T-cell regulation by CD28 and CTLA-4 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

M L Alegre, K A Frauwirth, C B Thompson

ABSTRACT

Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one provided on engagement of co-stimulatory receptors, such as CD28. Recent studies are providing clues as to the specific signalling roles of co-stimulatory receptors. Furthermore, superimposition of inhibitory signals, such as those delivered by cytotoxic T-lymphocyte antigen 4 (CTLA-4), leads to a complex network of positive and negative co-stimulatory signals, the integration of which modulates immune responses. More... »

PAGES

220-228

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35105024

DOI

http://dx.doi.org/10.1038/35105024

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045984420

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11905831


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