Stem cells, cancer, and cancer stem cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

T Reya, S J Morrison, M F Clarke, I L Weissman

ABSTRACT

Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells' - rare cells with indefinite potential for self-renewal that drive tumorigenesis. More... »

PAGES

105-111

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  • Journal

    TITLE

    Nature

    ISSUE

    6859

    VOLUME

    414

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/35102167

    DOI

    http://dx.doi.org/10.1038/35102167

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021100179

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11689955


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