Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-06

AUTHORS

D S Bredt, P M Hwang, C E Glatt, C Lowenstein, R R Reed, S H Snyder

ABSTRACT

Nitric oxide is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors. The only known mammalian enzyme with close homology is cytochrome P-450 reductase. More... »

PAGES

714-718

Journal

TITLE

Nature

ISSUE

6329

VOLUME

351

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/351714a0

    DOI

    http://dx.doi.org/10.1038/351714a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008241995

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1712077


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