Chk2 kinase — a busy messenger View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

J Bartek, J Falck, J Lukas

ABSTRACT

Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic evolution. Recent studies show the fundamental role of Chk2 in the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both hereditary and sporadic human cancers, and earmark this kinase as a candidate tumour suppressor and an attractive target for drug discovery. More... »

PAGES

877-886

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Molecular Cell Biology

    ISSUE

    12

    VOLUME

    2

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35103059

    DOI

    http://dx.doi.org/10.1038/35103059

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005636144

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11733767


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