Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-08

AUTHORS

Hubert Schorle, Thomas Holtschke, Thomas Hünig, Anneliese Schimpl, Ivan Horak

ABSTRACT

INTERLEUKIN-2 (IL-2) is a lymphocytotropic hormone which is thought to have a key role in the immune response of mammalian cells. It is produced by a subpopulation of activated T-lymphocytes and acts in vitro as the principal auto- and paracrine T-cell growth factor (for reviews see refs 1–3). IL-2 is, however, not the sole T-cell growth factor4,5, nor does it act exclusively on T cells, also promoting growth of NK cells6 and differentiation of B cells7. A role for IL-2 in T-cell development has been postulated but remains controversial8–12. Here we test the requirement for IL-2 in vivo using IL-2-deficient mice generated by targeted recombination. We find that mice homozygous for the IL-2 gene mutation are normal with regard to thymocyte and peripheral T-cell subset composition, but that a dysregulation of the immune system is manifested by reduced polyclonal in vitro T-cell responses and by dramatic changes in the isotype levels of serum immunoglobulins. More... »

PAGES

621-624

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/352621a0

DOI

http://dx.doi.org/10.1038/352621a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015644987

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1830926


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Formation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Differentiation, T-Lymphocyte", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Isotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocyte Subsets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes, Helper-Inducer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymus Gland", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schorle", 
        "givenName": "Hubert", 
        "id": "sg:person.0702743763.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702743763.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holtschke", 
        "givenName": "Thomas", 
        "id": "sg:person.01224470666.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224470666.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00fcnig", 
        "givenName": "Thomas", 
        "id": "sg:person.01273373020.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273373020.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schimpl", 
        "givenName": "Anneliese", 
        "id": "sg:person.0615546657.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615546657.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.8379.5", 
          "name": [
            "Institute of Virology and Immunobiology, University of W\u00fcrzburg, Versbacherstrasse 7, 8700, W\u00fcrzburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horak", 
        "givenName": "Ivan", 
        "id": "sg:person.01076431677.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076431677.67"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/292154a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017487986", 
          "https://doi.org/10.1038/292154a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/342435a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038924064", 
          "https://doi.org/10.1038/342435a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-83755-5_82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045568161", 
          "https://doi.org/10.1007/978-3-642-83755-5_82"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/330576a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004645846", 
          "https://doi.org/10.1038/330576a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329160a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034231744", 
          "https://doi.org/10.1038/329160a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/326292a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050105118", 
          "https://doi.org/10.1038/326292a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/336684a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038677733", 
          "https://doi.org/10.1038/336684a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1991-08", 
    "datePublishedReg": "1991-08-01", 
    "description": "INTERLEUKIN-2 (IL-2) is a lymphocytotropic hormone which is thought to have a key role in the immune response of mammalian cells. It is produced by a subpopulation of activated T-lymphocytes and acts in vitro as the principal auto- and paracrine T-cell growth factor (for reviews see refs 1\u20133). IL-2 is, however, not the sole T-cell growth factor4,5, nor does it act exclusively on T cells, also promoting growth of NK cells6 and differentiation of B cells7. A role for IL-2 in T-cell development has been postulated but remains controversial8\u201312. Here we test the requirement for IL-2 in vivo using IL-2-deficient mice generated by targeted recombination. We find that mice homozygous for the IL-2 gene mutation are normal with regard to thymocyte and peripheral T-cell subset composition, but that a dysregulation of the immune system is manifested by reduced polyclonal in vitro T-cell responses and by dramatic changes in the isotype levels of serum immunoglobulins.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/352621a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6336", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "352"
      }
    ], 
    "keywords": [
      "cell subset composition", 
      "cell growth factor", 
      "IL-2-deficient mice", 
      "subset composition", 
      "isotype levels", 
      "serum immunoglobulins", 
      "immune response", 
      "cell responses", 
      "interleukin-2", 
      "immune system", 
      "growth factor", 
      "gene mutations", 
      "mice", 
      "cell development", 
      "cell growth", 
      "cells", 
      "lymphocytes", 
      "response", 
      "immunoglobulin", 
      "hormone", 
      "gene targeting", 
      "thymocytes", 
      "key role", 
      "dysregulation", 
      "subpopulations", 
      "role", 
      "vivo", 
      "targeted recombination", 
      "cells7", 
      "targeting", 
      "mutations", 
      "differentiation", 
      "factors", 
      "development", 
      "levels", 
      "mammalian cells", 
      "regard", 
      "changes", 
      "growth", 
      "dramatic changes", 
      "function", 
      "auto", 
      "system", 
      "requirements", 
      "composition", 
      "recombination", 
      "lymphocytotropic hormone", 
      "principal auto", 
      "NK cells6", 
      "cells6", 
      "controversial8", 
      "IL-2 gene mutation"
    ], 
    "name": "Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting", 
    "pagination": "621-624", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015644987"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/352621a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1830926"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/352621a0", 
      "https://app.dimensions.ai/details/publication/pub.1015644987"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T17:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_244.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/352621a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/352621a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/352621a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/352621a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/352621a0'


 

This table displays all metadata directly associated to this object as RDF triples.

234 TRIPLES      22 PREDICATES      102 URIs      87 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/352621a0 schema:about N1162ca8beda448c4af08c5ed2a1a05b8
2 N49d65ca11aa44d87ab17ef98a452d355
3 N5b3be869d184442e8184c2ec1bbb9c08
4 N5c634dc9849748989d14f815e1c086d8
5 N6f580102387d464a915fa5076b4b2aaa
6 N7c69cc03f2884812a6c4d6a0fe2a8b66
7 N805c946792464b34abce14be6615109d
8 N8163befec5e14735af92da54a4da4cff
9 N85fab0d33e654ffbb5f3a6929bb5408c
10 N968ade36c1734bc2b3d3cfe329caf81d
11 Nad2a7cdeda3c4089966aa25ec68b0cf0
12 Nb043544768e440588781e9e0215a8419
13 Nc96b743da9524064a2b0060c8ff1561c
14 Nc9b8f1e680a3473ca62accfcac4e9173
15 Nda1b2057f0044d1d96cdecc2e5a9b60a
16 Ndb131c06fe9949fdb54cfd42243920ea
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author N92edf6d62d89479195f3b8567144979a
20 schema:citation sg:pub.10.1007/978-3-642-83755-5_82
21 sg:pub.10.1038/292154a0
22 sg:pub.10.1038/326292a0
23 sg:pub.10.1038/329160a0
24 sg:pub.10.1038/330576a0
25 sg:pub.10.1038/336684a0
26 sg:pub.10.1038/342435a0
27 schema:datePublished 1991-08
28 schema:datePublishedReg 1991-08-01
29 schema:description INTERLEUKIN-2 (IL-2) is a lymphocytotropic hormone which is thought to have a key role in the immune response of mammalian cells. It is produced by a subpopulation of activated T-lymphocytes and acts in vitro as the principal auto- and paracrine T-cell growth factor (for reviews see refs 1–3). IL-2 is, however, not the sole T-cell growth factor4,5, nor does it act exclusively on T cells, also promoting growth of NK cells6 and differentiation of B cells7. A role for IL-2 in T-cell development has been postulated but remains controversial8–12. Here we test the requirement for IL-2 in vivo using IL-2-deficient mice generated by targeted recombination. We find that mice homozygous for the IL-2 gene mutation are normal with regard to thymocyte and peripheral T-cell subset composition, but that a dysregulation of the immune system is manifested by reduced polyclonal in vitro T-cell responses and by dramatic changes in the isotype levels of serum immunoglobulins.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree false
33 schema:isPartOf N2102878db9344164bce74f449aa8dfe8
34 N87bcd0c7bcfa4ae78947e2b55f62c86c
35 sg:journal.1018957
36 schema:keywords IL-2 gene mutation
37 IL-2-deficient mice
38 NK cells6
39 auto
40 cell development
41 cell growth
42 cell growth factor
43 cell responses
44 cell subset composition
45 cells
46 cells6
47 cells7
48 changes
49 composition
50 controversial8
51 development
52 differentiation
53 dramatic changes
54 dysregulation
55 factors
56 function
57 gene mutations
58 gene targeting
59 growth
60 growth factor
61 hormone
62 immune response
63 immune system
64 immunoglobulin
65 interleukin-2
66 isotype levels
67 key role
68 levels
69 lymphocytes
70 lymphocytotropic hormone
71 mammalian cells
72 mice
73 mutations
74 principal auto
75 recombination
76 regard
77 requirements
78 response
79 role
80 serum immunoglobulins
81 subpopulations
82 subset composition
83 system
84 targeted recombination
85 targeting
86 thymocytes
87 vivo
88 schema:name Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
89 schema:pagination 621-624
90 schema:productId N862a931228094efe9c366dc97801ca91
91 N8a0119e4e6cd4153b1d01632b00c626e
92 Nb2a30fea6dde489c907e3c8b8130a956
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015644987
94 https://doi.org/10.1038/352621a0
95 schema:sdDatePublished 2021-11-01T17:59
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher Nc8d9bcae5b3c4c70b7f61213ac0d0a06
98 schema:url https://doi.org/10.1038/352621a0
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N1162ca8beda448c4af08c5ed2a1a05b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Immunoglobulin Isotypes
104 rdf:type schema:DefinedTerm
105 N1a98baaf3e0e4e338519a9993806c09e rdf:first sg:person.0615546657.73
106 rdf:rest Nccbf48155c494eee90c9fad77775a976
107 N2102878db9344164bce74f449aa8dfe8 schema:volumeNumber 352
108 rdf:type schema:PublicationVolume
109 N49d65ca11aa44d87ab17ef98a452d355 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Lymph Nodes
111 rdf:type schema:DefinedTerm
112 N5b3be869d184442e8184c2ec1bbb9c08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name CD4 Antigens
114 rdf:type schema:DefinedTerm
115 N5c634dc9849748989d14f815e1c086d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name CD8 Antigens
117 rdf:type schema:DefinedTerm
118 N6f580102387d464a915fa5076b4b2aaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Antibody Formation
120 rdf:type schema:DefinedTerm
121 N7c69cc03f2884812a6c4d6a0fe2a8b66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name T-Lymphocytes
123 rdf:type schema:DefinedTerm
124 N7f59f86dfdd3475fa6c569856c6048e0 rdf:first sg:person.01224470666.03
125 rdf:rest Nd150182842f04defa8ac4e3793078c26
126 N805c946792464b34abce14be6615109d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name DNA Mutational Analysis
128 rdf:type schema:DefinedTerm
129 N8163befec5e14735af92da54a4da4cff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name T-Lymphocyte Subsets
131 rdf:type schema:DefinedTerm
132 N85fab0d33e654ffbb5f3a6929bb5408c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Lymphocyte Activation
134 rdf:type schema:DefinedTerm
135 N862a931228094efe9c366dc97801ca91 schema:name doi
136 schema:value 10.1038/352621a0
137 rdf:type schema:PropertyValue
138 N87bcd0c7bcfa4ae78947e2b55f62c86c schema:issueNumber 6336
139 rdf:type schema:PublicationIssue
140 N8a0119e4e6cd4153b1d01632b00c626e schema:name dimensions_id
141 schema:value pub.1015644987
142 rdf:type schema:PropertyValue
143 N92edf6d62d89479195f3b8567144979a rdf:first sg:person.0702743763.66
144 rdf:rest N7f59f86dfdd3475fa6c569856c6048e0
145 N968ade36c1734bc2b3d3cfe329caf81d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name T-Lymphocytes, Helper-Inducer
147 rdf:type schema:DefinedTerm
148 Nad2a7cdeda3c4089966aa25ec68b0cf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Mice
150 rdf:type schema:DefinedTerm
151 Nb043544768e440588781e9e0215a8419 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Interleukin-2
153 rdf:type schema:DefinedTerm
154 Nb2a30fea6dde489c907e3c8b8130a956 schema:name pubmed_id
155 schema:value 1830926
156 rdf:type schema:PropertyValue
157 Nc8d9bcae5b3c4c70b7f61213ac0d0a06 schema:name Springer Nature - SN SciGraph project
158 rdf:type schema:Organization
159 Nc96b743da9524064a2b0060c8ff1561c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Cell Differentiation
161 rdf:type schema:DefinedTerm
162 Nc9b8f1e680a3473ca62accfcac4e9173 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Thymus Gland
164 rdf:type schema:DefinedTerm
165 Nccbf48155c494eee90c9fad77775a976 rdf:first sg:person.01076431677.67
166 rdf:rest rdf:nil
167 Nd150182842f04defa8ac4e3793078c26 rdf:first sg:person.01273373020.49
168 rdf:rest N1a98baaf3e0e4e338519a9993806c09e
169 Nda1b2057f0044d1d96cdecc2e5a9b60a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Antigens, Differentiation, T-Lymphocyte
171 rdf:type schema:DefinedTerm
172 Ndb131c06fe9949fdb54cfd42243920ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Animals
174 rdf:type schema:DefinedTerm
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
179 schema:name Immunology
180 rdf:type schema:DefinedTerm
181 sg:journal.1018957 schema:issn 0028-0836
182 1476-4687
183 schema:name Nature
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.01076431677.67 schema:affiliation grid-institutes:grid.8379.5
187 schema:familyName Horak
188 schema:givenName Ivan
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076431677.67
190 rdf:type schema:Person
191 sg:person.01224470666.03 schema:affiliation grid-institutes:grid.8379.5
192 schema:familyName Holtschke
193 schema:givenName Thomas
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224470666.03
195 rdf:type schema:Person
196 sg:person.01273373020.49 schema:affiliation grid-institutes:grid.8379.5
197 schema:familyName Hünig
198 schema:givenName Thomas
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273373020.49
200 rdf:type schema:Person
201 sg:person.0615546657.73 schema:affiliation grid-institutes:grid.8379.5
202 schema:familyName Schimpl
203 schema:givenName Anneliese
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615546657.73
205 rdf:type schema:Person
206 sg:person.0702743763.66 schema:affiliation grid-institutes:grid.8379.5
207 schema:familyName Schorle
208 schema:givenName Hubert
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702743763.66
210 rdf:type schema:Person
211 sg:pub.10.1007/978-3-642-83755-5_82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045568161
212 https://doi.org/10.1007/978-3-642-83755-5_82
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/292154a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017487986
215 https://doi.org/10.1038/292154a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/326292a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050105118
218 https://doi.org/10.1038/326292a0
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/329160a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034231744
221 https://doi.org/10.1038/329160a0
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/330576a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004645846
224 https://doi.org/10.1038/330576a0
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/336684a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038677733
227 https://doi.org/10.1038/336684a0
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/342435a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038924064
230 https://doi.org/10.1038/342435a0
231 rdf:type schema:CreativeWork
232 grid-institutes:grid.8379.5 schema:alternateName Institute of Virology and Immunobiology, University of Würzburg, Versbacherstrasse 7, 8700, Würzburg, Germany
233 schema:name Institute of Virology and Immunobiology, University of Würzburg, Versbacherstrasse 7, 8700, Würzburg, Germany
234 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...