Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1991-05

AUTHORS

Bernard Binétruy, Tod Smeal, Michael Karin

ABSTRACT

Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts. More... »

PAGES

122-127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/351122a0

DOI

http://dx.doi.org/10.1038/351122a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010881668

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1903181


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203 rdf:type schema:Organization
 




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