Gridlock signalling pathway fashions the first embryonic artery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

Tao P. Zhong, Sarah Childs, James P. Leu, Mark C. Fishman

ABSTRACT

Arteries and veins are morphologically, functionally and molecularly very different, but how this distinction is established during vasculogenesis is unknown1,2. Here we show, by lineage tracking in zebrafish embryos, that angioblast precursors for the trunk artery and vein are spatially mixed in the lateral posterior mesoderm. Progeny of each angioblast, however, are restricted to one of the vessels. This arterial–venous decision is guided by gridlock (grl), an artery-restricted gene that is expressed in the lateral posterior mesoderm3. Graded reduction of grl expression, by mutation or morpholino antisense, progressively ablates regions of the artery, and expands contiguous regions of the vein, preceded by an increase in expression of the venous marker EphB4 receptor (ephb4)2 and diminution of expression of the arterial marker ephrin-B2 (efnb2)2. grl is downstream of notch4, and interference with notch signalling, by blocking Su(H)4, similarly reduces the artery and increases the vein. Thus, a notch–grl pathway controls assembly of the first embryonic artery, apparently by adjudicating an arterial versus venous cell fate decision. More... »

PAGES

216-220

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35102599

DOI

http://dx.doi.org/10.1038/35102599

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009535704

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11700560


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