Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-05

AUTHORS

S Sokol, D A Melton

ABSTRACT

Activin, a peptide growth factor related to tumour growth factor-beta, has been implicated in early inductive interactions in vertebrates and can induce Xenopus blastula ectodermal explants to develop a rudimentary axial pattern with anteroposterior and dorsoventral polarity. Here we demonstrate that prospective dorsal and ventral regions of the ectoderm respond differently to the same concentration of activin. Thus, activin does not seem to endow ectodermal cells with polarity but rather reveals a pre-existent pattern. Our results suggest that patterning of mesoderm is determined not only by a localized inducer, but also by the differential competence of cells in the responding tissue. More... »

PAGES

409-411

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/351409a0

DOI

http://dx.doi.org/10.1038/351409a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023809834

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2034291


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