Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-05

AUTHORS

T. J. Murphy, R. Wayne Alexander, Kathy K. Griendling, Marschall S. Runge, Kenneth E. Bernstein

ABSTRACT

ANGIOTENSIN II is an important effector molecule controlling blood pressure and volume in the cardiovascular system1. Its importance is manifested by the efficacy of angiotensin-converting enzyme inhibitors in the treatment of hypertension and congestive heart failure2,3. Angiotensin II interacts with two pharmacologi-cally distinct subtypes of cell-surface receptors, AT1 and AT2 (ref. 4). AT1 receptors seem to mediate the major cardiovascular effects of angiotensin II5,6. Here we report the isolation by expression cloning of a complementary DNA encoding a unique protein with the pharmacological specificity of a vascular AT1 receptor. Hydropathic modelling of the deduced protein suggests that it shares the seven-transmembrane-region motif with the G protein-coupled receptor superfamily7. Knowledge of the AT1 receptor primary sequence should now permit structural analysis, definition of the angiotensin II receptor gene family and delineation of the contribution of AT receptors to the genetic component of hypertension. More... »

PAGES

233-236

Journal

TITLE

Nature

ISSUE

6323

VOLUME

351

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/351233a0

DOI

http://dx.doi.org/10.1038/351233a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035923039

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2041570


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