Chk2 kinase — a busy messenger View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-12

AUTHORS

J Bartek, J Falck, J Lukas

ABSTRACT

Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic evolution. Recent studies show the fundamental role of Chk2 in the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both hereditary and sporadic human cancers, and earmark this kinase as a candidate tumour suppressor and an attractive target for drug discovery. More... »

PAGES

877-886

References to SciGraph publications

Journal

TITLE

Nature Reviews Molecular Cell Biology

ISSUE

12

VOLUME

2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35103059

DOI

http://dx.doi.org/10.1038/35103059

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005636144

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11733767


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