Characterization of a murine gene expressed from the inactive X chromosome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-05

AUTHORS

G Borsani, R Tonlorenzi, M C Simmler, L Dandolo, D Arnaud, V Capra, M Grompe, A Pizzuti, D Muzny, C Lawrence, H F Willard, P Avner, A Ballabio

ABSTRACT

In mammals, equal dosage of gene products encoded by the X chromosome in male and female cells is achieved by X inactivation. Although X-chromosome inactivation represents the most extensive example known of long range cis gene regulation, the mechanism by which thousands of genes on only one of a pair of identical chromosomes are turned off is poorly understood. We have recently identified a human gene (XIST) exclusively expressed from the inactive X chromosome. Here we report the isolation and characterization of its murine homologue (Xist) which localizes to the mouse X inactivation centre region and is the first murine gene found to be expressed from the inactive X chromosome. Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation. More... »

PAGES

325-329

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/351325a0

DOI

http://dx.doi.org/10.1038/351325a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004451883

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2034278


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