins Directed Against Il-13 And Il-17
  • The Isolation And Production Of Catalytic Antibodies Using Phage Technology
  • Antibodies Against Lif And Uses Thereof
  • Fast-Off Rate Serum Albumin Binding Fibronectin Type Iii Domains
  • Multivalent Fibronectin Based Scaffold Domain Proteins
  • Humanized Anti-Tau(Ps422) Antibodies And Methods Of Use
  • Continuous Directed Evolution
  • Methods Of Producing Two Chain Proteins In Bacteria
  • Antibodies That Bind To Mhc Class I Polypeptide-Related Sequence A
  • Preventing Cd28 Binding To B7 By Monovalent Fragments Antibody Called Cd28.3 Of Which Exhibit Sufficient Affinity For The Antigen So That They Can Be Used, In Vitro Or In Vivo, To Block The Cd28 Receptor Without Activation Of This Receptor; Autoimmune Diseases; Transplant Rejection
  • Antibodies Against Il-18r1 And Uses Thereof
  • Modified Factor Vii Polypeptides And Uses Thereof
  • Humanized Antibodies That Bind Lgr5
  • Transforming Microorganism And Monitoring Expression Of Heterologous Proteins On Cell Surface; Monitoring Protein-Protein Interactions And Identifying Modulators For Treating Autoimmune And Cell Proliferative Diseases
  • For Therapy Of Condition In A Subject Characterized By Activation Of An Inflammatory Cytokine Cascade
  • Fc Variants And Methods For Their Production
  • Antigen Binding Complex Having Agonistic Activity And Methods Of Use
  • Il-17 Binding Proteins
  • Methods And Compositions For Delivery Of Molecules And Complexes To Reaction Sites
  • Methods And Compositions For Cellular And Metabolic Engineering
  • Siglec 15 Antibodies In Treating Bone Loss-Related Disease
  • Antibodies Specific For Native Prpsc
  • Polypeptides Capable Of Forming Antigen Binding Structures With Specificity For The Rhesus D Antigens, The Dna Encoding Them And The Process For Their Preparation And Use
  • Immunoglobulin Peptides Against Heated Bovine Blood
  • Use Of Anti-Cd83 Agonist Antibodies For Treating Autoimmune Diseases
  • Therapeutic Vitamin D Conjugates
  • Monoclonal Antibodies To Growth And Differentiation Factor 15 (Gdf-15)
  • Humanized Antibodies Against Ceacam1
  • Agents And Method For Identifying Insects
  • Cxc-Chemokine Antagonists Isolated From Rhipicephalus Sanguineus
  • Pharmacokinetic Modulation And Compositions For Modified Fn3 Polypeptides
  • Anti-Cd33 Antibodies And Methods Of Use Thereof
  • Acetylenedicarboxyl Linkers And Their Uses In Specific Conjugation Of A Cell-Binding Molecule
  • Chagasin-Based Scaffold Compositions, Methods, And Uses
  • Antibodies Recognizing A Carbohydrate Containing Epitope On Cd-43 And Cea Expressed On Cancer Cells And Methods Using Same
  • Cytotoxicity-Inducing Theraputic Agent
  • Definitive Endoderm
  • Nucleic Acid-Polypeptide Compositions And Uses Thereof
  • Antibodies Against N-Acetylglucosamine And N-Acetyl-Galactosamine
  • Biomarker Composition Comprising Nox4 For Diagnosis Or Predicting Prognosis Of Hepatocellular Carcinoma
  • Multimeric Bispecific Binding Molecules Specific For Cd20 And Cd3
  • Method For In Vitro Molecular Evolution Of Protein Function
  • Nucleic Acids Coding For Antibodies Against Human Il-21 Receptor And Uses Therefor
  • Dual Variable Domain Immunoglobulins And Uses Thereof
  • Taurine Supplemented Cell Culture Medium And Methods Of Use
  • Insulin Vitamin D Conjugates
  • Compositions And Methods For Treatment And Detection Of Cancers
  • Specific Conjugation Linkers, Specific Immunoconjugates Thereof, Methods Of Making And Uses Such Conjugates Thereof
  • Recombinant Production Of Mixtures Of Antibodies
  • Method For Treating Gram Positive Septicemia
  • Pyrrolobenzodiazepine-Anti-Cd22 Antibody Conjugates
  • Anti-Ige Antibodies
  • Comprising A Variant Heavy Chain Variable Framework Domain And Complementary Determining Regions; Useful For Identifying Novel Polypeptides, Antibody, Antibody Fragments, And Antibody Variable Domains That May Be Used Therapeutically Or As Reagents
  • Charged Linkers And Their Uses For Conjugation
  • Production Of Proteins In Glutamine-Free Cell Culture Media
  • Pichia Pastoris Formate Dehydrogenase And Uses Therefor
  • Human Antibodies That Bind Human Madcam
  • Methods For Inducing An Immune Response By Inhibition Of Nonsense Mediated Decay
  • Methods For Generating Polynucleotides Having Desired Characteristics By Iterative Selection And Recombination
  • Therapeutic Dll4 Binding Proteins
  • Anti-Il-12/Il-23 Antibodies
  • Gpcr-Bpb Specifically Binding To Gpcr
  • Antibodies To M-Csf
  • Anti-Vegf Antibodies
  • Generation Of Modified Polymerases For Improved Accuracy In Single Molecule Sequencing
  • Human Cytomegalovirus Neutralising Antibodies And Use Thereof
  • Antibodies Against Lif And Uses Thereof
  • Rationally Designed, Synthetic Antibody Libraries And Uses Therefor
  • Multimeric Bispecific Binding Molecules Specific For Cd20 And Cd3
  • Specific Conjugation Linkers, Specific Immunoconjugates Thereof, Methods Of Making And Uses Such Conjugates Thereof
  • Recombinant Production Of Mixtures Of Antibodies
  • Anti-Vegf Antibodies
  • Acetylenedicarboxyl Linkers And Their Uses In Specific Conjugation Of A Cell-Binding Molecule
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/352624a0

    DOI

    http://dx.doi.org/10.1038/352624a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021945431

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1907718


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