Stem cells find their niche View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

A Spradling, D Drummond-Barbosa, T Kai

ABSTRACT

The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically. More... »

PAGES

98-104

Journal

TITLE

Nature

ISSUE

6859

VOLUME

414

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/35102160

DOI

http://dx.doi.org/10.1038/35102160

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021584545

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11689954


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