Membrane protein association by potential intrarnembrane charge pairs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-05

AUTHORS

Pierre Cosson, Scott P. Lankford, Juan S. Bonifacino, Richard D. Klausner

ABSTRACT

THE transmembrane domain of the α chain of the T-cell receptor is responsible both for its assembly with the CD3 δ chain1 and for rapid degradation of the unassembled chain within the endoplasmic reticulum2,3. The determinant for both assembly and degradation is located in a segment of eight residues containing two basic amino acids (Fig. 1). We show here that placement of a single basic residue in the transmembrane domain of the Tac antigen can induce interaction with the CD3 chain, through its transmembrane acidic residue. This interaction is most favoured when the interacting residues are located at the same level in the membrane. The ability to induce protein–protein interaction by placing charge pairs within transmembrane domains suggests an approach to producing artificial dimers. More... »

PAGES

414-416

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/351414a0

DOI

http://dx.doi.org/10.1038/351414a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021237613

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1827877


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